A revised structure for fucoidan may explain some of its biological activities.
Open accessAbstract
Fucoidan from Fucus vesiculosus inhibits human sperm-zona pellucida binding and blocks the zona pellucida-induced acrosome reaction in human sperm. Fucoidan also potently inhibits selectin-mediated adhesion of leukocytes to vascular endothelium. To understand the molecular basis for fucoidan's inhibition of specific cell adhesion events, we have investigated the structure of this fucan using definitive methods of carbohydrate structural analysis. We report the revised average structure for fucoidan. [formula: see text] This average structure differs from the previous model for fucoidan in two respects. First, the core region of the fucan is composed primarily of a polymer of alpha 1-3-linked fucose with sulfate groups substituted at the 4 position on some of the fucose residues. Secondly, fucose is also attached to this polymer to form branch points, one for every 2-3 fucose residues within the chain. This revised average structure is consistent with previous studies suggesting a branched random coil as the best model for this polysaccharide. The proposed model is also a closer structural analogue of the sulfated carbohydrate ligands that bind to selectins. This information should be useful for determining whether a relationship exists between selectin-mediated adhesion of leukocytes and human sperm-egg binding.
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Fucoidan from Fucus vesiculosus has a backbone primarily composed of α-(1-3) linkages, with fucose at branched points attached via α-(1-2) or α-(1-4) linkages, and significant sulfate substitution at positions 3 and 4.
“The backbone structure of FCSP from Fucus vesiculosus was presented by Patankar et al. (1993) [17], who proposed that the polymer is primarily composed of α-(1-3) linkages where fucose at branched points is attached via α-(1-2) or α-(1-4) linkages. A significant amount of sulfate substitution was observed at positions 3 and 4, and the fucose core chain was substituted with C-4 sulfates.”
From A Review on Fucoidan Structure, Extraction Techniques, and Its Role as an Immunomodulatory Agent (2022) · cites this paper as [17]
Fucose is attached to the backbone fucan polymer of F. vesiculosus to form branching points, typically one for every 2-3 fucose residues within the chain, with sulfate groups at position C-4 on the fucose units.
“it was also reported that fucose was attached to the backbone fucan polymer to form branching points, typically one for every 2–3 fucose residues within the chain, still with sulfate groups at position C-4 on the fucose units [31].”
In 1993 a revised structure of the polysaccharide backbone of the main FCSP product from F. vesiculosus was presented as α(1→3) linked instead of as α(1→2) linked.
“In 1993 a revised structure of the polysaccharide backbone of the main FCSP product from F. vesiculosus was presented as α(1→3) linked instead of as α(1→2) linked [31]”
The initial suggestion that fucoidan obtained from F. vesiculosus was built of α(1→2)-linked L-fucopyranosyl has been revised.
“Therefore the initial suggestion that fucoidan obtained from F. vesiculosus (Fucales) was built of a(1A2) linked L-fucopyranosyl has been revised.16”
From Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation (2013) · cites this paper as [16]
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- Authors
- Patankar, M. S., Oehninger, S., Barnett, T., Williams, R. L., & Clark, G. F.
- Affiliations
- Eastern Virginia Medical School (US)
- Venue
- Journal of Biological Chemistry
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- Elsevier BV
- Published
- 1993-10
- Volume
- 268
- Issue
- 29
- Pages
- 21770-21776
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1509009405
- Cited by
- 531
- References
- 46
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- FWCI
- 13.81
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- journal article
- Language
- en
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- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- fucoidan, Fucus vesiculosus, polysaccharide structure, fucose, sulfated polysaccharides, leukocyte-endothelial adhesion, sperm-zona pellucida binding, acrosome reaction, polysaccharide structure elucidation
- MeSH terms
- Carbohydrate Conformation, Carbohydrate Sequence, Carbohydrates, Chromatography, Ion Exchange, Chromatography, Thin Layer, Methylation, Molecular Sequence Data, Polysaccharides, Spectrophotometry, Infrared
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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