The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Intrauterine infection and prematurity
Abstract
Intrauterine infection is a major cause of premature labor with and without intact membranes. Intrauterine infection is present in approximately 25% of all preterm births and the earlier the gestational age at delivery, the higher the frequency of intra‐amniotic infection. Microorganisms may also gain access to the fetus before delivery. A fetal inflammatory response syndrome elicited in response to microbial products is associated with the impending onset of preterm labor and also with multi‐systemic organ involvement in the human fetus and a higher rate of perinatal morbidity. The most common microorganisms involved in intrauterine infections are Ureaplasma urealyticum, Fusobacterium species and Mycoplasma hominis. The role of Chlamydia trachomatis and viruses in preterm labor remain to be determined. Use of molecular microbiology techniques to diagnose intrauterine infection may uncover the role of fastidious microorganisms that have not yet been discovered. Antibiotic administration to patients with asymptomatic bacteriuria is associated with a significant reduction in the rate of preterm birth. However, such benefit has not been demonstrated for patients with bacterial vaginosis, or women who carry Streptococcus agalactia, Ureaplasma urealyticum or Trichomonas vaginalis. Antibiotic administration to patients with preterm premature rupture of membranes is associated with prolongation of pregnancy and a reduction in the rate of clinical chorioamnionitis and neonatal sepsis. The benefit has not been demonstrated in patients with preterm labor and intact membranes. Major efforts are required to determine why some women develop an ascending intrauterine infection and others do not and also what interventions may reduce the deleterious effect of systemic fetal inflammation. MRDD Research Reviews 2002;8:3–13. © 2002 Wiley‐Liss, Inc.
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Cites
Intrauterine infection and preterm delivery
Goldenberg, R. L., Hauth, J. C., & Andrews, W. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422007 · Cited by 2,548
The fetal inflammatory response syndrome
Gomez, R., Romero, R., Ghezzi, F., Yoon, B. H., Mazor, M., & Berry, S. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70272-8 · Cited by 1,111
Self-citationThe Agent of Bacillary Angiomatosis: An Approach to the Identification of Uncultured Pathogens
Relman, D. A., Loutit, J. S., Schmidt, T. M., Falkow, S., & Tompkins, L. S. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012063232301 · Cited by 901
Trichomonas vaginalis Associated With Low Birth Weight and Preterm Delivery
COTCH, M. F., PASTOREK, J. G., NUGENT, R. P., HILLIER, S. L., GIBBS, R. S., MARTIN, D. H., ESCHENBACH, D. A., EDELMAN, R., CAREY, C. J., REGAN, J. A., et al. (1997) · Sexually Transmitted Diseases · doi:10.1097/00007435-199707000-00008 · Cited by 836
Romero, R., Sirtori, M., Oyarzun, E., Avila, C., Mazor, M., Callahan, R., Sabo, V., Athanassiadis, A. P., & Hobbins, J. C. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90409-2 · Cited by 678
Self-citationThe preterm prediction study: significance of vaginal infections
Meis, P. J., Goldenberg, R. L., Mercer, B., Moawad, A., Das, A., McNellis, D., Johnson, F., Iams, J. D., Thom, E., & Andrews, W. W. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91360-2 · Cited by 410
Adverse outcome in pregnancy following amniotic fluid isolation of Ureaplasma urealyticum
Gray, D. J., Robinson, H. B., Malone, J., & Thomson, R. B. (1992) · Prenatal Diagnosis · doi:10.1002/pd.1970120206 · Cited by 187
Intrauterine viral infection at the time of second trimester genetic amniocentesis
Wenstrom, K. (1998) · Obstetrics & Gynecology · doi:10.1016/s0029-7844(98)00210-5 · Cited by 110
(1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(12)91102-3 · Cited by 31
Cited by
The preterm parturition syndrome
Romero, R., Espinoza, J., Kusanovic, J., Gotsch, F., Hassan, S., Erez, O., Chaiworapongsa, T., & Mazor, M. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01120.x · Cited by 1,419
Self-citationRomero, R., Hassan, S. S., Gajer, P., Tarca, A. L., Fadrosh, D. W., Nikita, L., Galuppi, M., Lamont, R. F., Chaemsaithong, P., Miranda, J., et al. (2014) · Microbiome · doi:10.1186/2049-2618-2-4 · Cited by 852
Self-citationClinical Outcomes of Near-Term Infants
Wang, M. L., Dorer, D. J., Fleming, M. P., & Catlin, E. A. (2004) · Pediatrics · doi:10.1542/peds.114.2.372 · Cited by 771
Inflammation in preterm and term labour and delivery
Romero, R., Espinoza, J., Gonçalves, L. F., Kusanovic, J. P., Friel, L. A., & Nien, J. K. (2006) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2006.05.001 · Cited by 746
Self-citationClinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants
Kaufman, D., & Fairchild, K. D. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.3.638-680.2004 · Cited by 435
Metadata
- Authors
- Gonçalves, L. F., Chaiworapongsa, T., & Romero, R.
- Venue
- Mental Retardation and Developmental Disabilities Research Reviews
- Publisher
- Wiley
- Published
- 2002-01
- Volume
- 8
- Issue
- 1
- Pages
- 3-13
- ISSN
- 1080-4013 (ISSN-L)
- 1098-2779
- OpenAlex
- W2137416873
- Cited by
- 596
- References
- 9
- FWCI
- 15.69
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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