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Cited by 86Advanced MRI Techniques and ApplicationsAdvanced NMR Techniques and ApplicationsAtomic and Subatomic Physics Research

Performance of a 200‐MHz cryogenic RF probe designed for MRI and MRS of the murine brain

Ratering, David, Baltes, Christof, Nordmeyer‐Massner, Jurek, Marek, Daniel, Rudin, Markus·2008·Magnetic Resonance in Medicine
DOI 10.1002/mrm.21629
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Abstract

A cryogenic 200‐MHz RF transmit/receive probe (CryoProbe) made of copper and designed for murine brain studies is described. The probe operates at 30K and its performance was compared to a home‐made surface coil of equal dimensions and a mouse head volume resonator, both operating at room temperature (RT). Since for small volumes of tissue interrogated (<5 mL) sample noise and thermal noise of the receiver are of comparable magnitude, considerable noise reduction can be achieved by cooling of the receiver system, e.g., using cold helium gas. The effect of temperature lowering on the signal‐to‐noise ratio (SNR) was assessed in phantom and in vivo murine brain studies using conventional MRI sequences (spin and gradient echo) and single voxel MR spectroscopy. Consistent sensitivity increases were observed for the CryoProbe. SNR increases by a factor ≥2 for the phantom experiments and by factors of 1.8 to 1.9 for in vivo experiments when compared to the RT surface coil for both MRI and MRS experiments. These results are in good agreement with estimated SNR gains for a circular surface coil probe cooled to 30K. The use of a cryogenic probe represents an economically attractive option to enhance the sensitivity in small animal MRI/MRS. Magn Reson Med, 2008. © 2008 Wiley‐Liss, Inc.

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  1. VesterM SteinmeyerF RoasB ThummesG KlundtK.High temperature superconducting surface coils with liquid nitrogen or pulse tube refrigeration. In: Proc 5th Annual Meeting ISMRM Vancouver Canada;1997:1528.

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Authors
Ratering, D., Baltes, C., Nordmeyer‐Massner, J., Marek, D., & Rudin, M.
Affiliations
  • ETH Zurich (CH)
  • Bruker (Switzerland) (CH)
  • University of Zurich (CH)
Corresponding author
Rudin, Markus
ORCID
Rudin, Markus
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2008-04-17
Volume
59
Issue
6
Pages
1440-1447
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
DOI
10.1002/mrm.21629
OpenAlex
W2043164692
Semantic Scholar
077bcfe8e17bd309e7af292350f220cc7ae0cb20
Cited by
86
References
26
Citations by year
2025: 3 · 2024: 2 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 7
FWCI
4.79
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Magnetic Resonance in Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
  • Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Atomic and Subatomic Physics Research
Keywords
MR spectroscopy, small animal MRI, signal-to-noise ratio, thermal noise reduction, surface coil
MeSH terms
Animals, Body Temperature, Brain Mapping, Cold Temperature, Copper, Equipment Design, Image Enhancement, Magnetic Resonance Imaging, Mice, Inbred C57BL, Magnetic Resonance Spectroscopy, Radio Waves, Phantoms, Imaging, Mice

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