The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cancer cell invasion and EMT marker expression: a three‐dimensional study of the human cancer–host interface
Abstract
Cancer cell invasion takes place at the cancer–host interface and is a prerequisite for distant metastasis. The relationships between current biological and clinical concepts such as cell migration modes, tumour budding and epithelial–mesenchymal transition (EMT) remains unclear in several aspects, especially for the 'real' situation in human cancer. We developed a novel method that provides exact three‐dimensional (3D) information on both microscopic morphology and gene expression, over a virtually unlimited spatial range, by reconstruction from serial immunostained tissue slices. Quantitative 3D assessment of tumour budding at the cancer–host interface in human pancreatic, colorectal, lung and breast adenocarcinoma suggests collective cell migration as the mechanism of cancer cell invasion, while single cancer cell migration seems to be virtually absent. Budding tumour cells display a shift towards spindle‐like as well as a rounded morphology. This is associated with decreased E‐cadherin staining intensity and a shift from membranous to cytoplasmic staining, as well as increased nuclear ZEB1 expression. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The basics of epithelial-mesenchymal transition
Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196
Cited by
Non-redundant functions of EMT transcription factors
Stemmler, M. P., Eccles, R. L., Brabletz, S., & Brabletz, T. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0196-y · Cited by 524
Self-citationControversies around epithelial–mesenchymal plasticity in cancer metastasis
Williams, E. D., Gao, D., Redfern, A., & Thompson, E. W. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0213-x · Cited by 451
Gonzalez-Avila, G., Sommer, B., Mendoza-Posada, D. A., Ramos, C., Garcia-Hernandez, A. A., & Falfan-Valencia, R. (2019) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2019.02.010 · Cited by 373
EMT and MET : necessary or permissive for metastasis?
Jolly, M. K., Ware, K. E., Gilja, S., Somarelli, J. A., & Levine, H. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12083 · Cited by 371
Tuning Collective Cell Migration by Cell–Cell Junction Regulation
Friedl, P., & Mayor, R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a029199 · Cited by 357
Towards targeting of shared mechanisms of cancer metastasis and therapy resistance
Weiss, F., Lauffenburger, D., & Friedl, P. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-021-00427-0 · Cited by 293
The Cell Biology of Metastatic Invasion in Pancreatic Cancer: Updates and Mechanistic Insights
Joshi, V. B., Gutierrez Ruiz, O. L., & Razidlo, G. L. (2023) · Cancers · doi:10.3390/cancers15072169 · Cited by 32
Metadata
- Authors
- Bronsert, P., Enderle‐Ammour, K., Bader, M., Timme, S., Kuehs, M., Csanadi, A., Kayser, G., Kohler, I., Bausch, D., Hoeppner, J., Hopt, U., Keck, T., Stickeler, E., Passlick, B., Schilling, O., Reiss, C., Vashist, Y., Brabletz, T., Berger, J., Lotz, J., Olesch, J., Werner, M., & Wellner, U.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2014-10-10
- Volume
- 234
- Issue
- 3
- Pages
- 410-422
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2120981549
- Cited by
- 341
- References
- 1
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
