Calculation of susceptibility through multiple orientation sampling (COSMOS): a method for conditioning the inverse problem from measured magnetic field map to susceptibility source image in MRI
Open accessAbstract
Magnetic susceptibility differs among tissues based on their contents of iron, calcium, contrast agent, and other molecular compositions. Susceptibility modifies the magnetic field detected in the MR signal phase. The determination of an arbitrary susceptibility distribution from the induced field shifts is a challenging, ill-posed inverse problem. A method called "calculation of susceptibility through multiple orientation sampling" (COSMOS) is proposed to stabilize this inverse problem. The field created by the susceptibility distribution is sampled at multiple orientations with respect to the polarization field, B(0), and the susceptibility map is reconstructed by weighted linear least squares to account for field noise and the signal void region. Numerical simulations and phantom and in vitro imaging validations demonstrated that COSMOS is a stable and precise approach to quantify a susceptibility distribution using MRI.
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- Authors
- Liu, T., Spincemaille, P., de Rochefort, L., Kressler, B., & Wang, Y.
- Affiliations
- Cornell University (US)
- Corresponding author
- Wang, Yi
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2008-12-18
- Volume
- 61
- Issue
- 1
- Pages
- 196-204
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2152374117
- Cited by
- 454
- References
- 34
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 20 · 2023: 21 · 2022: 29 · 2021: 34 · 2020: 42 · 2019: 33 · 2018: 22 · 2017: 24 · 2016: 27 · 2015: 31 · 2014: 36 · 2013: 35 · 2012: 21
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- magnetic susceptibility mapping, cosmos, ill-posed inverse problems, phase-contrast MRI, magnetic field mapping, weighted least squares, field noise, iron and calcium content
- MeSH terms
- Algorithms, Computer Simulation, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Magnetics, Models, Biological, Sensitivity and Specificity, Reproducibility of Results, Phantoms, Imaging
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