Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: comprehensive phenotyping of vascular and tissular parameters by MRI
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Function and morphology of the cerebral vasculature were studied in the amyloid (Aβ) plaque‐containing double‐transgenic (TG) B6.PS2APP Alzheimer's disease (AD) mouse model with MRI at an age range of 10 to 17 months. Perfusion, blood volume, and average vessel geometry were assessed in the brain and compared to age‐matched controls (wild‐type [WT] C57Bl/6). Additionally, the MR relaxation times T1, T2, and T were measured to detect potential pathological changes that might be associated with Aβ plaque depositions. Both decreased perfusion and decreased blood volume were observed in the occipital cortex in B6.PS2APP mice as compared to controls. A significant decrease in T1 and T2 was found in the frontal cortex and in the subiculum/parasubiculum. Immunohistochemistry confirmed plaque depositions in the cortex and in the subiculum/parasubiculum. In summary, our data indicate a reduced blood supply of B6.PS2APP mice in the occipital cortex that parallels the findings in cortical regions of patients with AD. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
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There is a paucity of studies that have applied ASL to mouse models of AD, although cortical hypo-perfusion has been reported in two amyloid models.
“There is a paucity of studies that have applied ASL to mouse models of AD, although cortical hypo-perfusion has been reported in two amyloid models (Faure et al., 2011, Weidensteiner et al., 2009).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Weidensteiner et al., 2009
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Yoo, C. H., Goh, J., Jahng, G., Jin, S., Lee, D.-K., & Cho, H. (2022) · Journal of the Korean Physical Society · doi:10.1007/s40042-022-00567-y · Cited by 1 · see citing works
FMRI in Mice: Functional Phenotyping of Transgenic Mouse Lines Based on Hemodynamic Readouts
Mueggler, T., Baltes, C., Bosshard, S. C., Princz-Kranz, F. L., Ratering, D., Razoux, F., Sydekum, E., & Rudin, M. (2011) · Advances in neurobiology · doi:10.1007/978-1-4614-1788-0_18 · Cited by 1 · see citing works
Imaging Microvascular Changes Associated with Neurological Diseases
Chugh, B. P. (2012) · TSpace (University of Toronto) · Cited by 1 · see citing works
Marizzoni, M., Forloni, G., & Frisoni, G. B. (2013) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2013.09.003
Review Article Alzheimer's disease biomarkers in animal models: closing the translational gap
Sabbagh, J. J., Kinney, J. W., Cummings, J. L., & Ruvo, L. (2013)
Current Awareness in NMR in Biomedicine
(2010) · NMR in Biomedicine · doi:10.1002/nbm.1449
- Authors
- Weidensteiner, C., Metzger, F., Bohrmann, A. B. B., Kuennecke, B., & von Kienlin, M.
- Affiliations
- F. Hoffmann-La Roche AG (CH)
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2009-05-15
- Volume
- 62
- Issue
- 1
- Pages
- 35-45
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2031516169
- Cited by
- 56
- References
- 43
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 4 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 7 · 2012: 5
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universität Basel
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, cortical hypoperfusion, cerebral vasculature, amyloid plaques, blood volume, cerebral perfusion, vessel geometry, T1 and T2 relaxation, subiculum, parasubiculum, occipital cortex
- MeSH terms
- Alzheimer Disease, Animals, Blood Flow Velocity, Brain, Brain Ischemia, Cerebrovascular Circulation, Disease Models, Animal, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Mice
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