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Cited by 28Peripheral Nerve DisordersNeuroscience and Neural EngineeringNerve injury and regeneration

Conduction studies in peripheral cat nerve using implanted electrodes: III. The effects of prolonged constriction on the distal nerve segment

Krarup, Christian, Loeb, Gerald E., Pezeshkpour, Gholam H.·1989·Muscle & Nerve
DOI 10.1002/mus.880121108
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Abstract

Electrophysiological properties were monitored in detail in chronically constricted peripheral nerves by implanted, multicontact nerve cuff electrodes and correlated with morphometric histology in selected cases. The physiological and histological responses in nerve to a range of constricting cuffs of standard sizes were readily graded. The initial response to any significant constriction was a transient, focal conduction slowing or block at the constriction, followed by more protracted distal effects; the latter ranged from loss of excitability consistent with "dying-back" degeneration to reductions in conduction velocity consistent with histologically observed atrophy. Smaller myelinated fibers tended to have similar but less pronounced changes than larger diameter fibers. Recordings from ventral and dorsal roots showed that distal degeneration was more pronounced in motor than in sensory fibers of similar caliber. Electronmicroscopical measurements showed that basal laminas were relatively preserved around even the most atrophic and demyelinated axons. Perimeter measurements of the basal lamina could be used to estimate the diameter of the original nerve fiber.

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Crossref · 10.1002/mus.880121108

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  • Nerves can be damaged by the presence of a cuff because of the delicacy of nerve tissue and the physical properties of the electrodes, especially in limb peripheral nerves subjected to a wide range of motion.

    “In spite of the fact that cuff electrodes have been implanted in patients for decades, nerves can be damaged by the presence of the cuff due to the delicacy of the nerve tissue and the physical properties of the electrodes (Nielson et al., 1976; Waters et al., 1985; Krarup et al., 1989; Naples et al., 1990; Larsen et al., 1998) , especially in peripheral nerves of the limbs, subjected to a wide”

    From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Krarup et al., 1989

  • Chronic implantation of snug cuffs modifies nerve shape and produces loss of large nerve fibers, which are the most sensitive to compression.

    “Although snug-fitting nerve cuffs have been advocated to reduce the stimulus charge injection or to obtain a high signal-to-noise ratio for neural recordings (Naples et al., 1990) , different studies have shown that chronic implantation of snug cuffs modifies the nerve shape and produces a loss of large nerve fibers, which are the most sensitive to compression (Krarup et al., 1989; Grill and Mort”

    From A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems (2005) · cites this paper as Krarup et al., 1989

  • Nerve compression is associated with axonal death and inflammation.

    “Nerve compression is associated with axonal death and inflammation (Krarup et al., 1989; Grill and Mortimer, 2000; Vince et al., 2005), which can in turn exacerbate FBR to the implant (Romero et al., 2001).”

    From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Krarup et al., 1989

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Authors
Krarup, C., Loeb, G. E., & Pezeshkpour, G. H.
Affiliations
  • Brigham and Women's Hospital (US)
  • National Institutes of Health (US)
  • Armed Forces Institute of Pathology (US)
Corresponding author
Krarup, Christian
ORCID
Venue
Muscle & Nerve
Publisher
Wiley
Published
1989-11
Volume
12
Issue
11
Pages
915-928
ISSN
  • 0148-639X (ISSN-L)
  • 1097-4598
DOI
10.1002/mus.880121108
OpenAlex
W2002233504
Cited by
28
References
32
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2015: 1 · 2014: 2
FWCI
0.42
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5460 d)
Locations
  • Muscle & Nerve (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords
cuff electrodes, nerve atrophy, dying-back degeneration, conduction velocity, nerve excitability, myelinated axons, basement membrane, demyelination
MeSH terms
Animals, Atrophy, Cats, Constriction, Electrodes, Implanted, Electrophysiology, Nerve Fibers, Neural Conduction, Peripheral Nerves

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