The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
MR imaging of the amide‐proton transfer effect and the pH‐insensitive nuclear overhauser effect at 9.4 T
Open accessAbstract
The amide proton transfer (APT) effect has emerged as a unique endogenous molecular imaging contrast mechanism with great clinical potentials. However, in vivo quantitative mapping of APT using the conventional asymmetry analysis is difficult due to the confounding nuclear Overhauser effect (NOE) and the asymmetry of the magnetization transfer effect. Here, we showed that the asymmetry of magnetization transfer contrast from immobile macromolecules is highly significant, and the wide spectral separation associated with a high magnetic field of 9.4 T delineates APT and NOE peaks in a Z‐spectrum. Therefore, high‐resolution apparent APT and NOE maps can be obtained from measurements at three offsets. The apparent APT value was greater in gray matter compared to white matter in normal rat brain and was sensitive to tissue acidosis and correlated well with apparent diffusion coefficient in the rat focal ischemic brain. In contrast, no ischemia‐induced contrast was observed in the apparent NOE map. The concentration dependence and the pH insensitivity of NOE were confirmed in phantom experiments. Our results demonstrate that in vivo apparent APT and NOE maps can be easily obtained at high magnetic fields and the pH‐insensitive NOE may be a useful indicator of mobile macromolecular contents. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
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Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI
Zhou, J., Payen, J.-F., Wilson, D. A., Traystman, R. J., & van Zijl, P. C. M. (2003) · Nature Medicine · doi:10.1038/nm907 · Cited by 1,198
Chemical exchange saturation transfer (CEST): what is in a name and what isn't?
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Cited by
van Zijl, P. C. M., Lam, W. W., Xu, J., Knutsson, L., & Stanisz, G. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2017.04.045 · Cited by 339
Zaiss, M., & Bachert, P. (2013) · Physics in Medicine and Biology · doi:10.1088/0031-9155/58/22/r221 · Cited by 323
Noninvasive Detection of Extracellular pH in Human Benign and Malignant Liver Tumors Using CEST MRI
Tang, Y., Xiao, G., Shen, Z., Zhuang, C., Xie, Y., Zhang, X., Yang, Z., Guan, J., Shen, Y., Chen, Y., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.578985 · Cited by 56
Xiao, P., Huang, J., Han, X., Cheu, J. W. S., Liu, Y., Law, L. H., Lai, J. H. C., Li, J., Park, S. W., Wong, C. C. L., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c10493 · Cited by 14
Metadata
- Authors
- Jin, T., Wang, P., Zong, X., & Kim, S.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2012-05-10
- Volume
- 69
- Issue
- 3
- Pages
- 760-770
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W1969935384
- Cited by
- 273
- References
- 31
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Jin, T., Wang, P., Zong, X., & Kim, S. (2013). MR imaging of the amide‐proton transfer effect and the pH‐insensitive nuclear overhauser effect at 9.4 T. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.24315
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