Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

Brand, Rhonda M.; Wipf, Peter; Durham, Austin; Epperly, Michael W.; Greenberger, Joel S.; Falo, Louis D.

doi:10.3389/fphar.2018.00920

Cited by 124Skin Protection and AgingMitochondrial Function and PathologyPhytochemicals and Antioxidant Activities

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

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Brand, Rhonda M., Wipf, Peter, Durham, Austin, Epperly, Michael W., Greenberger, Joel S., Falo, Louis D.·2018·Frontiers in Pharmacology

DOI 10.3389/fphar.2018.00920PMC PMC6110189

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Abstract

Unmitigated UV radiation (UVR) induces skin photoaging and multiple forms of cutaneous carcinoma by complex pathways that include those mediated by UV-induced reactive oxygen species (ROS). Upon UVR exposure, a cascade of events is induced that overwhelms the skin's natural antioxidant defenses and results in DNA damage, intracellular lipid and protein peroxidation, and the dysregulation of pathways that modulate inflammatory and apoptotic responses. To this end, natural products with potent antioxidant properties have been developed to prevent, mitigate, or reverse this damage with varying degrees of success. Mitochondria are particularly susceptible to ROS and subsequent DNA damage as they are a major intracellular source of oxidants. Therefore, the development of mitochondrially targeted agents to mitigate mitochondrial oxidative stress and resulting DNA damage is a logical approach to prevent and treat UV-induced skin damage. We summarize evidence that some existing natural products may reduce mitochondrial oxidative stress and support for synthetically generated mitochondrial targeted cyclic nitroxides as potential alternatives for the prevention and mitigation of UVR-induced skin damage.

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UVR is responsible for generating approximately 10-fold more mutations in mtDNA than in nuclear DNA.
“However, UVR is responsible for the generation of a higher amount (approximately 10-fold increase) of mutations in mtDNA than in nuclear DNA.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [140]

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Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies
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Authors: Brand, R. M., Wipf, P., Durham, A., Epperly, M. W., Greenberger, J. S., & Falo, L. D.
Affiliations: University of Pittsburgh (US)
Corresponding author: Falo, Louis D.
ORCID: Brand, Rhonda M.
Wipf, Peter
Epperly, Michael W.
Greenberger, Joel S.
Falo, Louis D.
Venue: Frontiers in Pharmacology
Publisher: Frontiers Media SA
Published: 2018-08-20
Volume: 9
Pages: 920-920
ISSN: 1663-9812 (ISSN-L)
DOI: 10.3389/fphar.2018.00920
PMC: PMC6110189
OpenAlex: W2888227984
Cited by: 124
References: 101
Citations by year: 2026: 15 · 2025: 24 · 2024: 20 · 2023: 18 · 2022: 15 · 2021: 14 · 2020: 13 · 2019: 5
FWCI: 1.29
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: Frontiers in Pharmacology (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: Wallace H. Coulter Foundation
National Institutes of Health (U19A168021)
National Institute of Allergy and Infectious Diseases (U19AI068021, RC1AI081284, U19A168021)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: mitochondrial oxidative stress, ultraviolet radiation, photoaging, reactive oxygen species, DNA damage, lipid peroxidation, protein peroxidation, natural antioxidants, skin cancer prevention, apoptosis, inflammation

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Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

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