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Is multicomponent T2 a good measure of myelin content in peripheral nerve?
Open accessAbstract
Multicomponent T2 relaxation of normal and injured rat sciatic nerve was measured. The T2 relaxation was multiexponential, indicating the multicompartmental nature of T2 decay in nerve tissue. The size of the short, observed T2 component correlated very well with quantitative assessment of myelin using computer‐assisted histopathological image analysis of myelin. Specifically, the size of the short T2 component reflected the processes of myelin loss and remyelination accompanying Wallerian degeneration and regeneration following trauma. However, it represented all myelin present in the sample and did not distinguish between intact myelin and myelin debris. Other changes in T2 spectra were also observed and could be correlated with axonal loss and inflammation. The study also questions the validity of previously offered interpretations of T2 spectra of nerve. Magn Reson Med 49:638–645, 2003. © 2003 Wiley‐Liss, Inc.
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Cited by
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Self-citationMapping Infant Brain Myelination with Magnetic Resonance Imaging
Deoni, S. C. L., Mercure, E., Blasi, A., Gasston, D., Thomson, A., Johnson, M., Williams, S. C. R., & Murphy, D. G. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2106-10.2011 · Cited by 497
Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology
Laule, C., Leung, E., Li, D. K., Traboulsee, A. L., Paty, D. W., MacKay, A. L., & Moore, G. R. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506070928 · Cited by 489
Gleaning multicomponent T1 and T2 information from steady‐state imaging data
Deoni, S. C. L., Rutt, B. K., Arun, T., Pierpaoli, C., & Jones, D. K. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21704 · Cited by 472
Deoni, S. C. L., Dean, D. C., O'Muircheartaigh, J., Dirks, H., & Jerskey, B. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.037 · Cited by 390
Metadata
- Authors
- Webb, S., Munro, C. A., Midha, R., & Stanisz, G. J.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2003-03-18
- Volume
- 49
- Issue
- 4
- Pages
- 638-645
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2050722132
- Cited by
- 172
- References
- 0
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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