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Cited by 709

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Localized high‐resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo

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Frahm, J., Bruhn, H., Gyngell, M. L., Merboldt, K. D., Hänicke, W., Sauter, R.·1989·Magnetic Resonance in Medicine

Abstract

Water‐suppressed localized proton NMR spectroscopy using stimulated echoes has been successfully applied to detect metabolites in the human brain in vivo. The STEAM spectroscopy sequence allows single‐step localization by exciting three intersecting slices. Water suppression is achieved by preceding chemical‐shift‐selective (CHESS) rf pulses. High‐resolution (0.05 ppm) proton NMR spectra of healthy volunteers have been obtained on a conventional 1.5‐T whole‐body MRI system (Siemens Magnetom). Volumes‐of‐interest (VOI) of 64 ml(4 × 4 × 4 cm 3) were localized in the occipital area of the brain and spectra were recorded within measuring times ranging from I s (single scan) to about 10 min. The experimental procedure is described in detail. Resonance assignments include acetate, N‐acetyl aspartate, γ‐amino butyrate, glutamine, glutamate, aspartate, creatine and phosphocreatine, choline‐containing compounds, taurine, and inositols. Cerebral lactate was found to be at a maximum concentration of 0.5 m M when assuming N‐acetyl aspartate in white matter to be 6 m M. © 1989 Academic Press, Inc.

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Metadata

Authors
Frahm, J., Bruhn, H., Gyngell, M. L., Merboldt, K. D., Hänicke, W., & Sauter, R.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
1989-01
Volume
9
Issue
1
Pages
79-93
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W2104150998
Cited by
709
References
23
FWCI
44.94
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Localized high‐resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo. https://app.cochat.ai/papers/10.1002/mrm.1910090110
The paper
Frahm, J., Bruhn, H., Gyngell, M. L., Merboldt, K. D., Hänicke, W., & Sauter, R. (1989). Localized high‐resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910090110

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