The DOI matches its Crossref record; 293 of the 293 references it cites were found in a registry or an index.
Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer
Open accessAbstract
Matrix metalloproteinases (MMPs) participate from the initial phases of cancer onset to the settlement of a metastatic niche in a second organ. Their role in cancer progression is related to their involvement in the extracellular matrix (ECM) degradation and in the regulation and processing of adhesion and cytoskeletal proteins, growth factors, chemokines and cytokines. MMPs participation in cancer progression makes them an attractive target for cancer therapy. MMPs have also been used for theranostic purposes in the detection of primary tumor and metastatic tissue in which a particular MMP is overexpressed, to follow up on therapy responses, and in the activation of cancer cytotoxic pro-drugs as part of nano-delivery-systems that increase drug concentration in a specific tumor target. Herein, we review MMPs molecular characteristics, their synthesis regulation and enzymatic activity, their participation in the metastatic process, and how their functions have been used to improve cancer treatment.
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3 retracted
Andreuzzi, E., Colladel, R., Pellicani, R., Tarticchio, G., Cannizzaro, R., Spessotto, P., Bussolati, B., Brossa, A., Paoli, P. D., Canzonieri, V., et al. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.04.002 · Cited by 83
RetractedSpinella, F., Caprara, V., Garrafa, E., Castro, V. D., Rosanò, L., Natali, P. G., & Bagnato, A. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y10-050 · Cited by 24
RetractedMMP-13 is involved in oral cancer cell metastasis
Huang, S.-H., Law, C., Kuo, P.-H., Hu, R., Yang, C.-C., Chung, T.-W., Li, J.-M., Lin, L., Liu, Y., Liao, E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7942 · Cited by 24
RetractedMolecular mechanisms and clinical applications of angiogenesis
Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151
Tumor Metastasis: Molecular Insights and Evolving Paradigms
Valastyan, S., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.09.024 · Cited by 4,011
Greaves, M., & Maley, C. C. (2012) · Nature · doi:10.1038/nature10762 · Cited by 3,162
The extracellular matrix: A dynamic niche in cancer progression
Lu, P., Weaver, V. M., & Werb, Z. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201102147 · Cited by 3,024
Matrix metalloproteinases and tumor metastasis
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A tense situation: forcing tumour progression
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Cited by
Bertocchi, A., Carloni, S., Ravenda, P. S., Bertalot, G., Spadoni, I., Lo Cascio, A., Gandini, S., Lizier, M., Braga, D., Asnicar, F., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.004 · Cited by 515
Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression
Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 503
Datta, A., Deng, S., Gopal, V., Yap, K. C.-H., Halim, C. E., Lye, M. L., Ong, M. S., Tan, T. Z., Sethi, G., Hooi, S. C., et al. (2021) · Cancers · doi:10.3390/cancers13081882 · Cited by 184
Toczek, J., Gona, K., Liu, Y., Ahmad, A., Ghim, M., Ojha, D., Kukreja, G., Salarian, M., Luehmann, H., Heo, G. S., et al. (2023) · Circulation: Cardiovascular Imaging · doi:10.1161/circimaging.122.014615 · Cited by 12
Metadata
- Authors
- Gonzalez-Avila, G., Sommer, B., Mendoza-Posada, D. A., Ramos, C., Garcia-Hernandez, A. A., & Falfan-Valencia, R.
- Venue
- Critical Reviews in Oncology/Hematology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 137
- Pages
- 57-83
- ISSN
- 1040-8428 (ISSN-L)
- OpenAlex
- W2919016311
- Cited by
- 373
- References
- 293
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Gonzalez-Avila, G., Sommer, B., Mendoza-Posada, D. A., Ramos, C., Garcia-Hernandez, A. A., & Falfan-Valencia, R. (2019). Matrix metalloproteinases participation in the metastatic process and their diagnostic and therapeutic applications in cancer. Critical Reviews in Oncology/Hematology. https://doi.org/10.1016/j.critrevonc.2019.02.010
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
