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Cited by 274

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Localized short‐echo‐time proton MR spectroscopy with full signal‐intensity acquisition

Open access
Mlynárik, Vladimír, Gambarota, Giulio, Frenkel, Hanne, Gruetter, Rolf·2006·Magnetic Resonance in Medicine

Abstract

We developed a short‐echo‐time (TE) sequence for proton localized spectroscopy by combining a 1D add‐subtract scheme with a doubly slice‐selective spin‐echo (SE) sequence. The sequence preserves the full magnetization available from the selected volume of interest (VOI). By reducing the number of radiofrequency (RF) pulses acting on transverse magnetization, we were able to minimize the TE to the level that is achievable with the stimulated echo acquisition mode (STEAM) technique, and also gained a twofold increase in sensitivity. The use of an adiabatic pulse in the add‐subtract localization improved the efficiency of excitation in spatially inhomogeneous RF fields, which are frequently encountered at high magnetic fields. The localization performance and sensitivity gains of this method, which is termed SPin ECho, full Intensity Acquired Localized (SPECIAL) spectroscopy, were demonstrated in vivo in rat brains. In conjunction with spectroscopic imaging, a 2‐μl spatial resolution was accomplished with a signal‐to‐noise ratio (SNR) above 30, which is usually sufficient for reliable quantification of a large number of metabolites (neurochemical profile). Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.

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Metadata

Authors
Mlynárik, V., Gambarota, G., Frenkel, H., & Gruetter, R.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2006-09-21
Volume
56
Issue
5
Pages
965-970
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W1969772297
Cited by
274
References
13
FWCI
6.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Localized short‐echo‐time proton MR spectroscopy with full signal‐intensity acquisition. https://app.cochat.ai/papers/10.1002/mrm.21043
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Mlynárik, V., Gambarota, G., Frenkel, H., & Gruetter, R. (2006). Localized short‐echo‐time proton MR spectroscopy with full signal‐intensity acquisition. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.21043

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