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Gap junctions are required for the propagation of spreading depression
Abstract
Spreading depression (SD) is a slowly propagating depression of cerebral neuronal activity and transmembrance ionic gradients, that arises in response to a variety of noxious stimuli. SD bears a strong resemblance to gap junction‐mediated calcium waves among cultured astrocytes. Here, we show that gap junction‐mediated intercellular diffusion is necessary for the generation of SD. Waves of SD in the isolated chicken retina were blocked by five different inhibitors of gap junctional coupling, which was assessed by the intercellular transit of Lucifer Yellow (LY). Each of these gap junction blockers inhibited both the migration of SD and the diffusion of LY in a dose‐dependent manner. In contrast, glutamate‐evoked calcium influx into retinal cells was not affected by these compounds. The results indicate that intercellular coupling through gap junctions is required for SD. Gap junction‐mediated communication might therefore constitute an important mechanism in both normative and pathological brain function. © 1995 John Wiley & Sons, Inc.
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Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545
Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
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The induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774
Fabricius, M., Fuhr, S., Bhatia, R., Boutelle, M., Hashemi, P., Strong, A. J., & Lauritzen, M. (2006) · Brain · doi:10.1093/brain/awh716 · Cited by 420
Role of glial cells in cerebral ischemia
Nedergaard, M., & Dirnagl, U. (2005) · Glia · doi:10.1002/glia.20205 · Cited by 285
Self-citationGlial Connexins and Pannexins in the Healthy and Diseased Brain
Giaume, C., Naus, C. C., Sáez, J. C., & Leybaert, L. (2021) · Physiological Reviews · doi:10.1152/physrev.00043.2018 · Cited by 154
Astroglia In Neurological Diseases
Verkhratsky, A., Rodríguez, J. J., & Parpura, V. (2013) · Future Neurology · doi:10.2217/fnl.12.90 · Cited by 140
Metadata
- Authors
- Nedergaard, M., Cooper, A. J. L., & Goldman, S. A.
- Venue
- Journal of Neurobiology
- Publisher
- Wiley
- Published
- 1995-12
- Volume
- 28
- Issue
- 4
- Pages
- 433-444
- ISSN
- 0022-3034 (ISSN-L)
- 1097-4695
- OpenAlex
- W1997899631
- Cited by
- 192
- References
- 2
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nedergaard, M., Cooper, A. J. L., & Goldman, S. A. (1995). Gap junctions are required for the propagation of spreading depression. Journal of Neurobiology. https://doi.org/10.1002/neu.480280404
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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