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Cited by 54

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Creatine monohydrate supplementation does not increase muscle strength, lean body mass, or muscle phosphocreatine in patients with myotonic dystrophy type 1

Tarnopolsky, Mark, Mahoney, Douglas, Thompson, Terry, Naylor, Heather, Doherty, Timothy J.·2004·Muscle & Nerve
DOI 10.1002/mus.10527
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Abstract

Creatine monohydrate (CrM) supplementation may increase strength in some types of muscular dystrophy. A recent study in myotonic muscular dystrophy type 1 (DM1) did not find a significant treatment effect, but measurements of muscle phosphocreatine (PCr) were not performed. We completed a randomized, double‐blind, cross‐over trial using 34 genetically confirmed adult DM1 patients without significant cognitive impairment. Participants received CrM (5 g, ∼0.074 g/kg daily) and a placebo for each 4‐month phase with a 6‐week wash‐out. Spirometry, manual muscle testing, quantitative isometric strength testing of handgrip, foot dorsiflexion, and knee extension, handgrip and foot dorsiflexion endurance, functional tasks, activity of daily living scales, body composition (total, bone, and fat‐free mass), serum creatine kinase activity, serum creatinine concentration and clearance, and liver function tests were completed before and after each intervention, and muscle PCr/β‐adenosine triphosphate (ATP) ratios of the forearm flexor muscles were completed at the end of each phase. CrM supplementation did not increase any of the outcome measurements except for plasma creatinine concentration (but not creatinine clearance). Thus, CrM supplementation at 5 g daily does not have any effects on muscle strength, body composition, or activities of daily living in patients with DM1, perhaps because of a failure of the supplementation to increase muscle PCr/β‐ATP content. Muscle Nerve 29: 51–58, 2004

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Metadata

Authors
Tarnopolsky, M., Mahoney, D., Thompson, T., Naylor, H., & Doherty, T. J.
Venue
Muscle & Nerve
Publisher
Wiley
Published
2003-11-21
Volume
29
Issue
1
Pages
51-58
ISSN
  • 0148-639X
  • 1097-4598
DOI
10.1002/mus.10527
Cited by
54
References
8
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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