Cited by 83Endometriosis Research and TreatmentGenetic Associations and EpidemiologyEctopic Pregnancy Diagnosis and Management

Genetics of endometriosis

Simpson, Joe Leigh, Bischoff, Farideh Z, Kamat, Aparna, Buster, John E, Carson, Sandra A·2003·Obstetrics and Gynecology Clinics of North America

Abstract

Endometriosis long has been recognized as showing heritable tendencies, with recurrence risks of 5% to 7% for first-degree relatives. The risk indicates that polygenic and multifactorial etiology is far more likely to be the cause than mendelian inheritance. The current task is to determine the number and location of genes responsible for endometriosis. Molecular advances of the past decade make identification and elucidation of these genes a reality. The authors review the basis for concluding that endometriosis is a genetic disorder of polygenic/multifactorial inheritance. Genome-wide strategies for identifying causative genes are considered and available data on association or linkage to putative candidate genes systematically reviewed.

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Crossref · 10.1016/s0889-8545(02)00051-7

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Authors
Simpson, J. L., Bischoff, F. Z., Kamat, A., Buster, J. E., & Carson, S. A.
Affiliations
Baylor College of Medicine (US)
Corresponding author
Simpson, Joe Leigh
Venue
Obstetrics and Gynecology Clinics of North America
Publisher
Elsevier BV
Published
2003-03
Volume
30
Issue
1
Pages
21-40
ISSN
0889-8545 (ISSN-L)
OpenAlex
W2059455531
Cited by
83
References
87
Citations by year
2025: 1 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 6 · 2012: 11
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Locations
  • Obstetrics and Gynecology Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords
endometriosis, genetic susceptibility, polygenic inheritance, multifactorial etiology, familial recurrence risk, candidate genes, genetic linkage, genome-wide association study, causal genes
MeSH terms
Endometriosis, Female, Genes, Genetic Techniques, Humans

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