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Consumption of Two Healthy Dietary Patterns Restored Microbiota Dysbiosis in Obese Patients with Metabolic Dysfunction
Abstract
SCOPE: The consumption of two healthy diets (Mediterranean (MED) and low-fat (LF) diets) may restore the gut microbiome dysbiosis in obese patients depending on the degree of metabolic dysfunction. METHODS AND RESULTS: The differences in bacterial community at baseline and after 2 years of dietary intervention of 106 subjects from the CORDIOPREV study were analyzed, 33 of whom were obese patients with severe metabolic disease (5 criteria for metabolic syndrome) (MetS-OB), 32 obese patients without metabolic dysfunction (2 or less criteria for metabolic syndrome) (NonMetS-OB) and 41 non-obese subjects (NonMetS-NonOB). Our study showed a marked dysbiosis in people with severe metabolic disease (Met-OB), compared with obese people without MetS (NonMetS-OB) and non-obese people (NonMetS-NonOB). This disbiotic pattern was reversed by consumption of both MED (35% of calories as fat (22% MUFA fat, 6% PUFA fat and <10% saturated fat) or LF (<30% total fat (<10% saturated fat, 12%-14% MUFA fat and 6-8% PUFA fat) diets, whereas no significant microbiota changes were observed in NonMetS-NonOB and NonMetS-OB groups. CONCLUSION: Our results suggest that the chronic intake of two healthy dietary patterns partially restores the gut microbiome dysbiosis in obese patients with coronary heart disease, depending on the degree of metabolic dysfunction.
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“For example, after 2 years, consumption of a Mediterranean dietary pattern and a low-fat dietary pattern has been shown to partially restore loss of keystone taxa in 33 participants with obesity and varying levels of metabolic dysfunction [101].”
From Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019) · cites this paper as [101]
In the citing paper
“Consistently, in a recent randomized clinical trial, obese individuals randomized to a Mediterranean diet for 2 years experienced a reshaping of the gut microbiota, with an increase in Bacteroides, Prevotella, and Faecalibacterium genera, and most importantly of the Roseburia and Ruminococcus genera and Parabacteroides distasonis and Faecalibacterium prausnitzii bacterial species, which are known”
From Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms (2018) · cites this paper as [93]
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Metadata
- Authors
- Haro, C., García‐Carpintero, S., Rangel‐Zúñiga, O. A., Alcalá‐Díaz, J. F., Landa, B. B., Clemente, J. C., Pérez‐Martínez, P., López‐Miranda, J., Pérez‐Jiménez, F., & Camargo, A.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Icahn School of Medicine at Mount Sinai (US)
- Hospital Universitario Reina Sofía (ES)
- Corresponding author
- Camargo, Antonio
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2017-11-07
- Volume
- 61
- Issue
- 12
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2753997213
- Cited by
- 149
- References
- 46
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 21 · 2023: 13 · 2022: 25 · 2021: 20 · 2020: 12 · 2019: 24 · 2018: 4 · 2017: 1
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Ministerio de Economía y Competitividad (AGL2012/39615, PIE14/00005, PIE 14/00031, AGL2015/‐67896‐P, CP14/00114, FIS PI13/00023, FIS PI13/00185, PI13/00619, FIS PI16/01777)
- European Regional Development Fund
- Instituto de Salud Carlos III (CP14/00114, PI13/00185, PI13/00619, PIE 14/00031, PIE14/00005)
- Secretaría de Estado de Investigación, Desarrollo e Innovación (AGL2012/39615, AGL2015/‐67896‐P)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, dysbiosis, obesity, metabolic syndrome, Mediterranean diet, low-fat diet, dietary fat composition, monounsaturated fatty acids, polyunsaturated fatty acids, saturated fat, coronary artery disease, CORDIOPREV study, dietary intervention
- MeSH terms
- Gastrointestinal Microbiome, Feces, Humans, Male, Middle Aged, Obesity, Treatment Outcome, Diet, Fat-Restricted, Metabolic Syndrome, Diet, Mediterranean, Dysbiosis
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