In vivo 1 H NMR spectroscopy of the human brain at 7 T
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In vivo 1H NMR spectra from the human brain were measured at 7 T. Ultrashort echo-time STEAM was used to minimize J-modulation and signal attenuation caused by the shorter T2 of metabolites. Precise adjustment of higher-order shims, which was achieved with FASTMAP, was crucial to benefit from this high magnetic field. Sensitivity improvements were evident from single-shot spectra and from the direct detection of glucose at 5.23 ppm in 8-ml volumes. The linewidth of the creatine methyl resonance was at best 9 Hz. In spite of the increased linewidth of singlet resonances at 7 T, the ability to resolve overlapping multiplets of J-coupled spin systems, such as glutamine and glutamate, was substantially increased. Characteristic spectral patterns of metabolites, e.g., myo-inositol and taurine, were discernible in the in vivo spectra, which facilitated an unambiguous signal assignment.
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Changes in glutamatergic levels may not be detectable with 1H-MRS.
“Also, changes in glutamatergic levels may not be detectable with 1 H-MRS.”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [59]
Glutamate and glutamine are difficult to distinguish at lower magnetic field strengths, which makes the quantification of glutamate and glutamine problematic.
“Glutamate and glutamine are difficult to distinguish at lower magnetic field strengths, which makes the quantification of glutamate and glutamine problematic.59”
From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [59]
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- Authors
- Tkáč, I., Andersen, P., Adriany, G., Merkle, H., Uǧurbil, K., & Gruetter, R.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Tkáč, Ivan
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2001-08-31
- Volume
- 46
- Issue
- 3
- Pages
- 451-456
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2004807720
- Cited by
- 394
- References
- 36
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 18 · 2023: 19 · 2022: 9 · 2021: 15 · 2020: 18 · 2019: 15 · 2018: 14 · 2017: 24 · 2016: 19 · 2015: 6 · 2014: 21 · 2013: 13 · 2012: 19
- FWCI
- 10.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health (P41RR08079)
- W.M. Keck Foundation
- National Foundation for Functional Brain Imaging
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- human brain, FastMap, glucose detection, glutamine, glutamate, myo-inositol, taurine, spectral linewidth, signal assignment
- MeSH terms
- Adult, Brain, Brain Mapping, Energy Metabolism, Humans, Image Enhancement, Magnetic Resonance Spectroscopy, Reference Values, Neurotransmitter Agents
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