Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota

Oxidative stress, aging, and diseases

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Gut microbiota composition correlates with diet and health in the elderly

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The gut microbiome in health and in disease

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Object recognition test in mice

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Gut microbiota and aging

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Cellular senescence drives age-dependent hepatic steatosis

Ogrodnik, M., Miwa, S., Tchkonia, T., Tiniakos, D., Wilson, C. L., Lahat, A., Day, C. P., Burt, A., Palmer, A., Anstee, Q. M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15691 · Cited by 1,044

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

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Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

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Lactobacillus plantarum QL01 Alleviates D-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Ageing Mice

Li, H., Zhang, M., Wu, D., Gong, D., Huang, J., Tang, Z., Wang, L., & Zhang, Y. (2025) · Nutrients · doi:10.3390/nu18010035 · Cited by 4

Improvement of Lactiplantibacillus plantarum MWFLp-182 on oxidative deficits induced by in 2,2’-azobis(2-methylpropionamidine) dihydrochloride and the relating key gene analysis

Nie, H., Ma, X., Kong, F., Luo, Y., Mu, G., & Wu, X. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250026 · Cited by 5

N-Acetyl Transferase, Shati/Nat8l, in the Dorsal Hippocampus Suppresses Aging-induced Impairment of Cognitive Function in Mice

Miyanishi, H., Kitazawa, A., Izuo, N., Muramatsu, S., & Nitta, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03594-0 · Cited by 3

Post-Weaning Treatment with Probiotic Inhibited Stress-Induced Amnesia in Adulthood Rats: The Mediation of GABAergic System and BDNF/c-Fos Signaling Pathways

Alizadeh, K., Moghimi, H., Golbabaei, A., Alijanpour, S., & Rezayof, A. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03625-w · Cited by 4

Can Antidiabetic Medications Affect Telomere Length in Patients with Type 2 Diabetes? A Mini-Review

Qin, B. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s428560 · Cited by 5

Gut microbiota dysbiosis and protein energy wasting in patients on hemodialysis: an observational longitudinal study

Bi, X., Liu, Y., Lu, Y., Ling, L., Lü, J., Hu, C., & Ding, W. Q. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1270690 · Cited by 4

The role of probiotics on slowing down the aging process

Şanlibaba, P., Toprak, Z. T., & Tezel, B. U. (2022) · Acta Scientiarum Polonorum Technologia Alimentaria · doi:10.17306/j.afs.1013 · Cited by 4

Gut Microbial Genetic Variation Prolongs Host Healthy Longevity and Remodels Metabolome and Proteome in Drosophila Melanogaster

Wang, L., Yang, Z., Pang, Y., Wu, X., Zhang, X., Zhu, T., Ding, X., Liu, W., Zhou, Y., Zhang, P., et al. (2025) · Advanced Science · doi:10.1002/advs.202505469 · Cited by 3

Resistant starch-driven remodeling of gut microbiota and metabolite profiles enhanced by sodium butyrate supplementation

Zhang, G., Zhang, Y., Zheng, B., Zeng, H., & Zheng, Y. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108855 · Cited by 3

The role of gut microbiota on skeletal muscle strength in LDLR knockdown aging mice

Li, Y., Fang, Z., Luo, Y., Liu, H., Zhao, D., Feng, T., Zhang, X., Mo, S., Fang, X., Huang, L., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-00059-6 · Cited by 3

Lactobacilli Probiotics Prevent Amyloid-Beta Fibril Formation In Vitro

Harrass, S., Quansah, M., Kumar, S., Radzieta, M., Jayawardena, B. M., Jones, C. E., David, M. A., Heng, B., Elbourne, L. D. H., Amanquah, S. D., et al. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10776-z · Cited by 3

Influence of Antimicrobials on the Gut Microbiota

Chowdhury, G., & Ramamurthy, T. (2020) · Springer eBooks · doi:10.1007/978-981-15-3658-8_3 · Cited by 3

Melatonin reduced colon inflammation but had no effect on energy metabolism in ageing Mongolian gerbils (Meriones unguiculatus)

Gao, W., Liu, J.-X., Wang, D., Sun, H., & Zhang, X. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109731 · Cited by 3

Role of microbiota-gut-brain axis in neurodegenerative diseases and the potential of microbiome-targeted dietary strategies: a review of current evidence and future perspective

Zhang, S., Chen, W., Ma, C., Luo, Y., Dong, L., Hu, X., Chen, F., & Li, D. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250215 · Cited by 2

Probiotics as a targeted intervention in anti-ageing: a review

Shi, F., Peng, J., Li, H., Liu, D., Han, L., Wang, Y., Liu, Q., & Liu, Q. (2024) · Biomarkers · doi:10.1080/1354750x.2024.2424388 · Cited by 2

Correlation between gut microbiota and musculoskeletal diseases

Alessandro de, S. I. R. E., Marotta, N., Zito, R., Invernizzi, M., & Ammendolia, A. (2024) · International Journal of Bone Fragility · doi:10.57582/ijbf.240402.054 · Cited by 3

Alteration of the intestinal microbiota associated with the development of nonalcoholic steatohepatitis and sarcopenia in SHRSP5/Dmcr

Fukuoka, T., Yamamoto, S., Honma, K., Fujii, M., Nakayama, H., Kirihara, S., Gotoh, K., Tsuji, S., Kawai, Y., Tago, H., et al. (2025) · Folia Microbiologica · doi:10.1007/s12223-025-01283-3 · Cited by 2

Photobiomodulation Strengthens Muscles via Its Dual Functions in Gut Microbiota

Upadhyay, P., Banstola, A., Bhayana, B., & Wu, M. X. (2025) · Advanced Science · doi:10.1002/advs.202511582 · Cited by 2

Probiotics: Emerging functional ingredients for healthy aging and age-related diseases

Tan, P. L., & Kim, S. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818588-9.00002-4 · Cited by 2

Understanding Alzheimer’s Disease by Targeting Gut Microbiota and Role of Heavy Metals: Insight from Novel Therapeutical Approach

Bhratee, A., Kumar, M., Alam, M. R., Anand, P., & Singh, S. (2023) · Current Pharmacology Reports · doi:10.1007/s40495-023-00325-z · Cited by 2

Contribution of the Microbiota to Healthy Aging

Forssten, S. D., & Ouwehand, A. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00059-0 · Cited by 2

Synergistical amelioration of muscle atrophy by modulating gut microbiota through the bioconversion of grape seed extract and whey using kefir lactic acid bacteria

Seo, K., Kim, E., & Kim, H. (2025) · Future Foods · doi:10.1016/j.fufo.2025.100559 · Cited by 1

Lacticaseibacillus paracasei LPB27 ameliorates depressive-like behaviors in CUMS rats by inhibiting IDO-1 and regulating tryptophan metabolism

Huang, L., Xiao, J., Jie, L., Wei, X., Zheng, Y., Zhao, X., Ma, Z., Xue, J., Yu, X., Ze, X., et al. (2025) · Food Science and Human Wellness · doi:10.26599/fshw.2025.9250477 · Cited by 1

Lactobacillus Reuteri L81 Alleviates Intestinal Barrier Damage Induced by Escherichia Coli K99 in Mice by Modulating Gut Microbiota Composition and Metabolic Products

Li, J., Peng, H., Liang, W., Chen, L., Li, Y., & Zhang, W. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10831-9 · Cited by 1

Association between gut microbiota dysbiosis and perioperative neurocognitive disorder and postoperative complications after valve replacement surgery: a prospective cohort study

Deng, Q.-Y., Tang, M., Gao, J., & Liang, P. (2025) · BMC Anesthesiology · doi:10.1186/s12871-025-03521-0 · Cited by 2

Dystrophic Skeletal Muscle Phenotypes Can Be Horizontally Transferred via Fecal Microbiome Transplantations

Butcher, J., Gosse, J. T., Gobin, J., Ravel‐Chapuis, A., Jasmin, B. J., & Stintzi, A. (2025) · The FASEB Journal · doi:10.1096/fj.202502999r · Cited by 2

Silent Intruders: The Gut Virome in Brain Aging and Cognitive Decline

Silvestro, S., Midiri, A., Biondo, C., Casilli, S., Borrello, L., Zummo, S., & Mancuso, G. (2026) · Pathogens · doi:10.3390/pathogens15020180 · Cited by 2

Integrative perspective on the maternal gut-brain-breast axis: Linking dietary polyphenols, mental health, and human milk composition

Miranda, A. R., Barral, P. E., Serra, S. V., & Soria, E. A. (2026) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2026.110334 · Cited by 1

Gut microbiota transplantation from young adult mice fails to restore low bone and muscle mass in old mice

Lawenius, L., Hägg, D. A., Horkeby, K., Nilsson, K. H., Wu, J., Grahnemo, L., Ohlsson, C., & Sjögren, K. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00522.2025 · Cited by 1

Gut Microbiota Signatures of Sarcopenia: A Comparative 16S rRNA Sequencing Study in Older Indian Adults

George, S. M., Chatterjee, P., Chaudhry, R., Bamola, V. D., Khan, M. A., Purohit, A., Suroliya, V., Muley, R., & Chakrawarty, A. (2026) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.70500 · Cited by 1

Role of gut microbiota modulation in preventing and treating sarcopenia in patients with liver cirrhosis: A narrative review

Yang, M., Liu, T., Yang, Q., Cai, R., Yang, X., & Tang, C. (2026) · Arab Journal of Gastroenterology · doi:10.1016/j.ajg.2026.03.005 · Cited by 1

Association between gut microbiota and sarcopenia in older adults: a cross-sectional analysis from the second wave of the Birjand Longitudinal Aging Study (BLAS)

Kashal, F. R., Sharifi, F., Najafi, S., Marvasti, F. E., Moodi, M., Shafaei, E., Taghavi, M., Hosseini, F.-S., Khorashadizadeh, M., Namaei, M. H., et al. (2026) · Aging Clinical and Experimental Research · doi:10.1007/s40520-026-03403-6 · Cited by 1

Gut Microbiota as a Mediator of Sarcopenic Obesity: Mechanisms, Modifiable Factors, and Healthcare Burden

Söğüt, M. Ü., AHISKALI, M., Mohammadzadeh, M., Çelik, M. N., & Us, N. C. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70495 · Cited by 1

Links between bone fractures and the gut microbiota

Ohlsson, C., Lawenius, L., Grahnemo, L., & Sjögren, K. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-026-01286-1 · Cited by 2

The gut microbiota in cachexia: master regulator of neuro-immune-metabolic cross-talk

Gao, K., Xi, W., Lei, Y., Ni, J., Zhang, C., Feng, W., Ouyang, Y., An, Y., Li, X., Wu, B., et al. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101502 · Cited by 1

Perspective Chapter: The Role of Modifiable Factors, Particularly Nutritional Factors, on Age-Related Sarcopenia

Mashhadi, N. S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.105433 · Cited by 1

Interplay Between Gut-microbiota and Neurodegeneration

Ashique, S., Pal, R., Kumar, S., Verma, B., Kumar, N., Kahwa, I., Farid, A., Mishra, N., Kumar, P., & Taghizadeh‐Hesary, F. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815238754124010009 · Cited by 1

Microbial-Derived Exerkines Prevent Skeletal Muscle AtrophyPreprint

Valentino, T. R., Burke, B. I., Kang, G., Goh, J. Z., Dungan, C. M., Ismaeel, A., Mobley, C. B., Flythe, M. D. D., Wen, Y., & McCarthy, J. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.596432 · Cited by 1

The role of probiotics on slowing down the aging process [pdf]

Şanlıbaba, P., Toprak, Z. T., & TEZEL, B. U. (2022) · Acta Scientiarum Polonorum Technologia Alimentaria · doi:10.17306/j.afs.2022.1013

Corrigendum: Lacticaseibacillus casei CNCM I-5663 supplementation maintained muscle mass in a model of frail rodents

Giron, M., Thomas, M., Jarzaguet, M., Mayeur, C., Ferrere, G., Noordine, M.-L., Bornes, S., Dardevet, D. P., Chassard, C., & Savary‐Auzeloux, I. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1109835 · Cited by 1

Additional file 4 of The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

Jin, Z., Yang, Y., Cao, Y., Wen, Q., Yu, X., Cheng, J., Zhao, Q., Weng, J., Hong, K., Jiang, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24202587

Additional file 2 of The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

Jin, Z., Yang, Y., Cao, Y., Wen, Q., Yu, X., Cheng, J., Zhao, Q., Weng, J., Hong, K., Jiang, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24202581

Additional file 3 of The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

Jin, Z., Yang, Y., Cao, Y., Wen, Q., Yu, X., Cheng, J., Zhao, Q., Weng, J., Hong, K., Jiang, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24202584

Lactobacilli Probiotics Prevent Amyloid-Beta Fibril Formation In VitroPreprint

Harrass, S., Quansah, M., Kumar, S., Radzieta, M., Jayawardena, B. M., Jones, C. E., David, M. A., Heng, B., Elbourne, L. D. H., Amanquah, S. D., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6505627/v1

Bushen Yinao pill improves cognitive function in Alzheimer's disease rats by regulating PI3K/Akt pathway and intestinal microbiota

Lan, S., Gao, F., Ji, R., Wang, Z., Zang, Z., Wei, Y., Kuang, H., & Wang, Z. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106999

The Potential Mediating Role of Depressive Symptoms in the Inverse Association Between Dietary Index of Gut Microbiota and Overactive Bladder: A Cross‐Sectional Study

Zhang, Y., Wang, X., Li, J., Huang, R., Zhang, P., Tan, Z., Wan, Y., & Hu, H. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70349

Influence of healthy gut microbiota against neurodegeneration and aging

Kumari, R., Rai, A. K., Singh, K. B., & Hati, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33355-2.00016-5

Lactobacillus helveticus-derived whey alleviates scopolamine-induced cognitive impairment in mice via the gut-brain axis

Sun, Y., Gao, S., Yang, J., Liu, Z., Xia, A.-N., Lee, Y.-K., Yang, B., Liu, X.-M., Zhou, P., Zhao, J.-X., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.108073

Lactobacillus delbrueckii subsp. lactis CKDB001 Ameliorates Scopolamine-Induced Cognitive Impairment Through Metabolic Modulation

Kim, H., Kim, H., Lee, Y., Park, C.-H., Cho, B., Son, S. Y., Kim, H.-Y., Kim, G., Park, J., & Park, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411804

Du besoin de revisiter l’ostéosarcopénie par l’apport du microbiote intestinal

Cailleaux, P. (2025) · Revue du Rhumatisme · doi:10.1016/j.rhum.2025.11.004

Additional file 1 of The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

Jin, Z., Yang, Y., Cao, Y., Wen, Q., Xi, Y., Cheng, J., Zhao, Q., Weng, J., Hong, K., Jiang, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24202578

Effect of Probiotic Supplementation on Muscle Strength After Myocardial Revascularization: A Randomized, Controlled, Triple-Blind Clinical Trial

Gimenes, I. M., Silvestre, E. G., Cabral, L. Q. T., Cantero, M. A., Gomes, R. L., da Silva, A. K. F., Trindade, E. B. S. D. M., & Fernandes, R. (2026) · Nutraceuticals · doi:10.3390/nutraceuticals6010012

Research progress on the role of gut microbiota in skeletal muscle atrophy

Wen-Ya, G. U. O., XIANG, S.-J., ZHANG, X.-L., Yao, L., & Li, Y. (2026) · Shengming kexue · doi:10.3724/cbls.2026011

Diets, phytochemicals, drugs, and nutraceuticals for reverse aging

Kamila, P., Dutta, R., Kuilya, M., Neogi, S., Kar, K., Chakraborty, P., Chowdhury, S., Chandrasekaran, K., & Singh, S. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33159-6.00002-3

Gut Microbiota and Skeletal Muscle Interaction: The Role of Short-Chain Fatty Acids, G-Protein Receptor Signaling and Metabolic Adaptation

Kalkan, H. (2026) · Physiology · doi:10.5772/intechopen.1015465 · Cited by 1

Intestinal Lactobacillus: Origins, colonization factors, diversity, and health associations

Liu, J., Luo, M., Li, B., Xia, X., & Huang, L. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108681

Lactiplantibacillus plantarum WY2401 promotes myogenesis via riboflavin-mediated modulation of METTL3-dependent mRNA m6A methylation

Liu, J., Yang, T., Lou, F., Chen, W., Xin, Z., Chen, S., Ren, R., & Wang, X. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.08.015

The Gut Microbiota–Muscle Axis: Lactobacillus as a Potential Modulator of Skeletal Muscle Health

Janet, B., Jena, R., Rao, B. S. S., & Dehury, B. (2026) · BioMed Research International · doi:10.1155/bmri/7133290

Centenarian-Sourced Lactobacillus casei Combined with Dietary Fiber Complex Ameliorates Brain and Gut Function in Aged Mice

Ren, M., Li, H., Fu, Z., & Li, Q. (2022) · Nutrients · doi:10.3390/nu14020324 · Cited by 35

Bifidobacterium bifidum and Lactobacillus paracasei alleviate sarcopenia and cognitive impairment in aged mice by regulating gut microbiota-mediated AKT, NF-κB, and FOXO3a signaling pathways

Baek, J.-S., Shin, Y.-J., Ma, X., Park, H.-S., Hwang, Y.-H., & Kim, D. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00381-5 · Cited by 59

Probiotics Ameliorate Aging-Related Cognitive Impairments and Pathological Changes through Alleviating Telomere Attrition and Enhancing Mitochondrial Function in Senescence-Accelerated Mouse Prone 8 Mice

Zhou, S., Shan, S., Li, R., Wang, X., Xiong, J., & Cheng, G. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c09572 · Cited by 6

Antiaging Effects of Human Fecal Transplants with Different Combinations of Bifidobacterium bifidum LTBB21J1 and Lactobacillus casei LTL1361 in d -Galactose-Induced Mice

Zhou, F., Zhang, Q., Zheng, X., Shi, F., Ma, K., Ji, F., Meng, N., Li, R., Lv, J., & Li, Q. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c09815 · Cited by 13

Lactobacillus plantarum LLY-606 Supplementation Ameliorates the Cognitive Impairment of Natural Aging in Mice: The Potential Role of Gut Microbiota Homeostasis

Shi, R., Jin, Y., Fan, H., Hu, X., Wu, X., Wang, D., Zhao, B., Dai, X., & Liu, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07041 · Cited by 20