Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms

Nichols, Joi A.; Katiyar, Santosh K.

doi:10.1007/s00403-009-1001-3

Cited by 1,103Skin Protection and AgingPhytochemicals and Antioxidant Activitiesmelanin and skin pigmentation

Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms

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Nichols, Joi A., Katiyar, Santosh K.·2010·Archives of Dermatological Research

DOI 10.1007/s00403-009-1001-3PMC PMC2813915

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Abstract

Epidemiological, clinical and laboratory studies have implicated solar ultraviolet (UV) radiation in various skin diseases including, premature aging of the skin and melanoma and non-melanoma skin cancers. Chronic UV radiation exposure-induced skin diseases or skin disorders are caused by the excessive induction of inflammation, oxidative stress and DNA damage, etc. The use of chemopreventive agents, such as plant polyphenols, to inhibit these events in UV-exposed skin is gaining attention. Chemoprevention refers to the use of agents that can inhibit, reverse or retard the process of these harmful events in the UV-exposed skin. A wide variety of polyphenols or phytochemicals, most of which are dietary supplements, have been reported to possess substantial skin photoprotective effects. This review article summarizes the photoprotective effects of some selected polyphenols, such as green tea polyphenols, grape seed proanthocyanidins, resveratrol, silymarin and genistein, on UV-induced skin inflammation, oxidative stress and DNA damage, etc., with a focus on mechanisms underlying the photoprotective effects of these polyphenols. The laboratory studies conducted in animal models suggest that these polyphenols have the ability to protect the skin from the adverse effects of UV radiation, including the risk of skin cancers. It is suggested that polyphenols may favorably supplement sunscreens protection, and may be useful for skin diseases associated with solar UV radiation-induced inflammation, oxidative stress and DNA damage.

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Epigallocatechin-3-gallate may effectively inhibit production of reactive oxygen species by infiltrating leukocytes upon UV-B exposure.
“As a result, it may effectively inhibit the production of reactive oxygen species by these infiltrating leukocytes upon UV-B exposure (Nichols and Katiyar 2010).”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Nichols and Katiyar 2010
Epigallocatechin-3-gallate has the ability to prevent UV-B-induced leukocyte infiltration in both mouse and human skin.
“Epigallocatechin-3-gallate has the ability to prevent UV-B-induced leukocyte infiltration in both mouse and human skin.”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Nichols and Katiyar 2010
Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects.
“Plant polyphenols are considered important substances for skin function, with hydrating, smoothing, softening, soothing and astringent effects [25,190,193,197,198,199].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [197]
Polyphenols soothe irritation and reduce the redness of skin, accelerate the natural regeneration of the epidermis, stabilize the capillaries, improve microcirculation and elasticity in the skin, and protect against harmful external factors, including UV radiation.
“Furthermore, they soothe irritation and reduce the redness of skin, accelerating the natural regeneration of the epidermis, stabilizing the capillaries, improving microcirculation and elasticity in the skin, and protecting against harmful external factors, including UV radiation [188,197,198,200].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [197]
Polyphenols inhibit the activity of enzymes present in the skin-collagenase and elastase, which catalyze the hydrolysis of collagen and elastin fibers, and hyaluronidase, which degrades hyaluronic acid.
“Polyphenols inhibit the activity of enzymes present in the skin—collagenase and elastase, which catalyze the hydrolysis of collagen and elastin fibers, and hyaluronidase, which degrades hyaluronic acid.”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [197]

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3 retracted

RETRACTED: Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin
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Retracted
Retraction: (–)-Epigallocatechin-3-Gallate Prevents Photocarcinogenesis in Mice through Interleukin-12–Dependent DNA Repair
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Authors: Nichols, J. A., & Katiyar, S. K.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Katiyar, Santosh K.
ORCID: Katiyar, Santosh K.
Venue: Archives of Dermatological Research
Publisher: Springer Science and Business Media LLC
Published: 2009-11-07
Volume: 302
Issue: 2
Pages: 71-83
ISSN: 0003-9187 (ISSN-L)
0340-3696
1432-069X
DOI: 10.1007/s00403-009-1001-3
PMC: PMC2813915
OpenAlex: W2165749758
Cited by: 1,103
References: 106
Citations by year: 2026: 53 · 2025: 71 · 2024: 65 · 2023: 78 · 2022: 72 · 2021: 75 · 2020: 72 · 2019: 68 · 2018: 70 · 2017: 82 · 2016: 53 · 2015: 85 · 2014: 64 · 2013: 75 · 2012: 57
FWCI: 6.00
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Archives of Dermatological Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health
National Cancer Institute (CA 104428, R21CA104428)
National Center for Complementary and Integrative Health (AT 002536, R01AT002536)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: skin photoprotection, natural polyphenols, ultraviolet radiation, oxidative stress, DNA damage, chemoprevention, green tea polyphenols, proanthocyanidins, resveratrol, silymarin, genistein, melanoma, non-melanoma skin cancer, skin aging, dietary supplements
MeSH terms: Anti-Inflammatory Agents, Antioxidants, Catechin, Dermatitis, DNA Damage, DNA Repair, Flavonoids, Humans, Neoplasms, Radiation-Induced, Phenols, Skin, Skin Neoplasms, Sunscreening Agents, Tea, Ultraviolet Rays, Polyphenols

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Skin photoprotection by natural polyphenols: Anti-inflammatory, antioxidant and DNA repair mechanisms

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