Cited by 177Dementia and Cognitive Impairment ResearchAdvanced MRI Techniques and ApplicationsAlzheimer's disease research and treatments

Reduced hippocampal glutamate in Alzheimer disease

Rupsingh, R., Borrie, M., Smith, M., Wells, J.L., Bartha, R.·2011·Neurobiology of Aging

Abstract

Altered neurometabolic profiles have been detected in Alzheimer disease (AD) using (1)H magnetic resonance spectroscopy (MRS), but no definitive biomarker of mild cognitive impairment (MCI) or AD has been established. This study used MRS to compare hippocampal metabolite levels between normal elderly controls (NEC) and subjects with MCI and AD. Short echo-time (TE=46 ms) (1)H spectra were acquired at 4T from the right hippocampus of 23 subjects with AD, 12 subjects with MCI and 15 NEC. Absolute metabolite levels and metabolite ratios were compared between groups using a multivariate analysis of covariance (covariates: age, sex) followed by post hoc Tukey's test (p<0.05 significant). Subjects with AD had decreased glutamate (Glu) as well as decreased Glu/creatine (Cr), Glu/myo-inositol (mI), Glu/N-acetylaspartate (NAA), and NAA/Cr ratios compared to NEC. Subjects with AD also had decreased Glu/mI ratio compared to MCI. There were no differences between subjects with MCI and NEC. Therefore, in addition to NAA/Cr, decreased hippocampal Glu may be an indicator of AD.

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Crossref · 10.1016/j.neurobiolaging.2009.05.002

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  • Concentrations of Glu are lower in the posterior cingulate cortex of AD patients, either when measured alone or as a combined measure of Glu+glutamine (Glx).

    “Concentrations of Glu were also shown to be lower in the posterior cingulate cortex of AD patients, either when measured alone or as a combined measure of Glu+glutamine (Glx) (Antuono et al. 2001; Fayed et al. 2011; Rupsingh et al. 2011).”

    From Alzheimer’s disease: Targeting the glutamatergic system (2020) · cites this paper as Rupsingh et al. 2011

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Authors
Rupsingh, R., Borrie, M., Smith, M., Wells, J. L., & Bartha, R.
Affiliations
  • Western University (CA)
  • Lawson Health Research Institute (CA)
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2011-05
Volume
32
Issue
5
Pages
802-810
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2096219863
Cited by
177
References
52
Citations by year
2026: 11 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 4 · 2020: 8 · 2019: 8 · 2018: 10 · 2017: 13 · 2016: 12 · 2015: 8 · 2014: 17 · 2013: 18 · 2012: 12
FWCI
4.52
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Alzheimer's disease, mild cognitive impairment, hippocampus, glutamate, hippocampal metabolites, N-acetylaspartate, myo-inositol, creatine, metabolite ratios, biomarkers, neurometabolism
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Choline, Creatine, Female, Hippocampus, Humans, Inositol, Male, Magnetic Resonance Spectroscopy, Biomarkers, Glutamic Acid

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