Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 Influenza a virus: Obese/Overweight Response to Influenza
Open accessAbstract
OBJECTIVE: Obese adults have a greater risk of morbidity and mortality from infection with pandemic H1N1 influenza A virus (pH1N1). The objective of the present study was to elucidate the specific mechanisms by which obesity and overweight impact the cellular immune response to pH1N1. DESIGN AND METHODS: Peripheral blood mononuclear cells from healthy weight, overweight, and obese individuals were stimulated ex vivo with live pH1N1 and then markers of activation and function were measured using flow cytometry and cytokine secretion was measured using cytometric bead array assays. RESULTS: CD4(+) and CD8(+) T cells from overweight and obese individuals expressed lower levels of CD69, CD28, CD40 ligand, and interleukin-12 receptor, as well as, produced lower levels of interferon-γ and granzyme B, compared with healthy weight individuals, suggesting deficiencies in activation and function are indicated. Dendritic cells from the three groups expressed similar levels of major histocompatibility complex-II, CD40, CD80, and CD86, as well as, produced similar levels of interleukin-12. CONCLUSIONS: The defects in CD4(+) and CD8(+) T cells may contribute to the increased morbidity and mortality from pH1N1 in obese individuals. These data also provide evidence that both overweight and obesity cause impairments in immune function.
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Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.
“Paich et al. [34] reported that overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 influenza A virus.”
From The influence of obesity on the effects of spirulina supplementation in the human metabolic response of Korean elderly (2016) · cites this paper as [34]
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- Authors
- Paich, H. A., Sheridan, P. A., Handy, J., Karlsson, E. A., Schultz-Cherry, S., Hudgens, M. G., Noah, T. L., Weir, S. S., & Beck, M. A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- St. Jude Children's Research Hospital (US)
- Department of Infectious Diseases; St. Jude Children's Research Hospital; Memphis Tennessee USA
- Corresponding author
- Beck, Melinda A.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-05-30
- Volume
- 21
- Issue
- 11
- Pages
- 2377-2386
- ISSN
- 1930-7381 (ISSN-L)
- PMC
- PMC3695020
- OpenAlex
- W1541369832
- Cited by
- 184
- References
- 26
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 15 · 2023: 16 · 2022: 18 · 2021: 31 · 2020: 23 · 2019: 15 · 2018: 6 · 2017: 12 · 2016: 10 · 2015: 11 · 2014: 10
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- The National Institutes of Health Grants NIH ROI (AI078090, P30DK056350)
- NIH NIAID (HHSN266200700005C)
- The American Lebanese Syrian Associated Charities
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- overweight, cell-mediated immunity, CD4+ T cells, CD8+ T cells, T cell activation, dendritic cells, interferon-gamma, granzyme B, IL-12, CD69, CD28, CD40 ligand, immune dysfunction
- MeSH terms
- Adult, Aged, Aged, 80 and over, Dendritic Cells, Female, Humans, Immunity, Cellular, Influenza, Human, Leukocyte Count, Lymphocyte Activation, Male, Middle Aged, Obesity, Overweight, Influenza A Virus, H1N1 Subtype, Young Adult
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