Current Knowledge of Obesity’s Effects in the Pre-and Periconceptional Periods and Avenues for Future Research
Open accessAbstract
The prevalence of obesity is growing among reproductive-age women. This is concerning because obesity has significant health-related consequences. Aside from the long-term risks of diabetes, heart disease, and some types of cancer, obesity poses immediate threats for young women including subfertility and adverse early and late pregnancy outcomes. Epidemiologic and experimental studies demonstrate associations between prepregnancy obesity and poor reproductive outcomes; however, the mechanisms involved are poorly understood. We discuss current knowledge of the pathophysiology of obesity in early reproductive events and how these events may affect reproductive outcomes including fertility and miscarriage risk. We also discuss avenues for future research and interventions to improve reproductive outcomes for obese women.
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Adipocytes are responsible for the functional alteration of the hypothalamic-pituitary-ovarian (HPO) axis due to aromatization of androgens to estrogens, which by negative feedback loop suppress gonadotropin production.
“Furthermore, adipocytes are responsible for the functional alteration of the hypothalamic-pituitary-ovarian (HPO) axis due to aromatization of androgens to estrogens, which by negative feedback loop, suppress gonadotropin production [84,86].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [86]
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Self-citationObesity and reproductive function
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- Authors
- Jungheim, E. S., & Moley, K. H.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 203
- Issue
- 6
- Pages
- 525-530
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC3718032
- OpenAlex
- W1976745100
- Cited by
- 190
- References
- 90
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 16 · 2023: 8 · 2022: 13 · 2021: 20 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 17 · 2014: 14 · 2013: 13 · 2012: 13
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (K12HD063086-01)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- obesity, pre-pregnancy obesity, periconceptional period, female fertility, subfertility, miscarriage risk, adverse pregnancy outcomes, women of reproductive age, obesity pathophysiology
- MeSH terms
- Female, Fertility, Forecasting, Humans, Health Knowledge, Attitudes, Practice, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Research, Severity of Illness Index, Body Mass Index, Preconception Care, Risk Assessment, Reproductive Techniques, Assisted, Fetal Development
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