Hepatic lipid accumulation in healthy subjects: A comparative study using spectral fat‐selective MRI and volume‐localized 1H‐MR spectroscopy
Abstract
Fat-selective MRI was applied to assess the amount and spatial distribution of hepatic lipids (HL) in healthy subjects. The results were compared with those obtained by localized 1H-MR spectroscopy (MRS). Ninety subjects (23-63 years old) underwent single-slice fat-selective MRI with spatial-spectral excitation and volume-localized spectroscopy at 1.5 T. HLs were analyzed in ventral and dorsal regions of interest (ROIs) of the liver in fat-selective images. Spectra were evaluated using the integral signal of methylene and methyl signals. The fat-selective images showed smooth and homogeneous distribution of HL over the entire cross section of the liver. There was, however, a marked interindividual variability in the amount of HL. MRS revealed a lipid signal fraction between 0.5% and 39.3%. The fat content in the ROIs in images correlated well with the spectroscopic results (r >or= 0.95). Both techniques provide sufficient sensitivity for a reliable and quantitative assessment of liver steatosis in subjects without liver disease. 1H-MRS has a higher sensitivity compared to MRI, especially for small amounts of HL, which may be of interest for metabolic interventions. Fat-selective images provide more spatial information about fat distribution, which makes this technique suitable for clinical imaging of patients with liver disease.
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Localised 1H-magnetic resonance spectroscopy can also be used to assess hepatic lipid content and is even more sensitive than imaging, especially for accurate quantification of low-lipid content.
“Localised 1 H-magnetic resonance spectroscopy (MRS) can also be used to assess hepatic lipid content and is even more sensitive than imaging, especially for accurate quanti fi cation of low-lipid content.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [165]
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Self-citation
- Authors
- Machann, J., Thamer, C., Schnoedt, B., Stefan, N., Haring, H., Claussen, C. D., Fritsche, A., & Schick, F.
- Affiliations
- University of Tübingen (DE)
- Corresponding author
- Machann, Jürgen
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2006-02-27
- Volume
- 55
- Issue
- 4
- Pages
- 913-917
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2123908001
- Cited by
- 162
- References
- 20
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 9 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 13 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 6 · 2013: 20 · 2012: 9
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Keywords
- hepatic lipid accumulation, hepatic steatosis, 1H magnetic resonance spectroscopy, healthy volunteers, interindividual variability
- MeSH terms
- Adult, Fatty Liver, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Magnetic Resonance Spectroscopy, Reproducibility of Results, Body Mass Index, Linear Models
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