The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence suggesting that L‐fucose is part of a recognition signal for sperm‐zona pellucida attachment in mammals
Abstract
Experiments were designed to test the effects of simple sugars and complex polysaccharides on the attachment of mammalian spermatozoa with the zona pellucida. In the guinea pig, L‐fucose was a twofold better inhibitor of the attachment compared to other sugars at 50 mM. Fucoidin, an algal polysaccharide rich in sulfated L‐fucose, was a very potent inhibitor, completely blocking attachment at a concentration of 100 μg/ml. Several other highly sulfated glycosaminoglycans showed no inhibitory activity, suggesting the fucoidin effect was not simply due to its charge or sulfate. In addition, fragments of fucoidin, generated by partial hydrolysis and isolated using Biogel P‐2, were nearly as inhibitory as the native molecule on a weight basis. Fucoidin also inhibited sperm‐zona attachment in the hamster and human; thus, its effect is not species specific. The data suggest that L‐fucose may be part of a recognition signal between mammalian gametes.
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Cites
Carbohydrates of the brown seaweeds himanthalia lorea and bifurcaria bifurcata
Mian, A. J., & Percival, E. (1973) · Carbohydrate Research · doi:10.1016/s0008-6215(00)85031-4 · Cited by 50
Cited by
O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity
Florman, H. M., & Wassarman, P. M. (1985) · Cell · doi:10.1016/0092-8674(85)90084-4 · Cited by 584
A revised structure for fucoidan may explain some of its biological activities.
Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80609-7 · Cited by 531
The Biology and Chemistry of Fertilization
Wassarman, P. M. (1987) · Science · doi:10.1126/science.3027891 · Cited by 391
Profile of a mammalian sperm receptor1,2
Wassarman, P. M. (1990) · Development · doi:10.1242/dev.108.1.1 · Cited by 362
Human Sperm Binding Is Mediated by the Sialyl-Lewis x Oligosaccharide on the Zona Pellucida
Pang, P.-C., Chiu, P. C. N., Lee, C.-L., Chang, L.-Y., Panico, M., Morris, H. R., Haslam, S. M., Khoo, K.-H., Clark, G. F., Yeung, W. S. B., et al. (2011) · Science · doi:10.1126/science.1207438 · Cited by 338
Metadata
- Authors
- Huang, T. T. F., Ohzu, E., & Yanagimachi, R.
- Venue
- Gamete Research
- Publisher
- Wiley
- Published
- 1982-01
- Volume
- 5
- Issue
- 4
- Pages
- 355-361
- ISSN
- 0148-7280 (ISSN-L)
- 1554-3919
- OpenAlex
- W1979334990
- Cited by
- 165
- References
- 1
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, T. T. F., Ohzu, E., & Yanagimachi, R. (1982). Evidence suggesting that L‐fucose is part of a recognition signal for sperm‐zona pellucida attachment in mammals. Gamete Research. https://doi.org/10.1002/mrd.1120050406
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
