Astroglia In Neurological Diseases
Open accessAbstract
Astroglia encompass a subset of versatile glial cells that fulfill a major homeostatic role in the mammalian brain. Since any brain disease results from failure in brain homeostasis, astroglial cells are involved in many, if not all, aspects of neurological and/or psychiatric disorders. In this article, the roles of astrocytes as homeostatic cells in healthy and diseased brains are surveyed. These cells can mount the defence response to the insult of the brain, astrogliosis, when and where they display hypertrophy. Interestingly, astrocytes can alternatively display atrophy in some pathological conditions. Various pathologies, including Alexander and Alzheimer's diseases, amyotrophic lateral sclerosis, stroke and epilepsy, to mention a few, are discussed. Astrocytes could represent a novel target for medical intervention in the treatment of brain disorders.
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Among 5-HT receptor subtypes, the 5-HT1, 5-HT2, 5-HT6, and 5-HT7 subtypes are expressed on brain and spinal astrocytes in humans and rodents.
“Among these 5-HT receptor subtypes, the 5-HT 1 , 5-HT 2 , 5-HT 6 , and 5-HT 7 subtypes are expressed on brain and spinal astrocytes in humans and rodents.”
From Major depressive disorder: hypothesis, mechanism, prevention and treatment (2024) · cites this paper as [57]
The section “Astrocytes: main homeostatic cells of the CNS” discusses neurotransmitter homeostasis but does not identify 5-HT receptors on astrocytes. Searches of the indexed full text for 5-HT, serotonin, and the named receptor subtypes found no passage addressing their expression in human or rodent brain or spinal astrocytes. No page number was supplied for the relevant section. (LLM, conf=0.76)
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- Kettenmann H Ransom BR Neuroglia 2012 Oxford University Press Oxford, UK 3rd Edition Most comprehensive reference book in the field.
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Gómez‐Gonzalo, M., Martin‐Fernandez, M., Martínez‐Murillo, R., Mederos, S., Hernández‐Vivanco, A., Jamison, S., Fernandez, A. P., Serrano, J., Calero, P., Futch, H. S., et al. (2017) · Glia · doi:10.1002/glia.23112 · Cited by 114 · see citing works
Ugolini, F., Lana, D., Nardiello, P., Nosi, D., Pantano, D., Casamenti, F., & Giovannini, M. G. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00372 · Cited by 50 · see citing works
- Authors
- Verkhratsky, A., Rodríguez, J. J., & Parpura, V.
- Affiliations
- Ikerbasque (ES)
- Ikerbasque, Basque Foundation for Science, 48011, Bilbao, Spain
- Corresponding author
- Verkhratsky, Alexei
- Venue
- Future Neurology
- Publisher
- Informa UK Limited
- Published
- 2013-02-28
- Volume
- 8
- Issue
- 2
- Pages
- 149-158
- ISSN
- 1479-6708 (ISSN-L)
- 1748-6971
- PMC
- PMC3645493
- OpenAlex
- W2134205638
- Cited by
- 140
- References
- 97
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 16 · 2016: 11 · 2015: 16 · 2014: 24 · 2013: 7
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Future Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ASEP (submittedVersion, public-domain)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Alzheimer‘s Research Trust (UK) Programme Grant
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- astrocytes, astroglia, brain homeostasis, astrocyte activation, astrocyte hypertrophy, Alexander disease, Alzheimer's disease, amyotrophic lateral sclerosis, stroke, epilepsy, glial cells, neurological disorders, therapeutic target
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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