Cited by 178Epigenetics and DNA MethylationBirth, Development, and HealthNutrition, Genetics, and Disease

DNA methylation in metabolic disorders

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Barres, Romain, Zierath, Juleen R·2011·The American Journal of Clinical Nutrition

Abstract

DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders.

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Crossref · 10.3945/ajcn.110.001933

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  • Recent developments in epigenetics may provide the basis for a better understanding of the pathophysiological mechanisms underlying the Metabolic Syndrome.

    “Recent developments in epigenetics may also provide the basis for a better understanding of the pathophysiological mechanisms underlying what to date we have called the Metabolic Syndrome 4, 47.”

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Authors
Barres, R., & Zierath, J. R.
Affiliations
UNSW Sydney (AU)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2011-04
Volume
93
Issue
4
Pages
897S-900S
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2137923929
Cited by
174
References
42
Citations by year
2026: 11 · 2025: 4 · 2024: 9 · 2023: 11 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 19 · 2014: 9 · 2013: 13 · 2012: 14
FWCI
5.57
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords
DNA methylation, epigenetics, metabolic disorders, diabetes mellitus, obesity, gene expression, environmental factors, diet, physical activity, genetic susceptibility
MeSH terms
Diet, Environment, Humans, Metabolic Diseases, Exercise, Gene Expression, DNA Methylation, Genetic Predisposition to Disease, Epigenesis, Genetic

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