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Determinants of conduction velocity in myelinated nerve fibers
Abstract
This article reviews the determinants of conduction velocity in myelinated nerve fibers. For fibers exhibiting geometric similarity, conduction velocity is nearly proportional to diameter. However, in classes of geometrically similar fibers, myelin thickness and internode distance are linearly related to diameter. Therefore, it is not possible to assess the relative contributions of each of these factors. The relative effects of changes in each of these parameters on conduction velocity can be assessed from studies on fibers representing different similarity classes or from theoretical parametric studies. These studies show that for a fixed axon diameter, conduction velocity increases with myelin thickness. For a fixed total fiber diameter, there is an optimal ratio of axon diameter to total fiber diameter (and therefore to myelin thickness) at which conduction velocity is maximized. Conduction velocity is dependent on internode distance, with a broad maximum centered around the value observed in normal peripheral fibers. Conduction velocity is also dependent on temperature and the properties of the axonal milieu. Thus, the conduction speed of any given fiber reflects a number of parameters and is not determined by any single structural characteristic.
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“The probable result of both myelination and increasing axonal calibre would be an increase in axonal conduction speed (Waxman, 1980).”
From The social brain in adolescence: evidence from functional magnetic resonance imaging and behavioural studies (2011) · cites this paper as Waxman, 1980
In the citing paper
“Myelin modulates the speed of neural impulse conduction (Smith and Koles, 1970; Waxman, 1980), provides metabolic support to axons (Fünfschilling et al., 2012), and exhibits adaptive plasticity (Gibson et al., 2014);”
From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Waxman, 1980
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Metadata
- Authors
- Waxman, S. G.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Waxman, Stephen G.
- ORCID
- Waxman, Stephen G.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 1980-03
- Volume
- 3
- Issue
- 2
- Pages
- 141-150
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2081771004
- Cited by
- 629
- References
- 59
- Citations by year
- 2026: 30 · 2025: 35 · 2024: 23 · 2023: 30 · 2022: 31 · 2021: 36 · 2020: 36 · 2019: 32 · 2018: 38 · 2017: 23 · 2016: 23 · 2015: 24 · 2014: 22 · 2013: 19 · 2012: 18
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Peripheral Nerve Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Keywords
- conduction velocity, myelinated axons, myelin thickness, internode distance, axon diameter, geometric similarity, peripheral nerves, temperature effects
- MeSH terms
- Animals, Computers, Fishes, Ion Channels, Models, Neurological, Myelin Sheath, Nerve Fibers, Myelinated, Nerve Regeneration, Neural Conduction, Ranvier's Nodes, Temperature, Time Factors
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