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Caloric restriction delays age-related methylation drift

Maegawa, Shinji, Lu, Yue, Tahara, Tomomitsu, Lee, Justin T., Madzo, Jozef, Liang, Shoudan, Jelinek, Jaroslav, Colman, Ricki J., Issa, Jean-Pierre J.·2017·Nature Communications
DOI 10.1038/s41467-017-00607-3PMC PMC5599616
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Abstract

In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. Here, we report that epigenetic drift is conserved across species and the rate of drift correlates with lifespan when comparing mice, rhesus monkeys, and humans. Twenty-two to 30-year-old rhesus monkeys exposed to 30% caloric restriction since 7–14 years of age showed attenuation of age-related methylation drift compared to ad libitum-fed controls such that their blood methylation age appeared 7 years younger than their chronologic age. Even more pronounced effects were seen in 2.7–3.2-year-old mice exposed to 40% caloric restriction starting at 0.3 years of age. The effects of caloric restriction on DNA methylation were detectable across different tissues and correlated with gene expression. We propose that epigenetic drift is a determinant of lifespan in mammals.

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Metadata

Authors
Maegawa, S., Lu, Y., Tahara, T., Lee, J. T., Madzo, J., Liang, S., Jelinek, J., Colman, R. J., & Issa, J.-P. J.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2017-09-14
Volume
8
Issue
1
ISSN
2041-1723
DOI
10.1038/s41467-017-00607-3
PMC
PMC5599616
Cited by
270
References
13
Language
en
Licence

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