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Functional structure and composition of the extracellular matrix

Bosman, Fred T, Stamenkovic, Ivan·2003·The Journal of Pathology

Abstract

In this brief introductory paper the general structure and the molecular composition of the extracellular matrix are outlined. Ultrastructural morphology of the extracellular matrix is introduced and subsequently the molecular structure of each of the main protein families, which together make up the extracellular matrix, is reviewed. Collagens, laminins, tenascins, and proteoglycans are addressed. An important common feature is the domain structure of these in general very large proteins. Several families have domains in common, which favours extensive interactions. Integrins play an important role in these interactions and also in the communication between cells and the matrix. The extracellular matrix appears to be a very dynamic structure, which has a prominent role in normal development as well as in a variety of disease processes. Matrix metalloproteinases are essential actors in this complex interplay between cells and the extracellular matrix. Copyright © 2003 John Wiley & Sons, Ltd.

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Metadata

Authors
Bosman, F. T., & Stamenkovic, I.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2003-07
Volume
200
Issue
4
Pages
423-428
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
OpenAlex
W2053497293
Cited by
821
References
4
FWCI
9.27
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Functional structure and composition of the extracellular matrix. https://app.cochat.ai/papers/10.1002/path.1437
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Bosman, F. T., & Stamenkovic, I. (2003). Functional structure and composition of the extracellular matrix. The Journal of Pathology. https://doi.org/10.1002/path.1437

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.