CoChat
Sign Up
Cited by 121

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Dietary Intervention Modifies DNA Methylation Age Assessed by the Epigenetic Clock

Sae‐Lee, Chanachai, Corsi, Sarah, Barrow, Timothy M., Kuhnle, Gunter G. C., Bollati, Valentina, Mathers, John C., Byun, Hyang‐Min·2018·Molecular Nutrition & Food Research
DOI 10.1002/mnfr.201800092
Open this paper in CoChat — free account

Abstract

Scope: Alterations in DNA methylation patterns are correlated with aging, environmental exposures, and disease pathophysiology; the possibility of reverting or preventing these processes through dietary intervention is gaining momentum. In particular, methyl donors that provide S‐adenosyl‐methionine for one‐carbon metabolism and polyphenols such as flavanols that inhibit the activity of DNA methyltransferases (DNMTs) can be key modifiers of epigenetic patterns. Methods and results: DNA methylation patterns are assessed in publicly available Illumina Infinium 450K methylation datasets from intervention studies with either folic acid + vitamin B12 (GSE74548) or monomeric and oligomeric flavanols (MOF) (GSE54690) in 44 and 13 participants, respectively. Global DNA methylation levels are increased in unmethylated regions such as CpG islands and shores following folic acid + vitamin B12 supplementation and decreased in highly methylated regions, including shelves and open‐seas, following intervention with MOF. After supplementation with folic acid + vitamin B12, epigenetic age, estimated by the Horvath “epigenetic clock” model, is reduced in women with the MTHFR 677CC genotype. Conclusions: The effects of supplementation with folic acid + vitamin B12 and MOF on DNA methylation age are dependent upon gender and MTHFR genotype. Additionally, the findings demonstrate the potential for these dietary factors to modulate global DNA methylation profiles.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/mnfr.201800092

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 34

  1. 10.1038/ncponc0354 · DOI
  2. Luczak M. W., 2006, Folia Histochem. Cytobiol., 44, 143
  3. 10.1186/s13148-016-0300-8 · DOI
  4. 10.1161/CIRCRESAHA.115.305206 · DOI
  5. 10.1515/med-2017-0014 · DOI
  6. 10.1038/nrg1655 · DOI · Paper page
  7. 10.1093/qjmed/hcg039 · DOI
  8. Fodinger M., 2000, J. Nephrol, 13, 20
  9. 10.1002/ajmg.10704 · DOI
  10. 10.1073/pnas.062066299 · DOI
  11. 10.1371/journal.pone.0182472 · DOI
  12. 10.1016/B978-0-12-380864-6.00001-8 · DOI
  13. 10.1007/s00109-015-1268-0 · DOI
  14. 10.1207/S15327914NC3701_13 · DOI
  15. Fang M. Z., 2003, Cancer Res., 63, 7563
  16. 10.1016/j.mad.2006.01.018 · DOI
  17. 10.1073/pnas.1412759111 · DOI
  18. 10.1186/s13148-015-0154-5 · DOI
  19. 10.1371/journal.pone.0095527 · DOI
  20. 10.1182/blood-2012-09-459313 · DOI
  21. 10.1093/bioinformatics/btu049 · DOI
  22. 10.1093/hmg/ddp445 · DOI
  23. 10.1016/j.ejmg.2014.10.004 · DOI · Paper page
  24. 10.1093/jn/133.11.3416 · DOI
  25. 10.1371/journal.pone.0024976 · DOI
  26. 10.1186/s13059-016-1030-0 · DOI
  27. 10.1093/ije/dyw041 · DOI
  28. 10.1093/jn/138.8.1456 · DOI
  29. 10.1016/j.molcel.2012.10.016 · DOI · Paper page
  30. 10.1093/hmg/ddt375 · DOI
  31. 10.1186/s13059-015-0584-6 · DOI · Paper page
  32. 10.1038/s41467-017-00607-3 · DOI · Paper page
  33. 10.1289/EHP595 · DOI
  34. 10.3945/ajcn.116.145680 · DOI

Cited by

Sorted by citations

Metadata

Authors
Sae‐Lee, C., Corsi, S., Barrow, T. M., Kuhnle, G. G. C., Bollati, V., Mathers, J. C., & Byun, H.
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2018-11-02
Volume
62
Issue
23
ISSN
  • 1613-4125
  • 1613-4133
DOI
10.1002/mnfr.201800092
Cited by
121
References
7
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review