The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
BCL‐2 expression in adult and embryonic non‐haematopoietic tissues
Abstract
The B‐cell leukaemia/lymphoma‐2 (bcl‐2) proto‐oncogene is unusual as its product appears to provide survival advantage to B cells by blocking apoptosis. In this study, the expression of bcl‐2 has been examined in normal nonhaematopoietic tissues, embryos, and psoriatic skin by immunohistochemical staining. Bcl‐2 protein expression is mainly observed in cell populations with a long life and/or proliferating ability such as duct cells in exocrine glands, basal keratinocytes, cells at the bottom of colon crypts, and neurons. In the skin of both adult and embryo and also embryonic kidney and cartilage, bcl‐2 expression was observed in cells which were undergoing morphological transition from undifferentiated stem cells to committed precursor cells. The finding of bcl‐2 expression in the terminal differentiated syncytial trophoblast, but not cytotrophoblast, and in some cells responsive to hormone stimulation such as in the endometrium and myometrium suggests that the gene expression may be related too hormone responsiveness. As no bci‐2 localization was seen in the benign hyperproliferative skin condition psoriasis, this does not suggest a straightforward link to proliferation. These observations support the view that the bcl‐2 gene may have an important role in cell development, maturation, and the path to terminal differentiation.
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Cites
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
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Self-citationBcl-2: B Cell Life, Death and Neoplasia
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Cited by
Bcl-2 and the regulation of programmed cell death
Reed, J. (1994) · The Journal of cell biology · doi:10.1083/jcb.124.1.1 · Cited by 2,305
Sex steroidal regulation of uterine leiomyoma growth and apoptosis
Maruo, T. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh019 · Cited by 294
bcl-2: Role in epithelial differentiation and oncogenesis
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Self-citationUckan, D. (1997) · Molecular Human Reproduction · doi:10.1093/molehr/3.8.655 · Cited by 206
Simpson, J. L., Bischoff, F. Z., Kamat, A., Buster, J. E., & Carson, S. A. (2003) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(02)00051-7 · Cited by 83
Metadata
- Authors
- Lu, Q., Poulsom, R., Wong, L., & Hanby, A. M.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 1993-04
- Volume
- 169
- Issue
- 4
- Pages
- 431-437
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2022273331
- Cited by
- 261
- References
- 13
- FWCI
- 11.87
- Type
- journal article
- Language
- en
- Open access
- closed
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