Improving diabetes outcomes through lifestyle change—a randomized controlled trial
Open accessAbstract
Objective: To compare a diabetes group lifestyle intervention (GLI) with dietitian referral for medical nutrition therapy (RD) for weight loss in the usual care setting. Methods: Randomized clinical trial was conducted with 57 primary care patients with type 2 diabetes and body mass index (BMI) >25 kg/m 2 who received either a dietitian‐led 19‐week GLI adapted from the Look AHEAD study or RD. Outcome measures include 6‐month and 1‐year weight loss, changes in medications, glycemic control, cardiac risk factors, and cost analysis. Results: Patients were mean age 61, 59% male, and 32% non‐white, and they weighed 97 kg with mean HbA1c 8.2%. At 6 months, 46% of GLI vs. 21% of RD lost ≥5% body weight ( P = 0.04), with mean weight loss 6.6 (SD 7.0) kg with GLI and 2.1 (3.5) kg in RD ( P = 0.004). HbA1c improved by 0.70 (1.13) vs. 0.39 (1.51) in GLI vs. RD ( P = 0.4), respectively, and 82% vs. 38% stopped or reduced diabetes medications ( P < 0.001). Weight loss remained significantly greater in GLI compared to RD at 1 year. GLI program cost was $578 per participant. Conclusions: An affordable GLI achieved significantly more weight loss and medication reduction than RD in primary care patients with type 2 diabetes.
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- Authors
- Delahanty, L. M., Dalton, K. M., Porneala, B., Chang, Y., Goldman, V. M., Levy, D., Nathan, D. M., & Wexler, D. J.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Delahanty, Linda M.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2015-08-11
- Volume
- 23
- Issue
- 9
- Pages
- 1792-1799
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W1556374185
- Cited by
- 55
- References
- 18
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 12 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 1
- FWCI
- 4.91
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts General Hospital
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, medical nutrition therapy, dietitian referral, weight loss, glycemic control, HbA1c, diabetes medication reduction, cardiovascular risk factors, primary care, lookahead, cost analysis
- MeSH terms
- Aged, Attitude to Health, Blood Glucose, Diabetes Mellitus, Type 2, Female, Humans, Life Style, Male, Middle Aged, Risk Factors, Weight Loss, Health Behavior, Body Mass Index, Treatment Outcome
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