Hypertriglyceridemic Waist: A Marker of the Atherogenic Metabolic Triad (Hyperinsulinemia; Hyperapolipoprotein B; Small, Dense LDL) in Men?
Abstract
Background —The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as screening tools for the identification of men characterized by a metabolic triad of nontraditional risk factors (elevated insulin and apolipoprotein [apo] B and small, dense LDL particles). Methods and Results —Results of the metabolic study (study 1) conducted on 185 healthy men indicate that a large proportion (>80%) of men with waist circumference values ≥90 cm and with elevated TG levels (≥2.0 mmol/L) were characterized by the atherogenic metabolic triad. Validation of the model in an angiographic study (study 2) on a sample of 287 men with and without coronary artery disease (CAD) revealed that only men with both elevated waist and TG levels were at increased risk of CAD (odds ratio of 3.6, P <0.03) compared with men with low waist and TG levels. Conclusions —It is suggested that the simultaneous measurement and interpretation of waist circumference and fasting TG could be used as inexpensive screening tools to identify men characterized by the atherogenic metabolic triad (hyperinsulinemia, elevated apo B, small, dense LDL) and at high risk for CAD.
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Adding biochemical markers such as plasma triglyceride levels to waist circumference (hypertriglyceridaemic waist) has been suggested as a useful method for identifying individuals with excess visceral adipose tissue and ectopic fat.
“Adding biochemical markers, such as plasma triglyceride levels, to the measurement of waist circumference—a phenotype described as hypertriglyceridaemic waist—has been suggested as a useful method for identification of individuals with excess visceral adipose tissue and ectopic fat.51”
From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [51]
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Overviews of Pathogen Emergence: Which Pathogens Emerge, When and Why?
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“MetS, also referred to as ‘Insulin resistance syndrome’ [4], ‘syndrome X’ [5], ‘hypertriglyceridemic waist’ [6] and ‘the deadly quartet’ [7] represents a cluster of metabolic abnormalities that heighten CVD risk [8].”
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- Authors
- Lemieux, I., Pascot, A., Couillard, C., Lamarche, B., Tchernof, A., Alméras, N., Bergeron, J., Gaudet, D., Tremblay, G., Prud’homme, D., Nadeau, A., & Després, J.-P.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- From the Quebec Heart Institute, Laval Hospital Research Center; the Lipid Research Center, CHUL Research Center; the Physical Activity Sciences Laboratory, Laval University; the Diabetes Research Unit, CHUL Research Center, Ste-Foy; and the Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Québec, Canada.
- ORCID
- Venue
- Circulation
- Published
- 2000-07-11
- Volume
- 102
- Issue
- 2
- Pages
- 179-184
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W1991251155
- Cited by
- 937
- References
- 0
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 23 · 2023: 28 · 2022: 31 · 2021: 29 · 2020: 30 · 2019: 26 · 2018: 35 · 2017: 29 · 2016: 38 · 2015: 38 · 2014: 42 · 2013: 42 · 2012: 49
- FWCI
- 18.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Heart and Stroke Foundation of Canada
- Medical Research Council Canada
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- hypertriglyceridemic waist phenotype, waist circumference, fasting plasma triglycerides, hyperinsulinemia, apolipoprotein B, small dense LDL, coronary artery disease risk, cardiovascular screening, men
- MeSH terms
- Abdomen, Adult, Apolipoproteins B, Body Composition, Coronary Artery Disease, Coronary Disease, Humans, Hyperinsulinism, Lipoproteins, LDL, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Risk Factors, Triglycerides, Hypertriglyceridemia, Biomarkers, Coronary Angiography
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