The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
MR molecular imaging of the Her‐2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles
Open accessAbstract
MR molecular imaging is an exciting new frontier in the biomedical applications of MR. One of the clinically relevant targets is the tyrosine kinase Her‐2/neu receptor, which has a significant role in staging and treating breast cancer. In this study Her‐2/neu receptors were imaged in a panel of breast cancer cells expressing different numbers of the receptors on the cell membrane. Commercially available streptavidin‐conjugated superparamagnetic nanoparticles were used as targeted MR contrast agent. The nanoparticles were directed to receptors prelabeled with a biotinylated monoclonal antibody and generated strong T2 MR contrast in Her‐2/neu‐expressing cells. The contrast observed in MR images was proportional to the expression level of Her‐2/neu receptors determined independently with FACS analysis. In these experiments, iron oxide nanoparticles were attached to the cell surface and were not internalized into the cells, which is a major advantage for in vivo applications of the method. Magn Reson Med 49:403–408, 2003. © 2003 Wiley‐Liss, Inc.
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Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer
Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Levin, W. J., Stuart, S. G., Udove, J., Ullrich, A., et al. (1989) · Science · doi:10.1126/science.2470152 · Cited by 6,816
Shapiro, H. M. (2003) · Wiley eBooks · doi:10.1002/0471722731 · Cited by 2,671
Weissleder, R., & Mahmood, U. (2001) · Radiology · doi:10.1148/radiology.219.2.r01ma19316 · Cited by 1,315
Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging
Sipkins, D. A., Cheresh, D. A., Kazemi, M. R., Nevin, L. M., Bednarski, M. D., & Li, K. C. P. (1998) · Nature Medicine · doi:10.1038/nm0598-623 · Cited by 850
Bulte, J. W. M., Zhang, S.-C., van Gelderen, P., Herynek, V., Jordan, E. K., Duncan, I. D., & Frank, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15256 · Cited by 531
Bioluminescent indicators in living mammals
Contag, P. R., Olomu, I. N., Stevenson, D. K., & Contag, C. H. (1998) · Nature Medicine · doi:10.1038/nm0298-245 · Cited by 517
Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases
Yang, M., Baranov, E., Jiang, P., Sun, F.-X., Li, X.-M., Li, L., Hasegawa, S., Bouvet, M., Al-Tuwaijri, M., Chishima, T., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1206 · Cited by 514
OSTEOGENESIS IMPERFECTA IS LINKED TO BOTH TYPE I COLLAGEN STRUCTURAL GENES
Sykes, B., Wordsworth, P., Ogilvie, D., Anderson, J., & Jones, N. (1986) · The Lancet · doi:10.1016/s0140-6736(86)91609-0 · Cited by 444
Venter, D., Kumar, S., Tuzi, N., & Gullick, W. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92736-x · Cited by 404
Investigations of avidin and biotin for imaging applications.
Hnatowich, D. J., Virzi, F., & Rusckowski, M. (1987) · PubMed · Cited by 398
Cited by
Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852
Reddy, L. H., Arias, J. L., Nicolas, J., & Couvreur, P. (2012) · Chemical Reviews · doi:10.1021/cr300068p · Cited by 2,010
Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging
Lee, J.-H., Huh, Y.-M., Jun, Y.-W., Seo, J.-W., Jang, J.-T., Song, H.-T., Kim, S., Cho, E.-J., Yoon, H.-G., Suh, J.-S., et al. (2007) · Nature Medicine · doi:10.1038/nm1467 · Cited by 1,897
Yang, J., Lee, C., Ko, H., Suh, J., Yoon, H., Lee, K., Huh, Y., & Haam, S. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703554 · Cited by 331
Biodegradable, polymeric nanoparticle delivery systems for cancer therapy
Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2007) · Nanomedicine · doi:10.2217/17435889.2.5.669 · Cited by 249
Metadata
- Authors
- Artemov, D., Mori, N., Okollie, B., & Bhujwalla, Z. M.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2003-03
- Volume
- 49
- Issue
- 3
- Pages
- 403-408
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2038037578
- Cited by
- 351
- References
- 25
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Artemov, D., Mori, N., Okollie, B., & Bhujwalla, Z. M. (2003). MR molecular imaging of the Her‐2/neu receptor in breast cancer cells using targeted iron oxide nanoparticles. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.10406
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