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Cited by 96Spinal Cord Injury ResearchBarrier Structure and Function StudiesAdvanced MRI Techniques and Applications

Blood–spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast‐enhanced MRI

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Cohen, David M., Patel, Chirag B., Ahobila‐Vajjula, Pallavi, Sundberg, Laura M., Chacko, Tessy, Liu, Shi‐Jie, Narayana, Ponnada A.·2009·NMR in Biomedicine
DOI 10.1002/nbm.1343PMC PMC2741317
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Abstract

After a primary traumatic injury, spinal cord tissue undergoes a series of pathobiological changes, including compromised blood–spinal cord barrier (BSCB) integrity. These vascular changes occur over both time and space. In an experimental model of spinal cord injury (SCI), longitudinal dynamic contrast‐enhanced MRI (DCE‐MRI) studies were performed up to 56 days after SCI to quantify spatial and temporal changes in the BSCB permeability in tissue that did not show any visible enhancement on the post‐contrast MRI (non‐enhancing tissue). DCE‐MRI data were analyzed using a two‐compartment pharmacokinetic model. These studies demonstrate gradual restoration of BSCB with post‐SCI time. However, on the basis of DCE‐MRI, and confirmed by immunohistochemistry, the BSCB remained compromised even at 56 days after SCI. In addition, open‐field locomotion was evaluated using the 21‐point Basso–Beattie–Bresnahan scale. A significant correlation between decreased BSCB permeability and improved locomotor recovery was observed. Copyright © 2008 John Wiley & Sons, Ltd.

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  • The blood-spinal cord barrier can remain compromised even at 56 days after spinal cord injury as assessed using DCE-MRI.

    “The BSCB can remain compromised even at 56 days after SCI as assessed using DCE-MRI (117).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [117]

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Cited by

Sorted by citations

Authors
Cohen, D. M., Patel, C. B., Ahobila‐Vajjula, P., Sundberg, L. M., Chacko, T., Liu, S., & Narayana, P. A.
Affiliations
The University of Texas Health Science Center at Houston (US)
Corresponding author
Narayana, Ponnada A.
ORCID
Venue
NMR in Biomedicine
Publisher
Wiley
Published
2008-11-20
Volume
22
Issue
3
Pages
332-341
ISSN
  • 0952-3480 (ISSN-L)
  • 1099-1492
DOI
10.1002/nbm.1343
PMC
PMC2741317
OpenAlex
W2159640450
Cited by
96
References
5
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 3 · 2021: 11 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 5 · 2012: 6
FWCI
4.97
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • NMR in Biomedicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH/NINDS (NS045624)
  • NIH/NCRR (S10 RR17205)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
blood-spinal cord barrier, spinal cord injury, dynamic contrast-enhanced MRI, two-compartment model, locomotor recovery, spinal cord blood flow, immunohistochemistry
MeSH terms
Albumins, Animals, Blood-Brain Barrier, Contrast Media, Extravasation of Diagnostic and Therapeutic Materials, Gadolinium, Magnetic Resonance Imaging, Male, Permeability, Sodium Chloride, Spinal Cord, Spinal Cord Injuries, Time Factors, Reproducibility of Results, Rats, Sprague-Dawley, Rats

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