Dendritic spine morphogenesis and plasticity
Abstract
Dendritic spines are small protrusions off the dendrite that receive excitatory synaptic input. Spines vary in size, likely correlating with the strength of the synapses they form. In the developing brain, spines show highly dynamic behavior thought to facilitate the formation of new synaptic contacts. Recent studies have illuminated the numerous molecules regulating spine development, many of which converge on the regulation of actin filaments. In addition, interactions with glial cells are emerging as important regulators of spine morphology. In many cases, spine morphogenesis, plasticity, and maintenance also depend on synaptic activity, as shown by recent studies demonstrating changes in spine dynamics and maintenance with altered sensory experience. © 2005 Wiley Periodicals, Inc. J Neurobiol 64: 47–57, 2005
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Small GTPases play a critical role in neuronal trafficking and spine morphogenesis.
“small GTPases play a critical role in neuronal trafficking and spine morphogenesis [23], [24], [25], [26].”
From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [24]
Cites
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 2× · see citing works
“DOI 10.1002/neu.20149 47 Yuste, 2004), it is now known that it is the size of the spine head that correlates with synaptic strength (Schikorski and Stevens, 1997; Matsuzaki et al., 2001).”
BackgroundInfluentialControl of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
PSD-95 Involvement in Maturation of Excitatory Synapses
El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., & Bredt, D. S. (2000) · Science · doi:10.1126/science.290.5495.1364 · Cited by 1,303 · see citing works
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · see citing works
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905 · see citing works
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
Murai, K. K., Nguyen, L. N., Irie, F., Yamaguchi, Y., & Pasquale, E. B. (2003) · Nature Neuroscience · doi:10.1038/nn994 · Cited by 516 · see citing works
Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., & Huganir, R. L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01168-6 · Cited by 466 · see citing works
The small pyramidal neuron of the rat cerebral cortex: The synapses upon dendritic spines
Peters, A., & Kaiserman-Abramof, I. R. (1969) · Zeitschrift f�r Zellforschung und Mikroskopische Anatomie · doi:10.1007/bf00344370 · Cited by 441 · see citing works
Developmental regulation of spine motility in the mammalian central nervous system
Dunaevsky, A., Tashiro, A., Majewska, A., Mason, C., & Yuste, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13438 · Cited by 412 · see citing works
Self-citationRegulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin
Halpain, S., Hipolito, A., & Saffer, L. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09835.1998 · Cited by 408 · cited 6× · see citing works
“Because many forms of spine plasticity and stabilization require calcium-dependent molecules (Halpain et al., 1998; Jourdain et al., 2003; Lin et al., 2004), this Ephrin-B/ EphB/NMDA receptor signaling cascade may present a concerted mechanism through which these diverse molecules can modulate the…”
BackgroundInfluentialKrucker, T., Siggins, G. R., & Halpain, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100139797 · Cited by 374 · see citing works
Shen, K., Teruel, M. N., Subramanian, K., & Meyer, T. (1998) · Neuron · doi:10.1016/s0896-6273(00)80569-3 · Cited by 350 · see citing works
Bonhoeffer, T., & Yuste, R. (2002) · Neuron · doi:10.1016/s0896-6273(02)00906-6 · Cited by 337 · see citing works
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280 · see citing works
Dendritic stability in the adult olfactory bulb
Mizrahi, A., & Katz, L. C. (2003) · Nature Neuroscience · doi:10.1038/nn1133 · Cited by 161 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Experience-dependent structural plasticity in the cortex
Fu, M., & Zuo, Y. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.02.001 · Cited by 322 · see citing works
Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning
Lerch, J. P., Yiu, A. P., Martinez-Canabal, A., Pekar, T., Bohbot, V. D., Frankland, P. W., Henkelman, R. M., Josselyn, S. A., & Sled, J. G. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.086 · Cited by 300 · see citing works
Spatiotemporal dynamics of dendritic spines in the living brain
Chen, C.-C., Lu, J., & Zuo, Y. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00028 · Cited by 88 · see citing works
DSCAM Contributes to Dendrite Arborization and Spine Formation in the Developing Cerebral Cortex
Maynard, K. R., & Stein, E. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2811-12.2012 · Cited by 67 · see citing works
Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development
Jain, S., Yoon, S. Y., Zhu, L., Brodbeck, J., Dai, J., Walker, D., & Huang, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046340 · Cited by 43 · see citing works
Sun, G., He, Y., Ma, X. K., Li, S., Chen, D., Gao, M., Qiu, S., Yin, J., Shi, J., & Wu, J. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12720 · Cited by 42 · see citing works
Waller, J. A., Chen, F., & Sánchez, C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.012 · Cited by 25 · see citing works
- Authors
- Lippman, J., & Dunaevsky, A.
- Affiliations
- Brown University (US)
- Corresponding author
- Dunaevsky, Anna
- ORCID
- Dunaevsky, Anna
- Venue
- Journal of Neurobiology
- Publisher
- Wiley
- Published
- 2005-05-09
- Volume
- 64
- Issue
- 1
- Pages
- 47-57
- ISSN
- 0022-3034 (ISSN-L)
- 1097-4695
- OpenAlex
- W1976476169
- Cited by
- 142
- References
- 16
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 14
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- dendritic spines, spine morphogenesis, synaptic plasticity, actin cytoskeleton, synaptic development, spine dynamics, excitatory synapses
- MeSH terms
- Animals, Models, Neurological, Morphogenesis, Nerve Tissue Proteins, Neuroglia, Neuronal Plasticity, Steroids, Synapses, Cell Adhesion Molecules, Neuronal, Receptors, Glutamate, Monomeric GTP-Binding Proteins, Ephrins, Dendritic Spines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
