The DOI matches its Crossref record, with a small difference in title or year; 23 of the 23 references it cites were found in a registry or an index.
Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections
Abstract
The effects of aging on the total number and size of fibers, and the proportion and distribution of type 1 (slow twitch) and type 2 (fast twitch) fibers were studied in cross sections (15 μ thick) of autopsied whole m. vastus lateralis from two age groups. Each group consisted of six, previously physically healthy males (mean age 72 ± 1 years and 30 ± 6 years, respectively). The size of the muscles of the older individuals was 18% smaller ( P < 0.01) and the total number of fibers was 25% lower ( P < 0.01) than those of the young individuals (mean number 364,000 ± 50,000 vs 478,000 ± 56,000). There was, however, no significant difference in the mean fiber size (indirectly determined) orthe proportion of the two fiber types, though a preferential reduction in type 2 fiber number in the aged individuals was seen. The relative occurrence of the fiber types at various depths in the aged muscles was found to be more even than in muscles from the young individuals. The results suggest that the aging atrophy in m. vastus lateralis , at least up to the age of 70, is primarily the result of a loss of fibers.
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“During the aging process, changes both in the contractile efficiency of muscle fibers and in tissue quality, such as pericellular fat infiltration, may also contribute to altered muscle function (12, 13).”
From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [12]
In the citing paper
“Both muscle mass and strength decline with age.”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [153]
Citations
Cites
Data on the distribution of fibre types in thirty-six human muscles
Johnson, M. A., Polgar, J., Weightman, D., & Appleton, D. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90023-3 · Cited by 2,200
THE SPECIFICITY OF THE HISTOCHEMICAL METHOD FOR ADENOSINE TRIPHOSPHATAS
Padykula, H. A., & Herman, E. (1955) · Journal of Histochemistry & Cytochemistry · doi:10.1177/3.3.170 · Cited by 1,201
Physiological changes in ageing muscles
Campbell, M. J., McComas, A. J., & Petito, F. (1973) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.36.2.174 · Cited by 738
Development, Innervation, and Activity-Pattern Induced Changes in Skeletal Muscle
Jolesz, F. A., & Sreter, F. A. (1981) · Annual Review of Physiology · doi:10.1146/annurev.ph.43.030181.002531 · Cited by 329
Lexell, J. E., Henriksson-Larsén, K., & Sjöstróm, M. (1983) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1983.tb07185.x · Cited by 302
Self-citationBrown, W. F. (1972) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.35.6.845 · Cited by 283
Morphology and enzymatic capacity in arm and leg muscles in 78–81 year old men and women
Grimby, G., Danneskiold‐Samsøe, B., HVID, K., & Saltin, B. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07054.x · Cited by 280
Larsson, L. (1978) · PubMed · Cited by 231
Histochemical and Ultrastructural Changes in Senile Human Skeletal Muscle
Tomonaga, M. (1977) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1977.tb00274.x · Cited by 224
Morphology and physiology of skeletal muscle in aging rodents
Caccia, M. R., Harris, J. B., & Johnson, M. A. (1979) · Muscle & Nerve · doi:10.1002/mus.880020308 · Cited by 168
Research works printed but not linked: 3
- Alnaqeeb MA, 1980, Interrelation of muscle fibre types, diameter and number in ageing white rats, J Physiol (Lond), 310, 56
- Sica REP, 1976, The effects of ageing upon the human soleus muscle, Medicina (B Aires), 36, 443
- Snedecor GW, 1967, Statistical Methods
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Exercise and Physical Activity for Older Adults
Chodzko-Zajko, W. J., Proctor, D. N., Fiatarone Singh, M. A., Minson, C. T., Nigg, C. R., Salem, G. J., & Skinner, J. S. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181a0c95c · Cited by 5,153
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
“This is due to a decline in both muscle fiber size and number (10).”
BackgroundWhat is the cause of the ageing atrophy?
Lexell, J. E., Taylor, C. C., & Sjöstróm, M. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90132-3 · Cited by 2,080
Self-citationSarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377
Metadata
- Authors
- Lexell, J., Henriksson‐Larsén, K., Winblad, B., & Sjöström, M.
- Affiliations
- Umeå University (SE)
- Corresponding author
- Lexell, Jan
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 1983-10
- Volume
- 6
- Issue
- 8
- Pages
- 588-595
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2028656620
- Cited by
- 582
- References
- 23
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 22 · 2023: 13 · 2022: 25 · 2021: 34 · 2020: 15 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 19 · 2015: 23 · 2014: 19 · 2013: 16 · 2012: 22
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, fiber type distribution, vastus lateralis, muscle atrophy, fiber number, fiber diameter, muscle cross-section, age-related muscle loss
- MeSH terms
- Adult, Aged, Aging, Arteriosclerosis, Cell Count, Humans, Ischemia, Male, Muscles, Nerve Degeneration
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