Cited by 629Peripheral Nerve DisordersIon channel regulation and functionNerve injury and regeneration

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Determinants of conduction velocity in myelinated nerve fibers

Waxman, Stephen G.·1980·Muscle & Nerve

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Abstract

This article reviews the determinants of conduction velocity in myelinated nerve fibers. For fibers exhibiting geometric similarity, conduction velocity is nearly proportional to diameter. However, in classes of geometrically similar fibers, myelin thickness and internode distance are linearly related to diameter. Therefore, it is not possible to assess the relative contributions of each of these factors. The relative effects of changes in each of these parameters on conduction velocity can be assessed from studies on fibers representing different similarity classes or from theoretical parametric studies. These studies show that for a fixed axon diameter, conduction velocity increases with myelin thickness. For a fixed total fiber diameter, there is an optimal ratio of axon diameter to total fiber diameter (and therefore to myelin thickness) at which conduction velocity is maximized. Conduction velocity is dependent on internode distance, with a broad maximum centered around the value observed in normal peripheral fibers. Conduction velocity is also dependent on temperature and the properties of the axonal milieu. Thus, the conduction speed of any given fiber reflects a number of parameters and is not determined by any single structural characteristic.

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Crossref · 10.1002/mus.880030207

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(1976) · Medical Entomology and Zoology · Cited by 1,328
A theory of the effects of fibre size in medullated nerve
Rushton, W. A. H. (1951) · The Journal of Physiology · doi:10.1113/jphysiol.1951.sp004655 · Cited by 1,075
CONDUCTION VELOCITY AND DIAMETER OF NERVE FIBERS
Hursh, J. B. (1939) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1939.127.1.131 · Cited by 916
Evoked action potentials and conduction velocity in human sensory nerves
Buchthal, F., & Rosenfalck, A. (1966) · Brain Research · doi:10.1016/0006-8993(66)90056-4 · Cited by 748
Evidence for saltatory conduction in peripheral myelinated nerve fibres
Huxley, A. F., & Stämpeli, R. (1949) · The Journal of Physiology · doi:10.1113/jphysiol.1949.sp004335 · Cited by 665
Peripheral Neuropathy.
(1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-85-1-141_2 · Cited by 636
AXON DIAMETERS IN RELATION TO THE SPIKE DIMENSIONS AND THE CONDUCTION VELOCITY IN MAMMALIAN A FIBERS
Gasser, H. S., & Grundfest, H. (1939) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1939.127.2.393 · Cited by 452
Relative conduction velocities of small myelinated and non-myelinated fibres in the central nervous system
WAXMAN, S. G., & BENNETT, M. V. L. (1972) · Nature New Biology · doi:10.1038/newbio238217a0 · Cited by 444
Self-citation
Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath.
Ritchie, J. M., & Rogart, R. B. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.1.211 · Cited by 350
THE RÔLE PLAYED BY THE SIZES OF THE CONSTITUENT FIBERS OF A NERVE TRUNK IN DETERMINING THE FORM OF ITS ACTION POTENTIAL WAVE
Gasser, H. S., & Erlanger, J. (1927) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1927.80.3.522 · Cited by 328

Show all 59 references

Research works printed but not linked: 10

Boyd IA, 1964, The relation between conduction velocity and diameter for the three groups of efferent fibres in nerves to mammalian skeletal muscle, J Physiol (Lond), 175, 33
Gilliatt RW, 1959, Peripheral nerve conduction in neurological patients, J Neurol Neurosurg Psychiatry, 22, 344
Hardy WL, 1971, Computed dependence of conduction speed in myelinated axons on geometric parameters, Biophys Soc Abstr, 11, 238a
HenricksenJD:Conduction velocity of motor nerves in normal subjects and in patients with neurological disorders. Ph.D. thesis University of Minnesota 1956.
Lambert EH, 1962, Diagnostic value of electrical stimulation of motor nerves, Electroencephalogr Clin Neurophysiol, 22, 9
Paintal AS, 1978, Physiology and Pathobiology of Axons, 131
Rasminsky M, 1978, Physiology and Pathobiology of Axons, 361
Revenko SV, 1973, Special features of the conduction of nerve impulses from the myelinated part of the axon into the non‐myelinated terminal, Biofizika, 18, 1074
Sumner AJ, 1979, Acute conduction block produced by intraneural injection of EAE serum: a correlative electrophysiologic and morphologic study, Neurology, 29, 581
Waxman SG, 1978, Physiology and Pathobiology of Axons, 125

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Authors: Waxman, S. G.
Affiliations: Stanford Medicine (US)
Corresponding author: Waxman, Stephen G.
ORCID: Waxman, Stephen G.
Venue: Muscle & Nerve
Publisher: Wiley
Published: 1980-03
Volume: 3
Issue: 2
Pages: 141-150
ISSN: 0148-639X (ISSN-L)
1097-4598
DOI: 10.1002/mus.880030207
OpenAlex: W2081771004
Cited by: 629
References: 59
Citations by year: 2026: 30 · 2025: 35 · 2024: 23 · 2023: 30 · 2022: 31 · 2021: 36 · 2020: 36 · 2019: 32 · 2018: 38 · 2017: 23 · 2016: 23 · 2015: 24 · 2014: 22 · 2013: 19 · 2012: 18
FWCI: 5.99
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8992 d)
Locations: Muscle & Nerve (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Peripheral Nerve Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: conduction velocity, myelinated axons, myelin thickness, internode distance, axon diameter, geometric similarity, peripheral nerves, temperature effects
MeSH terms: Animals, Computers, Fishes, Ion Channels, Models, Neurological, Myelin Sheath, Nerve Fibers, Myelinated, Nerve Regeneration, Neural Conduction, Ranvier's Nodes, Temperature, Time Factors

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Determinants of conduction velocity in myelinated nerve fibers

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