Spine Motility
Open accessAbstract
Throughout the history of neuroscience, dendritic spines have been considered stable structures, but in recent years, imaging techniques have revealed that spines are constantly changing shape. Spine motility is difficult to categorize, has different forms, and possibly even represents multiple phenomena. It is influenced by synaptic transmission, intracellular calcium, and a multitude of ions and other molecules. An actin-based cascade mediates this phenomenon, and while the precise signaling pathways are still unclear, the Rho family of GTPases could well be a "common denominator" controlling spine morphology. One role of spine motility might be to enable a searching function during synaptogenesis, allowing for more efficacious neuronal connectivity in the neuronal thicket. This idea revisits concepts originally formulated by Cajal, who proposed over a hundred years ago that spines might help to increase and modify synaptic connections.
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Organotypic hippocampal slice cultures undergo key developmental steps similar to in vivo, including synapse maturation.
“Organotypic hippocampal slice cultures are known to undergo key developmental steps similar to those observed in vivo, including synapse maturation28–31, and have been previously used to study ramified microglia function32.”
From Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction (2018) · cites this paper as [28]
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- Authors
- Bonhoeffer, T., & Yuste, R.
- Affiliations
- Max Planck Institute of Neurobiology (DE)
- Max Planck Society (DE)
- Corresponding author
- Bonhoeffer, Tobias
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 35
- Issue
- 6
- Pages
- 1019-1027
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W151176851
- Cited by
- 337
- References
- 103
- Citations by year
- 2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 10 · 2017: 2 · 2016: 9 · 2015: 16 · 2014: 12 · 2013: 12 · 2012: 18
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 3972 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Eye Institute (R01EY013237, EY 13237)
- National Institute of Neurological Disorders and Stroke (NS 40726, R01NS040726)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- dendritic spines, spine motility, dendritic spine morphology, synaptic transmission, intracellular calcium, actin cytoskeleton, Rho GTPases, synaptogenesis, neuronal connectivity, Santiago Ramón y Cajal
- MeSH terms
- Animals, Central Nervous System, Dendrites, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses
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