The effect of peri-conception hyperglycaemia and the involvement of the hexosamine biosynthesis pathway in mediating oocyte and embryo developmental competence
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SUMMARY: The environment that the oocyte is exposed to during the peri‐conception period can have a significant impact on oocyte developmental competence (the ability of the oocyte to support fertilisation and subsequent embryo development) and the long‐term health of the resulting offspring. This is particularly true for maternal hyperglycaemia. While maternal hyperglycaemia during early pregnancy through term development has been extensively studied, the effects on the oocyte itself, and the underlying mechanisms, remain largely unknown. There is increasing evidence, however, for the role of the fuel‐sensing hexosamine biosynthesis pathway in mediating the effects of hyperglycaemia in many different cell types. In this review, we will focus on the reproductive consequences of maternal hyperglycaemia during the peri‐conceptual period and the role of the hexosamine pathway in mediating these processes. Mol. Reprod. Dev. 81: ???–???, 2014. © 2014 Wiley Periodicals, Inc.
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Men with type 1 diabetes have fewer offspring.
“and a reduced number of offspring (T1D). 1545–1548”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1545]
The Introduction and §2.1 discuss maternal diabetes and reproductive outcomes in women, not the number of offspring fathered by men with type 1 diabetes. Searches for men with type 1 diabetes, paternal diabetes, and reduced offspring found no passage addressing the claim. (LLM, conf=0.76)
Experimental — accuracy not yet measuredMen with type 1 or type 2 diabetes have higher infertility rates.
“Men with DM (T1D or T2D) have higher rates of infertility”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1545]
The Introduction discusses maternal type 1 and type 2 diabetes, and §2.1 discusses poor conception and pregnancy complications in women with diabetes. Searches for male infertility, paternal diabetes, and sperm found no passage addressing infertility rates in men with either type of diabetes; page numbers were unavailable in our copy. (LLM, conf=0.76)
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The status of diabetic embryopathy
Eriksson, U. J., & Wentzel, P. (2016) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2016.1165317 · Cited by 46 · see citing works
Brown, H. M., Green, E. S., Tan, T. C. Y., Gonzalez, M. B., Rumbold, A. R., Hull, M. L., Norman, R. J., Packer, N. H., Robertson, S. A., & Thompson, J. G. (2018) · Scientific Reports · doi:10.1038/s41598-018-19263-8 · Cited by 42 · see citing works
Self-citationImpact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy
Kim, G., Cao, L., Reece, E. A., & Zhao, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-11655-6 · Cited by 36 · see citing works
Disruption of O‐GlcNAc homeostasis during mammalian oocyte meiotic maturation impacts fertilization
Zhou, L. T., Romar, R., Pavone, M. E., Soriano‐Úbeda, C., Zhang, J., Slawson, C. M., & Duncan, F. E. (2019) · Molecular Reproduction and Development · doi:10.1002/mrd.23131 · Cited by 27 · see citing works
Hyperglycaemia and lipid differentially impair mouse oocyte developmental competence
Wong, S. L., Wu, L., Robker, R. L., Thompson, J. G., & McDowall, M. (2015) · Reproduction Fertility and Development · doi:10.1071/rd14328 · Cited by 19 · see citing works
Self-citationFeng, C., Yuan, T., Wang, S., Liu, T., Tao, S., Han, D., & Wang, J. (2020) · BioMed Research International · doi:10.1155/2020/1630890 · Cited by 9 · see citing works
RetractedGlucose concentration during equine in vitro maturation alters mitochondrial function
Lewis, N., Hinrichs, K., Leese, H. J., Argo, C. M., Brison, D. R., & Sturmey, R. G. (2020) · Reproduction · doi:10.1530/rep-20-0032 · Cited by 9 · see citing works
Influence of hyperproteinemia on reproductive development in an invertebrate model
Wang, Y., Chen, X., Wang, G., Li, Q., Liang, X., Sima, Y., & Xu, S. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.33310 · Cited by 7 · see citing works
Embryo metabolism : what does it really mean?
Lewis, N., & Sturmey, R. G. (2015) · Repository@Hull (Worktribe) (University of Hull) · Cited by 7 · see citing works
Metabolic control of oocyte development
Zhu, S., & Wang, Q. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioac082 · Cited by 6 · see citing works
Advantages of Screening for Glucose Tolerance in the Sequential Weeks of Gestation
Seshiah, V., Balaji, V., Chandrasekar, A., Das, A. K., Banerjee, S., Paneerselvam, A., Jain, R. K., & Bhavatharani, N. (2021) · Journal of Social Health and Diabetes · doi:10.1055/s-0041-1736086
Metabolic control of oocyte development
YiQiu, W. U., Shuai, Z. H. U., & Qiang, W. A. N. G. (2023) · Scientia Sinica Vitae · doi:10.1360/ssv-2023-0152
- Authors
- Frank, L. A., Sutton‐McDowall, M. L., Gilchrist, R. B., & Thompson, J. G.
- Affiliations
- The University of Adelaide (AU)
- Corresponding author
- Thompson, Jeremy G.
- Venue
- Molecular Reproduction and Development
- Publisher
- Wiley
- Published
- 2014-01-27
- Volume
- 81
- Issue
- 5
- Pages
- 391-408
- ISSN
- 1040-452X (ISSN-L)
- 1098-2795
- OpenAlex
- W1953108540
- Cited by
- 18
- References
- 221
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Reproduction and Development (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- maternal hyperglycemia, hexosamine biosynthetic pathway, oocyte developmental competence, embryo developmental competence, oocyte quality, embryo quality, offspring health
- MeSH terms
- Animals, Embryo, Mammalian, Female, Hexosamines, Humans, Hyperglycemia, Oocytes, Pregnancy, Embryonic Development
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