Cited by 1,150COVID-19 Clinical Research StudiesObesity, Physical Activity, DietSARS-CoV-2 and COVID-19 Research

Individuals with obesity and COVID-19: a global perspective on the epidemiology and biological relationships

Open access
Popkin, Barry M., Du, Shufa, Green, William D., Beck, Melinda A., Algaith, Taghred, Herbst, Christopher H., Alsukait, Reem F., Alluhidan, Mohammed +2 more·2020·Obesity Reviews

Abstract

Summary: The linkage of individuals with obesity and COVID‐19 is controversial and lacks systematic reviews. After a systematic search of the Chinese and English language literature on COVID‐19, 75 studies were used to conduct a series of meta‐analyses on the relationship of individuals with obesity–COVID‐19 over the full spectrum from risk to mortality. A systematic review of the mechanistic pathways for COVID‐19 and individuals with obesity is presented. Pooled analysis show individuals with obesity were more at risk for COVID‐19 positive, >46.0% higher (OR = 1.46; 95% CI, 1.30–1.65; p < 0.0001); for hospitalization, 113% higher (OR = 2.13; 95% CI, 1.74–2.60; p < 0.0001); for ICU admission, 74% higher (OR = 1.74; 95% CI, 1.46–2.08); and for mortality, 48% increase in deaths (OR = 1.48; 95% CI, 1.22–1.80; p < 0.001). Mechanistic pathways for individuals with obesity are presented in depth for factors linked with COVID‐19 risk, severity and their potential for diminished therapeutic and prophylactic treatments among these individuals. Individuals with obesity are linked with large significant increases in morbidity and mortality from COVID‐19. There are many mechanisms that jointly explain this impact. A major concern is that vaccines will be less effective for the individuals with obesity.

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  • COVID-19 caused especially high morbidity and mortality among people with comorbidities such as obesity, diabetes, kidney disease, and heart disease.

    “COVID-19 has imposed especially high morbidity and mortality burdens on people with comorbid conditions, such as obesity, diabetes, kidney disease, and heart disease.”

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Research works printed but not linked: 2

  1. [37]Antonio‐Villa NE, Bello‐Chavolla OY, Vargas‐Vazquez A, et al. Health‐care workers with COVID‐19 living in Mexico City: clinical characterization and related outcomes. medRxiv. 2020: 2020.07.02.20145169.
  2. [201]Endevelt R, IGrotto I, Sheffer R, et al. Policy and practice—regulatory measures to improve the built nutrition environment for prevention of individuals with obesity and related morbidity in Israel. Public Health Panorama. 2017; 3: 567‐ 575.

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Authors
Popkin, B. M., Du, S., Green, W. D., Beck, M. A., Algaith, T., Herbst, C. H., Alsukait, R. F., Alluhidan, M., Alazemi, N., & Shekar, M.
Affiliations
  • University of North Carolina at Chapel Hill (US)
  • Saudi Health Council (SA)
  • World Bank (US)
Corresponding author
Popkin, Barry M.
Venue
Obesity Reviews
Publisher
Wiley
Published
2020-08-26
Volume
21
Issue
11
Pages
e13128-e13128
ISSN
  • 1467-7881 (ISSN-L)
  • 1467-789X
OpenAlex
W3080296106
Cited by
1,150
References
227
Citations by year
2026: 39 · 2025: 72 · 2024: 106 · 2023: 191 · 2022: 277 · 2021: 401 · 2020: 62 · 2012: 1
FWCI
11.01
Type
journal article
Language
en
Update notices
erratum (2021-08-03)
Open access
Locations
  • Obesity Reviews (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
World Bank Group
Topics
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
obesity, COVID-19 pandemic, SARS-CoV-2, COVID-19 risk, hospitalization, intensive care unit admission, mortality, disease severity, mechanistic pathways, vaccine effectiveness, comorbidities
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Humans, Obesity, Pneumonia, Viral, Comorbidity, Coronavirus Infections, Internationality, Pandemics

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