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Cited by 523

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Experimental determination of the BOLD field strength dependence in vessels and tissue

Gati, Joseph S., Menon, Ravi S., Uǧurbil, Kǎmil, Rutt, Brian K.·1997·Magnetic Resonance in Medicine

Abstract

High resolution functional MRI (fMRI) experiments were performed in human visual cortex at 0.5, 1.5, and 4 T to determine the blood oxygenation level dependent (BOLD) field strength response within regions of obvious venous vessels and cortical gray matter (“tissue”). T2*‐weighted FLASH images were collected in single‐ and multi‐echo mode and used to determine the intrinsic BOLD parameters, namely, signal‐to‐noise ratio (Ψ), the apparent transverse relaxation rate (R 2*) and the change in R 2* (ΔR 2*) between the activated and baseline states. The authors find the average percentage signal change (ΔS/S, measured at TE = T2*) to be large in vessels (13.3 ± 2.3%, 18.4 ± 4.0%, and 15.1 ± 1.2%) compared with that in tissue (1.4 ± 0.7%, 1.9 ± 0.7%, and 3.3 ± 0.2%) at 0.5, 1.5, and 4 T, respectively. The signal‐to‐noise ratio in optimized, fully relaxed proton density weighted gradient echo images was found to increase linearly with respect to the static magnetic field strength (B 0). The predicted upper bound on BOLD contrast‐to‐noise ratio (ΔS/R)max as a function of field strength was calculated and found to behave less than linearly in voxels containing vessels larger than the voxel itself and greater than linearly in voxels containing a mixture of capillaries and veins/venules with a diameter less than that of the voxel.

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Metadata

Authors
Gati, J. S., Menon, R. S., Uǧurbil, K., & Rutt, B. K.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
1997-08
Volume
38
Issue
2
Pages
296-302
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W2028575667
Cited by
523
References
5
FWCI
20.41
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Experimental determination of the BOLD field strength dependence in vessels and tissue. https://app.cochat.ai/papers/10.1002/mrm.1910380220
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Gati, J. S., Menon, R. S., Uǧurbil, K., & Rutt, B. K. (1997). Experimental determination of the BOLD field strength dependence in vessels and tissue. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910380220

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