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Amide proton transfer (APT) contrast for imaging of brain tumors
Abstract
In this work we demonstrate that specific MR image contrast can be produced in the water signal that reflects endogenous cellular protein and peptide content in intracranial rat 9L gliosarcomas. Although the concentration of these mobile proteins and peptides is only in the millimolar range, a detection sensitivity of several percent on the water signal (molar concentration) was achieved. This was accomplished with detection sensitivity enhancement by selective radiofrequency (RF) labeling of the amide protons, and by utilizing the effective transfer of this label to water via hydrogen exchange. Brain tumors were also assessed by conventional T1‐weighted, T2‐weighted, and diffusion‐weighted imaging. Whereas these commonly‐used approaches yielded heterogeneous images, the new amide proton transfer (APT) technique showed a single well‐defined region of hyperintensity that was assigned to brain tumor tissue. Magn Reson Med 50:1120–1126, 2003. © 2003 Wiley‐Liss, Inc.
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Cited by
Chemical exchange saturation transfer (CEST): what is in a name and what isn't?
van Zijl, P. C. M., & Yadav, N. N. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22761 · Cited by 1,155
Self-citationZhou, J., Tryggestad, E., Wen, Z., Lal, B., Zhou, T., Grossman, R., Wang, S., Yan, K., Fu, D.-X., Ford, E., et al. (2011) · Nature Medicine · doi:10.1038/nm.2268 · Cited by 526
Self-citationChemical exchange saturation transfer imaging and spectroscopy
Zhou, J., & Zijl, P. C. M. V. (2006) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2006.01.001 · Cited by 485
Self-citationIn vivo imaging of glucose uptake and metabolism in tumors
Walker-Samuel, S., Ramasawmy, R., Torrealdea, F., Rega, M., Rajkumar, V., Johnson, S. P., Richardson, S., Gonçalves, M., Parkes, H. G., Årstad, E., et al. (2013) · Nature Medicine · doi:10.1038/nm.3252 · Cited by 479
van Zijl, P. C. M., Lam, W. W., Xu, J., Knutsson, L., & Stanisz, G. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.04.045 · Cited by 339
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Metadata
- Authors
- Zhou, J., Lal, B., Wilson, D. A., Laterra, J., & van Zijl, P. C. M.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2003-11-21
- Volume
- 50
- Issue
- 6
- Pages
- 1120-1126
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2003126239
- Cited by
- 660
- References
- 0
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhou, J., Lal, B., Wilson, D. A., Laterra, J., & van Zijl, P. C. M. (2003). Amide proton transfer (APT) contrast for imaging of brain tumors. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.10651
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