Cited by 18Reproductive Biology and FertilityGestational Diabetes Research and ManagementBirth, Development, and Health

The effect of peri-conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence

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Frank, Laura A., Sutton‐McDowall, Melanie L., Gilchrist, Robert B., Thompson, Jeremy G.·2014·Molecular Reproduction and Development

Abstract

SUMMARY: The environment that the oocyte is exposed to during the peri‐conception period can have a significant impact on oocyte developmental competence (the ability of the oocyte to support fertilisation and subsequent embryo development) and the long‐term health of the resulting offspring. This is particularly true for maternal hyperglycaemia. While maternal hyperglycaemia during early pregnancy through term development has been extensively studied, the effects on the oocyte itself, and the underlying mechanisms, remain largely unknown. There is increasing evidence, however, for the role of the fuel‐sensing hexosamine biosynthesis pathway in mediating the effects of hyperglycaemia in many different cell types. In this review, we will focus on the reproductive consequences of maternal hyperglycaemia during the peri‐conceptual period and the role of the hexosamine pathway in mediating these processes. Mol. Reprod. Dev. 81: ???–???, 2014. © 2014 Wiley Periodicals, Inc.

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Authors
Frank, L. A., Sutton‐McDowall, M. L., Gilchrist, R. B., & Thompson, J. G.
Affiliations
The University of Adelaide (AU)
Corresponding author
Thompson, Jeremy G.
Venue
Molecular Reproduction and Development
Publisher
Wiley
Published
2014-01-27
Volume
81
Issue
5
Pages
391-408
ISSN
  • 1040-452X (ISSN-L)
  • 1098-2795
OpenAlex
W1953108540
Cited by
18
References
221
Citations by year
2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
FWCI
0.26
Type
journal article
Language
en
Open access
Locations
  • Molecular Reproduction and Development (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
maternal hyperglycemia, hexosamine biosynthetic pathway, oocyte developmental competence, embryo developmental competence, oocyte quality, embryo quality, offspring health
MeSH terms
Animals, Embryo, Mammalian, Female, Hexosamines, Humans, Hyperglycemia, Oocytes, Pregnancy, Embryonic Development

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