The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Midlife obesity and dementia: Meta‐analysis and adjusted forecast of dementia prevalence in the united states and china
Open accessAbstract
Objective: Obesity is a risk factor of dementia. Current forecasts of dementia prevalence fail to take the rising obesity prevalence into account. Design and Methods: Embase and Medline were searched for observational studies on the association between overweight (BMI 25‐30 kg/m 2) or obesity (BMI > 30 kg/m 2) and dementia and pooled the effect sizes by meta‐analysis. The population attributable risk (PAR) was calculated for different time points and adjusted them for confounders. Based on current prevalence rates of dementia and demographic forecasts, patient numbers were calculated and adjusted by the growth rates of PAR. Results: Compared to normal weight, midlife obesity increases the risk of dementia later in life (BMI 25‐30: RR = 1.34 [95% CI 1.08, 1.66], BMI > 30: RR = 1.91 [1.4, 2.62]). If obesity is included into forecast models, the prevalence of dementia is estimated to be 7.1 million (6.9, 7.3) and 11.3 million (10.9, 11.7) for the United States in 2030 and 2050, respectively. In China, the estimate is 13.1 million (12.8, 13.3) in 2030 and 26.2 million (25.1, 27.4) in 2050. These figures are 9% and 19% higher for the United States and China, respectively, than forecasts that rely solely on the demographic change. Conclusion: The past and ongoing increase in midlife obesity prevalence will contribute significantly to the future prevalence of dementia and public health measures to reduce midlife obesity are simultaneously primary prevention measures to reduce the risk of dementia.
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Global burden of obesity in 2005 and projections to 2030
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“The Pr(E) were directly adopted (13,14) and applied to equation II (see Supporting Information Table 3).”
BackgroundMethodInfluentialThe nutrition transition: worldwide obesity dynamics and their determinants
Popkin, B. M., & Gordon-Larsen, P. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802804 · Cited by 1,538
Obesity and Vascular Risk Factors at Midlife and the Risk of Dementia and Alzheimer Disease
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., Helkala, E.-L., Tuomilehto, J., Soininen, H., & Nissinen, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1556 · Cited by 1,291
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Midlife and Late-Life Obesity and the Risk of Dementia: Cardiovascular Health Study
Fitzpatrick, A. L., Kuller, L. H., Lopez, O. L., Diehr, P., O’Meara, E. S., Longstreth, W. T., & Luchsinger, J. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.582 · Cited by 796
Body Mass Index in Midlife and Risk of Alzheimer Disease and Vascular Dementia
Whitmer, R., Gunderson, E., Quesenberry, C., Zhou, J., & Yaffe, K. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362047 · Cited by 430
Kloppenborg, R. P., van den Berg, E., Kappelle, L. J., & Biessels, G. J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.049 · Cited by 368
Adherence to healthy lifestyle habits in US adults, 1988–2006
King, D. E., Mainous, A. G., Carnemolla, M., & Everett, C. J. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2008.11.013 · Cited by 336 · cited 1×
“We did not consider further risk factors in our forecast because they either have not increased as strongly and world-wide as obesity in the last decades (34), or are strongly correlated with obesity, such as diet and exercise.”
BackgroundBody Mass Index, Other Cardiovascular Risk Factors, and Hospitalization for Dementia
Rosengren, A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.3.321 · Cited by 207
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Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596
Metadata
- Authors
- Loef, M., & Walach, H.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-01
- Volume
- 21
- Issue
- 1
- Pages
- E51-5
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2096166726
- Cited by
- 178
- References
- 10
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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