Pseudocontinuous arterial spin labeling with optimized tagging efficiency
Open accessAbstract
The adiabatic inversion of blood in pseudocontinuous arterial spin labeling (PCASL) is highly sensitive to off‐resonance effects and gradient imperfections and this sensitivity can lead to tagging efficiency loss and unpredictable variations in cerebral blood flow estimates. This efficiency loss is caused by a phase tracking error between the RF pulses and the flowing spins. This article introduces a new method, referred to as Optimized PCASL (OptPCASL), that minimizes the phase tracking error by applying an additional compensation RF phase term and in‐plane gradients to the PCASL pulse train. The optimal RF phase and gradient amplitudes are determined using a prescan procedure, which consists of a series of short scans interleaved with automated postprocessing routines integrated to the scanner console. The prescan procedure is shown to minimize the phase tracking error in a robust and time efficient manner. As an example of its application, the use of OptPCASL for the improved detection of functional activation in the visual cortex is demonstrated and temporal signal‐to‐noise ratio (SNR), image SNR, and baseline cerebral blood flow measures are compared to those acquired from conventional PCASL. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
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- Authors
- Shin, D. D., Liu, T. T., Wong, E. C., Shankaranarayanan, A., & Jung, Y.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Shin, David D.
- Jung, Youngkyoo
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2012-01-03
- Volume
- 68
- Issue
- 4
- Pages
- 1135-1144
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- PMC
- PMC3345172
- OpenAlex
- W1975559674
- Cited by
- 37
- References
- 19
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 3 · 2021: 3 · 2020: 2 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1R01MH084796)
- Research grant support from General Electric Healthcare
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- pseudo-continuous arterial spin labeling, tagging efficiency, adiabatic inversion, cerebral blood flow, visual cortex activation, temporal signal-to-noise ratio
- MeSH terms
- Adult, Algorithms, Brain Mapping, Cerebrovascular Circulation, Evoked Potentials, Visual, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Male, Sensitivity and Specificity, Spin Labels, Visual Cortex, Reproducibility of Results, Magnetic Resonance Angiography
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