The visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome
Open accessAbstract
Objective: Visceral fat accumulation is more strongly related to insulin resistance than to excess total adiposity. The visceral adiposity index (VAI) has recently been suggested as an indicator of the visceral adiposity measured by magnetic resonance imaging. To evaluate whether the VAI could replace visceral computed tomography (CT) scanning and predict insulin resistance in young women with polycystic ovary syndrome (PCOS) was presented. Design and Methods: One hundred and eighty Korean women aged 16‐41 years who were diagnosed with PCOS using the Rotterdam criteria were included. The VAI was derived from a formula using body mass index, waist circumference, triglycerides, and high‐density lipoprotein cholesterol. Visceral adiposity was defined as a visceral fat area (VFA) measuring > 100 cm 2 by CT scanning. Insulin sensitivity was evaluated by insulin‐mediated glucose utilization (M value), which was obtained using a euglycemic hyperinsulinemic clamp. Results: The VAI positively correlated with VFA, the visceral‐to‐subcutaneous fat ratio, and systolic and diastolic blood pressure, and negatively correlated with the M value. In a linear regression analysis, the VAI was an independent determinant of the insulin sensitivity after controlling for age, systolic blood pressure, fasting glucose, fasting insulin, and testosterone levels. In a logistic regression analysis, the VAI odds ratio was 3.5 (95% CI 1.2‐9.8) for predicting visceral adiposity after controlling for the various metabolic parameters and testosterone. Conclusion: The VAI can replace visceral CT scanning as a marker for visceral adiposity, and it predicts insulin resistance in young women with PCOS.
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VAI can effectively replace visceral computed tomography as a marker for visceral adiposity and has predictive capacity for IR in young women with PCOS.
“Oh et al. initially proposed that VAI could effectively replace visceral computed tomography as a marker for visceral adiposity, demonstrating its predictive capacity for IR in young women with PCOS [31].”
VAI is superior to BMI in predicting IR and MetS.
“The evidence indicates that VAI is superior to BMI in predicting IR and MetS.”
Cites
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“Women with PCOS have excessive visceral fat accumulation, even if they are of normal weight, and visceral adiposity is associated with more pronounced hyperandrogenism and insulin resistance than subcutaneous or peripheral fat accumulation (12,23,24).”
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Epigenetic and Transcriptional Alterations in Human Adipose Tissue of Polycystic Ovary Syndrome
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“Oh et al. initially proposed that VAI could effectively replace visceral computed tomography as a marker for visceral adiposity, demonstrating its predictive capacity for IR in young women with PCOS [31].”
- Authors
- Oh, J., Sung, Y., & Lee, H. J.
- Affiliations
- Ewha Womans University (KR)
- Corresponding author
- Oh, Jee‐Young
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-04-13
- Volume
- 21
- Issue
- 8
- Pages
- 1690-1694
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W1538464857
- Cited by
- 154
- References
- 6
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 13 · 2023: 12 · 2022: 12 · 2021: 10 · 2020: 16 · 2019: 11 · 2018: 16 · 2017: 8 · 2016: 15 · 2015: 7 · 2014: 10 · 2013: 6
- FWCI
- 15.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Keywords
- visceral adiposity index, insulin resistance, polycystic ovary syndrome, visceral fat, insulin sensitivity, visceral-to-subcutaneous fat ratio, young women, hyperinsulinemic-euglycemic clamp, visceral fat area, blood pressure, testosterone
- MeSH terms
- Adolescent, Adult, Blood Glucose, Cross-Sectional Studies, Female, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, Obesity, Polycystic Ovary Syndrome, Triglycerides, Tomography Scanners, X-Ray Computed, Body Mass Index, Linear Models, Asian People, Subcutaneous Fat, Intra-Abdominal Fat, Adiposity, Waist Circumference, Young Adult, Republic of Korea
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