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Cited by 308

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

The endocrine system and ageing

Chahal, HS, Drake, WM·2007·The Journal of Pathology
DOI 10.1002/path.2110
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Abstract

Complex changes occur within the endocrine system of ageing individuals. This article explores the changes that occur in the metabolism and production of various hormones and discusses the resulting clinical consequences. As individuals age there is a decline in the peripheral levels of oestrogen and testosterone, with an increase in luteinizing hormone, follicle‐stimulating hormone and sex hormone‐binding globulin. Additionally there is a decline in serum concentrations of growth hormone, insulin‐like growth factor‐I and dehydroepiandrosterone and its sulphate‐bound form. Even though there are complex changes within the hypothalmo–pituitary–adrenal/thyroid axis, there is minimal change in adrenal and thyroid function with ageing. The clinical significance of these deficiencies with age are variable and include reduced protein synthesis, decrease in lean body mass and bone mass, increased fat mass, insulin resistance, higher cardiovascular disease risk, increase in vasomotor symptoms, fatigue, depression, anaemia, poor libido, erectile deficiency and a decline in immune function. For each endocrine system, studies have been carried out in an attempt to reverse the effects of ageing by altering the serum hormonal levels of older individuals. However, the real benefits of hormonal treatment in older individuals are still being evaluated. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Metadata

Authors
Chahal, H., & Drake, W.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2007-01
Volume
211
Issue
2
Pages
173-180
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.2110
OpenAlex
W2136023057
Cited by
308
References
14
FWCI
12.44
Type
journal article
Language
en
Open access
closed

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.