Non-redundant functions of EMT transcription factors

An integrated encyclopedia of DNA elements in the human genome

The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072 · see citing works

Molecular mechanisms of epithelial–mesenchymal transition

Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091 · see citing works

EMT: 2016

Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492 · see citing works

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121 · see citing works

Collective cell migration in morphogenesis, regeneration and cancer

Friedl, P., & Gilmour, D. T. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2720 · Cited by 2,668 · see citing works

EMT and Dissemination Precede Pancreatic Tumor Formation

Rhim, A. D., Mirek, E. T., Aiello, N. M., Maitra, A., Bailey, J. M., McAllister, F., Reichert, M., Beatty, G. L., Rustgi, A. K., Vonderheide, R. H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.025 · Cited by 2,136 · see citing works

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

Zheng, X., Carstens, J. L., Kim, J., Scheible, M., Kaye, J. A., Sugimoto, H., Wu, C.-C., LeBleu, V. S., & Kalluri, R. (2015) · Nature · doi:10.1038/nature16064 · Cited by 2,018 · see citing works

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Viswanathan, V. S., Ryan, M. J., Dhruv, H. D., Gill, S., Eichhoff, O. M., Seashore-Ludlow, B., Kaffenberger, S. D., Eaton, J. K., Shimada, K., Aguirre, A. J., et al. (2017) · Nature · doi:10.1038/nature23007 · Cited by 2,011 · see citing works

EMT in cancer

Brabletz, T., Kalluri, R., Nieto, M. A., & Weinberg, R. A. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.118 · Cited by 1,961 · see citing works

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., et al. (2015) · Nature · doi:10.1038/nature15748 · Cited by 1,791 · see citing works

The snail superfamily of zinc-finger transcription factors

Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719 · see citing works

Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition

Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., & Hung, M.-C. (2004) · Nature Cell Biology · doi:10.1038/ncb1173 · Cited by 1,581 · see citing works

Identification of the tumour transition states occurring during EMT

Pastushenko, I., Brisebarre, A., Sifrim, A., Fioramonti, M., Revenco, T., Boumahdi, S., Keymeulen, A. V., Brown, D. V., Moers, V., Lemaire, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0040-3 · Cited by 1,488 · see citing works

Migrating cancer stem cells — an integrated concept of malignant tumour progression

Brabletz, T., Jung, A., Spaderna, S., Hlubek, F., & Kirchner, T. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1694 · Cited by 1,355 · see citing works

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S., & Yang, J. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.022 · Cited by 1,073 · see citing works

Oncogenic roles of EMT-inducing transcription factors

Puisieux, A., Brabletz, T., & Caramel, J. (2014) · Nature Cell Biology · doi:10.1038/ncb2976 · Cited by 1,032 · see citing works

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

Krebs, A. M., Mitschke, J., Losada, M. L., Schmalhofer, O., Boerries, M., Busch, H. S., Böttcher, M., Mougiakakos, D., Reichardt, W., Bronsert, P., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3513 · Cited by 979 · see citing works

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

Ocaña, O. H., Córcoles, R. C., Fabra, À., Moreno‐Bueno, G., Acloque, H., Vega, S., Barrallo‐Gimeno, A., Cano, A., & Nieto, M. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.012 · Cited by 973 · see citing works

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Chen, L., Gibbons, D. L., Goswami, S., Cortez, M. A., Ahn, Y., Byers, L. A., Zhang, X., Yi, X., Dwyer, D. W., Lin, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6241 · Cited by 972 · see citing works

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

Singh, A., Greninger, P., Rhodes, D., Koopman, L., Violette, S., Bardeesy, N., & Settleman, J. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.03.022 · Cited by 841 · see citing works

Epithelial‐mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

Tan, T. Z., Miow, Q. H., Miki, Y., Noda, T., Mori, S., Huang, R. Y., & Thiery, J. P. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404208 · Cited by 792 · see citing works

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

Ye, X., Tam, W. L., Shibue, T., Kaygusuz, Y., Reinhardt, F., Eaton, E. N., & Weinberg, R. A. (2015) · Nature · doi:10.1038/nature14897 · Cited by 697 · see citing works

The Mouse Snail Gene Encodes a Key Regulator of the Epithelial-Mesenchymal Transition

Carver, E. A., Jiang, R., Lan, Y., Oram, K. F., & Gridley, T. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.23.8184-8188.2001 · Cited by 624 · see citing works

To differentiate or not — routes towards metastasis

Brabletz, T. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3265 · Cited by 622 · see citing works

twist is required in head mesenchyme for cranial neural tube morphogenesis.Preprint

Chen, Z., & Behringer, R. R. (1995) · Genes & Development · doi:10.1101/gad.9.6.686 · Cited by 616 · see citing works

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

Blanco, M. J., Moreno‐Bueno, G., Sarrió, D., Locascio, A., Cano, A., Palacios, J., & Nieto, M. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205416 · Cited by 576 · see citing works

Mesenchyme Forkhead 1 ( FOXC2 ) plays a key role in metastasis and is associated with aggressive basal-like breast cancers

Mani, S. A., Yang, J., Brooks, M. W., Schwaninger, G., Zhou, A. Y., Miura, N., Kutok, J. L., Hartwell, K. A., Richardson, A. L., & Weinberg, R. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703900104 · Cited by 576 · see citing works

The Fallacy of Epithelial Mesenchymal Transition in Neoplasia

Jackson, D. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0699 · Cited by 531 · see citing works

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

Caramel, J., Papadogeorgakis, E., Hill, L., Browne, G. J., Richard, G., Wierinckx, A., Saldanha, G. S., Osborne, J. E., Hutchinson, P. J., Tse, G., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.08.018 · Cited by 516 · see citing works

Snail Induction of Epithelial to Mesenchymal Transition in Tumor Cells Is Accompanied by MUC1 Repression andZEB1 Expression

Guaita, S., Puig, I., Francı́, C., Garrido, M., Dominguez-Sola, D., Batlle, E., Sancho, E., Dedhar, S., de Herreros, A. G., & Baulida, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206400200 · Cited by 501 · see citing works

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

Wang, S.-P., Wang, W.-L., Chang, Y.-L., Wu, C.-T., Chao, Y.-C., Kao, S.-H., Yuan, A., Lin, C.-W., Yang, S.-C., Chan, W.-K., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1875 · Cited by 493 · see citing works

Sox4 Is a Master Regulator of Epithelial-Mesenchymal Transition by Controlling Ezh2 Expression and Epigenetic Reprogramming

Tiwari, N., Tiwari, V. K., Waldmeier, L., Balwierz, P. J., Arnold, P., Pachkov, M. V., Meyer‐Schaller, N., Schübeler, D., van Nimwegen, E., & Christofori, G. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.04.020 · Cited by 480 · see citing works

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

Eckert, M. A., Lwin, T. M., Chang, A. T., Kim, J., Danis, E. P., Lucila Ohno-machado, A., & Yang, J. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.036 · Cited by 476 · see citing works

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

Zhang, P., Wei, Y., Wang, L., Debeb, B. G., Yuan, Y., Zhang, J., Yuan, J., Wang, M., Chen, D., Sun, Y., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3013 · Cited by 454 · see citing works

A New Role for E12/E47 in the Repression ofE-cadherin Expression and Epithelial-Mesenchymal Transitions

Pérez‐Moreno, M., Locascio, A., Rodrigo, I., Dhondt, G., Portillo, F., Nieto, M. A., & Cano, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100827200 · Cited by 440 · see citing works

Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins

Postigo, A. A., Depp, J. L., Taylor, J. J., & Kroll, K. L. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg226 · Cited by 388 · see citing works

Transcription Factor Binding in Human Cells Occurs in Dense Clusters Formed around Cohesin Anchor Sites

Yan, J., Enge, M., Whitington, T., Dave, K., Liu, J., Sur, I., Schmierer, B., Jolma, A., Kivioja, T., Taipale, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.07.034 · Cited by 376 · see citing works

Distinct Properties of Cell-Type-Specific and Shared Transcription Factor Binding Sites

Gertz, J., Savic, D., Varley, K. E., Partridge, E. C., Safi, A., Jain, P., Cooper, G. M., Reddy, T. E., Crawford, G. E., & Myers, R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.037 · Cited by 363 · see citing works

Transcription factor binding dynamics during human ES cell differentiation

Tsankov, A. M., Gu, H., Akopian, V., Ziller, M. J., Donaghey, J., Amit, I., Gnirke, A., & Meissner, A. (2015) · Nature · doi:10.1038/nature14233 · Cited by 349 · see citing works

Cancer cell invasion and EMT marker expression: a three‐dimensional study of the human cancer–host interface

Bronsert, P., Enderle-Ammour, K., Bader, M., Timme, S., Kuehs, M., Csanádi, Á., Kayser, G., Kohler, I., Bausch, D., Hoeppner, J., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4416 · Cited by 341 · see citing works

Induction of epithelial–mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent

Davis, F. M., Azimi, I., Faville, R., Peters, A. A., Jalink, K., Putney, J. W., Goodhill, G. J., Thompson, E. W., Roberts‐Thomson, S. J., & Monteith, G. R. (2013) · Oncogene · doi:10.1038/onc.2013.187 · Cited by 333 · see citing works

Upholding a role for EMT in breast cancer metastasis

Ye, X., Brabletz, T., Kang, Y., Longmore, G. D., Nieto, M. A., Stanger, B. Z., Yang, J., & Weinberg, R. A. (2017) · Nature · doi:10.1038/nature22816 · Cited by 333 · see citing works

Functional Cooperation between Snail1 and Twist in the Regulation of ZEB1 Expression during Epithelial to Mesenchymal Transition

Dave, N., Guaita‐Esteruelas, S., Gutarra, S., Frías, A., Beltran-Nebot, M., Peiró, S., & de Herreros, A. G. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.168625 · Cited by 332 · see citing works

Metabolic reprogramming and epithelial‐to‐mesenchymal transition in cancer

Sciacovelli, M., & Frezza, C. (2017) · FEBS Journal · doi:10.1111/febs.14090 · Cited by 324 · see citing works

Genetic Profiling of Epithelial Cells Expressing E-Cadherin Repressors Reveals a Distinct Role for Snail, Slug, and E47 Factors in Epithelial-Mesenchymal Transition

Moreno‐Bueno, G., Cubillo, E., Sarrió, D., Peinado, H., Rodríguez-Pinilla, S. M., Villa, S., Bolós, V., Jordà, M., Fabra, À., Portillo, F., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0479 · Cited by 320 · see citing works

The EMT regulator slug and lung carcinogenesis

Shih, J.-Y., & Yang, P. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr110 · Cited by 315 · see citing works

Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo

Sefton, M., Sánchez, S., & Nieto, M. A. (1998) · Development · doi:10.1242/dev.125.16.3111 · Cited by 315 · see citing works

Mice Lacking Zfhx1b, the Gene That Codes for Smad-Interacting Protein-1, Reveal a Role for Multiple Neural Crest Cell Defects in the Etiology of Hirschsprung Disease–Mental Retardation Syndrome

de Putte, T. V., Maruhashi, M., Francis, A., Nelles, L., Kondoh, H., Huylebroeck, D., & Higashi, Y. (2003) · The American Journal of Human Genetics · doi:10.1086/346092 · Cited by 309 · see citing works

Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition

Xiong, H., Hong, J., Du, W., Lin, Y., Ren, L., Wang, Y., Su, W., Wang, J., Cui, Y., Wang, Z., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.295964 · Cited by 308 · see citing works

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

Lehmann, W., Mossmann, D., Kleemann, J., Mock, K., Meisinger, C., Brummer, T., Herr, R., Brabletz, S., Stemmler, M. P., & Brabletz, T. (2016) · Nature Communications · doi:10.1038/ncomms10498 · Cited by 305 · see citing works

Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis

Joseph, J. V., Conroy, S., Pavlov, K., Sontakke, P., Tomar, T., Eggens‐Meijer, E., Balasubramaniyan, V., Wagemakers, M., den Dunnen, W. F. A., & Kruyt, F. A. E. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.01.010 · Cited by 301 · see citing works

δEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages

Takagi, T., Moribe, H., Kondoh, H., & Higashi, Y. (1998) · Development · doi:10.1242/dev.125.1.21 · Cited by 296 · see citing works

Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway

Postigo, A. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg225 · Cited by 295 · see citing works

EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET

Goossens, S., Vandamme, N., Vlierberghe, P. V., & Berx, G. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.06.006 · Cited by 292 · see citing works

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

Shin, S., Dimitri, C. A., Yoon, S.-O., Dowdle, W. E., & Blenis, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.020 · Cited by 291 · see citing works

Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

Alsuliman, A., Çolak, D., Al‐Harazi, O., Fitwi, H., Tulbah, A. M., Al‐Tweigeri, T., Al-Alwan, M. M., & Ghebeh, H. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0421-2 · Cited by 288 · see citing works

New mode of DNA binding of multi‐zinc finger transcription factors: δEF1 family members bind with two hands to two target sites

Remacle, J., Kraft, H., Lerchner, W., Wuytens, G., Collart, C., Verschueren, K., Smith, J. C., & Huylebroeck, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5073 · Cited by 276 · see citing works

Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity

Skrypek, N., Goossens, S., Smedt, E. D., Vandamme, N., & Berx, G. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.08.004 · Cited by 270 · see citing works

The epithelial–mesenchymal transition under control: Global programs to regulate epithelial plasticity

Nieto, M. A., & Cano, A. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2012.05.003 · Cited by 263 · see citing works

Upholding a role for EMT in pancreatic cancer metastasis

Aiello, N. M., Brabletz, T., Kang, Y., Nieto, M. A., Weinberg, R. A., & Stanger, B. Z. (2017) · Nature · doi:10.1038/nature22963 · Cited by 260 · see citing works

Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3

Robichaud, N., Rincon, S. V. D., Huor, B., Alain, T., Petruccelli, L. A., Hearnden, J., Gonçalves, C., Grotegut, S., Spruck, C., Furic, L., et al. (2014) · Oncogene · doi:10.1038/onc.2014.146 · Cited by 259 · see citing works

EMT : Present and future in clinical oncology

Santamarı́a, P. G., Moreno‐Bueno, G., Portillo, F., & Cano, A. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12091 · Cited by 259 · see citing works

Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs

Lamouille, S., Subramanyam, D., Blelloch, R. H., & Derynck, R. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.01.008 · Cited by 257 · see citing works

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Schönhuber, N., Seidler, B., Schuck, K., Veltkamp, C., Schachtler, C., Zukowska, M., Eser, S., Feyerabend, T. B., Paul, M. C., Eser, P., et al. (2014) · Nature Medicine · doi:10.1038/nm.3646 · Cited by 238 · see citing works

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

Tran, H. D., Luitel, K., Kim, M., Zhang, K., Longmore, G. D., & Tran, D. D. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0923 · Cited by 234 · see citing works

Twist Function Is Required for the Morphogenesis of the Cephalic Neural Tube and the Differentiation of the Cranial Neural Crest Cells in the Mouse Embryo

Soo, K., O'Rourke, M. P., Khoo, P., Steiner, K. A., Wong, N., Behringer, R. R., & Tam, P. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0699 · Cited by 228 · see citing works

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

van den Beucken, T., Koch, E., Chu, K., Rupaimoole, R., Prickaerts, P., Adriaens, M. E., Voncken, J. W., Harris, A. L., Buffa, F. M., Haider, S. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6203 · Cited by 226 · see citing works

Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8–Akt–Slug pathway

Visciano, C., Liotti, F., Prevete, N., Calı̀, G., Franco, R., Collina, F., de Paulis, A., Marone, G., Santoro, M. M., & Melillo, R. M. (2015) · Oncogene · doi:10.1038/onc.2014.441 · Cited by 214 · see citing works

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

Morel, A., Hinkal, G. W., Thomas, C., Fauvet, F., Courtois-Cox, S., Wierinckx, A., Devouassoux‐Shisheboran, M., Treilleux, I., Tissier, A., Gras, B., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002723 · Cited by 207 · see citing works

Direct Repression of Cyclin D1 by SIP1 Attenuates Cell Cycle Progression in Cells Undergoing an Epithelial Mesenchymal Transition

Mejlvang, J., Kriajevska, M. V., Vandewalle, C., Chernova, T., Sayan, E., Berx, G., Mellon, J. K., & Tulchinsky, E. M. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-05-0406 · Cited by 206 · see citing works

Cell plasticity in epithelial homeostasis and tumorigenesis

Varga, J., & Greten, F. R. (2017) · Nature Cell Biology · doi:10.1038/ncb3611 · Cited by 204 · see citing works

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression

Denecker, G., Vandamme, N., Akay, Ö., Koludrović, D., Taminau, J., Lemeire, K., Gheldof, A., Craene, B. D., Gele, M. V., Brochez, L., et al. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.44 · Cited by 203 · see citing works

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

Natsuizaka, M., Whelan, K. A., Kagawa, S., Tanaka, K., Giroux, V., Chandramouleeswaran, P. M., Long, A., Sahu, V., Darling, D. S., Que, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01500-9 · Cited by 203 · see citing works

Different Levels of Twist1 Regulate Skin Tumor Initiation, Stemness, and Progression

Beck, B., Lapouge, G., Rorive, S., Drogat, B., Desaedelaere, K., Delafaille, S., Dubois, C., Salmon, I. J., Willekens, K., Marine, J., et al. (2015) · Cell stem cell · doi:10.1016/j.stem.2014.12.002 · Cited by 201 · see citing works

Temporal and Spatial Cooperation of Snail1 and Twist1 during Epithelial–Mesenchymal Transition Predicts for Human Breast Cancer Recurrence

Tran, D. D., Corsa, C. A. S., Biswas, H., Aft, R., & Longmore, G. D. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-11-0371 · Cited by 197 · see citing works

Epithelial–Mesenchymal Transition and Tumor Suppression Are Controlled by a Reciprocal Feedback Loop between ZEB1 and Grainyhead-like-2

Cieply, B. W., Farris, J. C., Denvir, J., Ford, H. L., & Frisch, S. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4082 · Cited by 193 · see citing works

Multiparameter functional diversity of human C2H2 zinc finger proteins

Schmitges, F. W., Radovani, E., Najafabadi, H. S., Barazandeh, M., Campitelli, L. F., Yin, Y., Jolma, A., Zhong, G., Guo, H., Kanagalingam, T., et al. (2016) · Genome Research · doi:10.1101/gr.209643.116 · Cited by 193 · see citing works

The relevance of EMT in breast cancer metastasis: Correlation or causality?

Bill, R., & Christofori, G. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.05.002 · Cited by 192 · see citing works

SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer

Sayan, E., Griffiths, T. R. L., Pal, R. P., Browne, G. J., Ruddick, A., Yağcı, T., Edwards, R., Mayer, N. J., Qazi, H. A. R., Goyal, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902042106 · Cited by 192 · see citing works

Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis

Low-Marchelli, J. M., Ardi, V. C., Vizcarra, E. A., van Rooijen, N., Quigley, J. P., & Yang, J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-0653 · Cited by 191 · see citing works

Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis

Escrivà, M., Peiró, S., Herranz, N., Villagrasa, P., Dave, N., Montserrat-Sentís, B., Murray, S. A., Francı́, C., Gridley, T., Virtanen, I., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02061-07 · Cited by 190 · see citing works

A stemness-related ZEB1–MSRB3 axis governs cellular pliancy and breast cancer genome stability

Morel, A., Ginestier, C., Pommier, R. M., Cabaud, O., Ruiz, E. M., Wicinski, J., Devouassoux‐Shisheboran, M., Combaret, V., Finetti, P., Chassot, C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4323 · Cited by 179 · see citing works

Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

Gheldof, A., Hulpiau, P., Roy, F. M. V., Craene, B. D., & Berx, G. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0935-3 · Cited by 177 · see citing works

Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation

Schmidt, J. M., Panzilius, E., Bartsch, H. S., Irmler, M., Beckers, J., Kari, V., Linnemann, J. R., Drăgoi, D., Hirschi, B., Kloos, U. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.032 · Cited by 172 · see citing works

Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing

Arnoux, V., Nassour, M., L’Helgoualc’h, A., Hipskind, R. A., & Savagner, P. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1078 · Cited by 172 · see citing works

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

Ahn, Y., Gibbons, D. L., Chakravarti, D., Creighton, C. J., Rizvi, Z. H., Adams, H. P., Pertsemlidis, A., Gregory, P. A., Wright, J. A., Goodall, G. J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63608 · Cited by 157 · see citing works

Differential Role of Snail1 and Snail2 Zinc Fingers in E-cadherin Repression and Epithelial to Mesenchymal Transition

Villarejo, A., Cortés-Cabrera, Á., Molina-Ortíz, P., Portillo, F., & Cano, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.528026 · Cited by 154 · see citing works

Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells

Kogan-Sakin, I., Tabach, Y., Buganim, Y., Molchadsky, A., Solomon, H., Madar, S., Kamer, I., Stambolsky, P., Shelly, A., Goldfinger, N., et al. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.94 · Cited by 153 · see citing works

Oscillations of the Snail Genes in the Presomitic Mesoderm Coordinate Segmental Patterning and Morphogenesis in Vertebrate Somitogenesis

Dale, J. K., Malapert, P., Chal, J., Vilhais-Neto, G. C., Maroto, M., Johnson, T., Jayasinghe, S. M., Trainor, P. A., Herrmann, B. G., & Pourquié, O. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.011 · Cited by 151 · see citing works

Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin

Long, J., Zuo, D., & Park, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504477200 · Cited by 151 · see citing works

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1

Wang, Y., Bu, F., Royer, C., Serres, S., Larkin, J. R., Soto, M. S., Sibson, N. R., Salter, V., Fritzsche, F. R., Turnquist, C., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3050 · Cited by 146 · see citing works

Dissection of transcriptional and cis‐regulatory control of differentiation in human pancreatic cancer

Diaferia, G. R., Balestrieri, C., Prosperini, E., Nicoli, P., Spaggiari, P., Zerbi, A., & Natoli, G. (2016) · The EMBO Journal · doi:10.15252/embj.201592404 · Cited by 143 · see citing works

Tead2 expression levels control Yap/Taz subcellular distribution, zyxin expression, and epithelial-mesenchymal transition

Diepenbruck, M., Waldmeier, L., Ivánek, R., Berninger, P., Arnold, P., van Nimwegen, E., & Christofori, G. (2014) · Journal of Cell Science · doi:10.1242/jcs.139865 · Cited by 132 · see citing works

Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/β-catenin signaling pathway

Xu, W., Wang, Z., Zhang, W., Qian, K., Li, H., Kong, D., Li, Y., & Tang, Y.-C. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.10.008 · Cited by 130 · see citing works

Cancer theory faces doubts

Ledford, H. K. (2011) · Nature · doi:10.1038/472273a · Cited by 130 · see citing works

Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer

Larriba, M. J., Martín-Villar, E., Garcia, J. M., Pereira, F., Peña, C., de Herreros, A. G., Bonilla, F., & Munoz, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp140 · Cited by 130 · see citing works

ZEB1‐mediated melanoma cell plasticity enhances resistance to MAPK inhibitors

Richard, G., Dalle, S., Monet, M., Plaschka, M., Boespflug, A. M., Pommier, R. M., de la Fouchardière, A., Perier‐Muzet, M., Depaepe, L., Barnault, R., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505971 · Cited by 129 · see citing works

Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

Ni, T., Li, X.-Y., Lu, N., An, T., Liu, Z., Fu, R., Lv, W.-C., Zhang, Y.-W., Xu, X.-J., Rowe, R. G., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3425 · Cited by 129 · see citing works

Pan‐cancer survey of epithelial–mesenchymal transition markers across the Cancer Genome Atlas

Gibbons, D. L., & Creighton, C. J. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24485 · Cited by 128 · see citing works

p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways

Fu, J., Chen, Y., Cao, J., Luo, T., Qian, Y., Yang, W. K., Ren, Y., Su, B., Cao, G., Yang, Y., et al. (2010) · Hepatology · doi:10.1002/hep.24015 · Cited by 127 · see citing works

F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check

Diaz, V. M., & de Herreros, A. G. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.10.003 · Cited by 126 · see citing works

Snail family genes are required for left–right asymmetry determination, but not neural crest formation, in mice

Murray, S. A., & Gridley, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602234103 · Cited by 125 · see citing works

ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM

Zhang, X., Zhang, Z., Zhang, Q., Zhang, Q., Sun, P., Xiang, R., Ren, G., & Yang, S. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0087-3 · Cited by 123 · see citing works

Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2)

Hudson, L. G., Newkirk, K. M., Chandler, H. L., Choi, C., Fossey, S. L., Parent, A. E., & Kusewitt, D. F. (2009) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2009.06.009 · Cited by 121 · see citing works

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1

van den Berghe, V., Stappers, E., Vandesande, B., Dimidschstein, J., Kroes, R., Francis, A., Conidi, A., Lesage, F., Dries, R., Cazzola, S., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.009 · Cited by 120 · see citing works

Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice

Xu, Y., Lee, D.-K., Feng, Z., Xu, Y., Bu, W., Li, Y., Liao, L., & Xu, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618091114 · Cited by 118 · see citing works

Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

Gubelmann, C., Schwalie, P. C., Raghav, S. K., Roeder, E., Challa, T. D., Kiehlmann, E., Waszak, S. M., Corsinotti, A., Udin, G., Holcombe, W., et al. (2014) · eLife · doi:10.7554/elife.03346 · Cited by 115 · see citing works

Aberrant cancer metabolism in epithelial–mesenchymal transition and cancer metastasis: Mechanisms in cancer progression

Huang, R., & Zong, X. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.04.005 · Cited by 115 · see citing works

Regulation of Membrane-Type 4 Matrix Metalloproteinase by SLUG Contributes to Hypoxia-Mediated Metastasis

Huang, C.-H., Yang, W., Chang, S., Tai, S., Tzeng, C., Kao, J., Wu, K.-J., & Yang, M. (2009) · Neoplasia · doi:10.1593/neo.91326 · Cited by 112 · see citing works

Activation of the ATM-Snail pathway promotes breast cancer metastasis

Sun, M., Guo, X., Qian, X., Wang, H., Yang, C., Brinkman, K. L., Gonzalez, M. S., Jope, R. S., Zhou, B. P., Engler, D. A., et al. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs048 · Cited by 111 · see citing works

The ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids

Chiu, L.-Y., Hsin, I., Yang, T.-Y., Sung, W.-W., Chi, J.-Y., Chang, J. T., Ko, J., & Sheu, G. (2016) · Oncogene · doi:10.1038/onc.2016.195 · Cited by 108 · see citing works

ZEB 1‐regulated inflammatory phenotype in breast cancer cells

Katsura, A., Tamura, Y., Hokari, S., Harada, M., Morikawa, M., Sakurai, T., Takahashi, K., Mizutani, A., Nishida, J., Yokoyama, Y., et al. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12098 · Cited by 108 · see citing works

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

Kuo, T.-C., Tan, C., Chang, Y.-W., Hong, C., Lee, W.-J., Chen, M.-W., Jeng, Y., Chiou, J., Yu, P., Chen, P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64044 · Cited by 104 · see citing works

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma

Lim, S., Kim, H., & Jung, G. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.04.006 · Cited by 102 · see citing works

A right-handed signalling pathway drives heart looping in vertebrates

Ocaña, O. H., Coskun, H., Minguillón, C., Murawala, P., Tanaka, E. M., Galcerán, J., Muñoz-Chápuli, R., & Nieto, M. A. (2017) · Nature · doi:10.1038/nature23454 · Cited by 102 · see citing works

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway

Lü, Y., Sun, Y., Zhu, J., Yu, L., Jiang, X., Zhang, J., Dong, X., Ma, B., & Zhang, Q. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0031-6 · Cited by 100 · see citing works

NF-κB–Dependent Plasticity of the Epithelial to Mesenchymal Transition Induced by Von Hippel-Lindau Inactivation in Renal Cell Carcinomas

Pantuck, A. J., An, J., Liu, H., & Rettig, M. B. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2211 · Cited by 95 · see citing works

Epithelial-to-Mesenchymal Transition Antagonizes Response to Targeted Therapies in Lung Cancer by Suppressing BIM

Song, K.-A., Niederst, M. J., Lochmann, T. L., Hata, A. N., Kitai, H., Ham, J., Floros, K. V., Hicks, M. A., Hu, H., Mulvey, H. E., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1577 · Cited by 95 · see citing works

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability

Viñas-Castells, R., Frías, A., Robles-Lanuza, E., Zhang, K., Longmore, G. D., de Herreros, A. G., & Diaz, V. M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt935 · Cited by 93 · see citing works

Hypoxia induces TWIST-activated epithelial–mesenchymal transition and proliferation of pancreatic cancer cells in vitro and in nude mice

Chen, S., Chen, J.-Z., Zhang, J., Chen, H., Yan, M.-L., Huang, L., Tian, Y., Chen, Y., & Wang, Y. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.09.027 · Cited by 93 · see citing works

HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway

Yang, S.-W., Zhang, Z., Hao, Y., Zhao, Y., Qian, F., Shi, Y., Li, P., Liu, C.-Y., & Yu, P.-W. (2017) · Oncotarget · doi:10.18632/oncotarget.14484 · Cited by 89 · see citing works

DNA Binding through Distinct Domains of Zinc‐Finger‐Homeodomain Protein AREB6 has Different Effects on Gene Transcription

Ikeda, K., & Kawakami, K. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.073_1.x · Cited by 88 · see citing works

Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma

Montserrat, N., Mozos, A., Llobet‐Navàs, D., Dolcet, X., Pons, C., de Herreros, A. G., Matías‐Guiu, X., & Prat, J. (2011) · Human Pathology · doi:10.1016/j.humpath.2011.06.021 · Cited by 84 · see citing works

An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factorsPreprint

Chang, A. T., Liu, Y., Ayyanathan, K., Benner, C. W., Jiang, Y., Prokop, J. W., Paz, H., Wang, D., Li, H., Fu, X., et al. (2015) · Genes & Development · doi:10.1101/gad.242842.114 · Cited by 82 · see citing works

Mitochondrial SOD2 regulates epithelial–mesenchymal transition and cell populations defined by differential CD44 expression

Kinugasa, H., Whelan, K. A., Tanaka, K., Natsuizaka, M., Long, A., Guo, A. J., Chang, S., Kagawa, S., Srinivasan, S., Guha, M., et al. (2015) · Oncogene · doi:10.1038/onc.2014.449 · Cited by 80 · see citing works

Discoidin domain receptor 2 ( DDR2 ) promotes breast cancer cell metastasis and the mechanism implicates epithelial–mesenchymal transition programme under hypoxia

Ren, T., Zhang, W., Liu, X., Zhao, H., Zhang, J., Zhang, J., Li, X., Zhang, Y., Bu, X., Shi, M., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4415 · Cited by 78 · see citing works

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

Terry, S., Buart, S., Tan, T. Z., Gros, G., Noman, M. Z., Lorens, J. B., Mami‐Chouaib, F., Thiery, J. P., & Chouaı̈b, S. (2017) · OncoImmunology · doi:10.1080/2162402x.2016.1271858 · Cited by 78 · see citing works

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction

Deshière, A., Duchemin-Pelletier, E., Spreux, E., Ciais, D., Combes, F., Vandenbrouck, Y., Couté, Y., Mikaélian, I., Giusiano, S., Charpin, C., et al. (2012) · Oncogene · doi:10.1038/onc.2012.165 · Cited by 77 · see citing works

Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis

Liu, Y., Lu, X., Huang, L., Wang, W., Jiang, G., Dean, K. C., Clem, B. F., Telang, S., Jenson, A. B., Cuatrecasas, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms6660 · Cited by 73 · see citing works

A genetic cell context-dependent role for ZEB1 in lung cancer

Zhang, T., Guo, L., Creighton, C. J., Lü, Q., Gibbons, D. L., Yi, E. S., Deng, B., Molina, J. R., Sun, Z., Yang, P., et al. (2016) · Nature Communications · doi:10.1038/ncomms12231 · Cited by 73 · see citing works

USP51 promotes deubiquitination and stabilization of ZEB1.

Zhou, Z., Zhang, P., Hu, X., Kim, J., Yao, F., Xiao, Z., Zeng, L., Chang, L., Sun, Y., & Ma, L. (2017) · PubMed Central · Cited by 71 · see citing works

Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells

Park, S., Kim, M.-J., Park, S.-A., Kim, J.-S., Min, K.-N., Kim, D., Lim, W., Nam, J., & Sheen, Y. Y. (2015) · Oncotarget · doi:10.18632/oncotarget.6063 · Cited by 70 · see citing works

Expression of epithelial–mesenchymal transition markers in renal cell carcinoma: impact on prognostic outcomes in patients undergoing radical nephrectomy

Harada, K., Miyake, H., Kusuda, Y., & Fujisawa, M. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11297.x · Cited by 69 · see citing works

Membrane Type 1 Matrix Metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells

Yang, C., Zhu, L., Xu, X., Ning, T., Ye, J., & Liu, L. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-171 · Cited by 69 · see citing works

Complementary expression pattern of Zfhx1 genes Sip1 and δEF1 in the mouse embryo and their genetic interaction revealed by compound mutants

Miyoshi, T., Maruhashi, M., de Putte, T. V., Kondoh, H., Huylebroeck, D., & Higashi, Y. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20799 · Cited by 68 · see citing works

Plasticity of melanoma and EMT-TF reprogramming

Tulchinsky, E. M., Pringle, J. H., Caramel, J., & Ansieau, S. (2013) · Oncotarget · doi:10.18632/oncotarget.1662 · Cited by 67 · see citing works

Enhanced Epithelial-Mesenchymal Transition-like Phenotype in N-Acetylglucosaminyltransferase V Transgenic Mouse Skin Promotes Wound Healing

Terao, M., Ishikawa, A., Nakahara, S., Kimura, A., Kato, A., Moriwaki, K., Kamada, Y., Murota, H., Taniguchi, N., Katayama, I., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220376 · Cited by 67 · see citing works

Cross Talk Mechanism among EMT, ROS, and Histone Acetylation in Phorbol Ester‐Treated Human Breast Cancer MCF‐7 Cells

Kamiya, T., Goto, A., Kurokawa, E., Hara, H., & Adachi, T. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1284372 · Cited by 66 · see citing works

Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

Sikandar, S. S., Kuo, A. H., Tomer Kalisky, C., Cai, S., Zabala, M., Hsieh, R. W., Lobo, N. A., Scheeren, F. A., Sim, S., Qian, D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01666-2 · Cited by 66 · see citing works

Expression patterns of epithelial–mesenchymal transition markers in localized prostate cancer: significance in clinicopathological outcomes following radical prostatectomy

Behnsawy, H. M., Miyake, H., Harada, K., & Fujisawa, M. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11551.x · Cited by 65 · see citing works

Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism

Mathow, D., Chessa, F., Rabionet, M., Kaden, S., Jennemann, R., Sandhoff, R., Gröne, H., & Feuerborn, A. (2015) · EMBO Reports · doi:10.15252/embr.201439333 · Cited by 64 · see citing works

ZEB2 Represses the Epithelial Phenotype and Facilitates Metastasis in Ewing Sarcoma

Wiles, E. T., Bell, R. N., Thomas, D. B., Beckerle, M. C., & Lessnick, S. L. (2013) · Genes & Cancer · doi:10.1177/1947601913506115 · Cited by 64 · see citing works

Involvement of SIP1 in positioning of somite boundaries in the mouse embryo

Maruhashi, M., de Putte, T. V., Huylebroeck, D., Kondoh, H., & Higashi, Y. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20546 · Cited by 62 · see citing works

FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction

Wu, D., Lee, M.-C., Hsu, N.-Y., Wu, T.-C., Wu, J.-Y., Wang, Y.-C., Cheng, Y.-W., Chen, C.-Y., & Lee, H. (2014) · Oncogene · doi:10.1038/onc.2014.184 · Cited by 61 · see citing works

Biological roles and prognostic values of the epithelial–mesenchymal transition‐mediating transcription factors Twist, ZEB1 and Slug in diffuse large B‐cell lymphoma

Lemma, S. A., Karihtala, P., Haapasaari, K., Jantunen, E., Soini, Y., Bloigu, R., Pasanen, A. K., Turpeenniemi-Hujanen, T. M., & Kuittinen, O. M. (2012) · Histopathology · doi:10.1111/his.12000 · Cited by 59 · see citing works

Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail

Cai, W., Ye, Q., & She, Q. (2014) · Oncotarget · doi:10.18632/oncotarget.2109 · Cited by 58 · see citing works

Hyperactivated JNK Is a Therapeutic Target in pVHL-Deficient Renal Cell Carcinoma

An, J., Liu, H., Magyar, C. E., Guo, Y., Veena, M. S., Srivatsan, E. S., Huang, J., & Rettig, M. B. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2362 · Cited by 52 · see citing works

Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells

Kwok, W. K., Ling, M. T., Yuen, H., Wong, Y. C., & Wang, X. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm185 · Cited by 51 · see citing works

Expression of SRSF3 is Correlated with Carcinogenesis and Progression of Oral Squamous Cell Carcinoma

Peiqi, L., Zhaozhong, G., Yaotian, Y., Jun, J., Jihua, G., & Rong, J. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.14871 · Cited by 51 · see citing works

Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis

Chen, Y., & Gridley, T. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1871 · Cited by 50 · see citing works

Knockdown of BAG3 induces epithelial–mesenchymal transition in thyroid cancer cells through ZEB1 activation

Meng, X., Kong, D.-H., Li, N., Zong, Z.-H., Liu, B.-Q., Du, Z., Guan, Y., Cao, L., & Wang, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.32 · Cited by 49 · see citing works

Form follows function: Morphological and immunohistological insights into epithelial–mesenchymal transition characteristics of tumor buds

Enderle-Ammour, K., Bader, M., Ahrens, T. D., Franke, K., Timme, S., Csanádi, Á., Hoeppner, J., Kulemann, B., Maurer, J., Reiss, P., et al. (2017) · Tumor Biology · doi:10.1177/1010428317705501 · Cited by 48 · see citing works

Proapoptotic PUMA targets stem-like breast cancer cells to suppress metastasis

Sun, Q., Lesperance, J., Wettersten, H. I., Luterstein, E., DeRose, Y. S., Welm, A. L., Cheresh, D. A., & Desgrosellier, J. S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93707 · Cited by 48 · see citing works

Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal Identity

Balestrieri, C., Alfarano, G., Milan, M., Tosi, V., Prosperini, E., Nicoli, P., Palamidessi, A., Scita, G., Diaferia, G. R., & Natoli, G. (2018) · Cell · doi:10.1016/j.cell.2018.03.081 · Cited by 45 · see citing works

Insulin-like growth factor-I induces epithelial to mesenchymal transition via GSK-3β and ZEB2 in the BGC-823 gastric cancer cell line

Li, H., Xu, L., Zhao, L., Ma, Y., Zhu, Z., Liu, Y., & Qu, X. (2014) · Oncology Letters · doi:10.3892/ol.2014.2687 · Cited by 43 · see citing works

SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer

Rönsch, K., Jägle, S., Rose, K., Seidl, M., Baumgartner, F., Freihen, V., Yousaf, A., Metzger, E., Laßmann, S., Schüle, R., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.08.016 · Cited by 43 · see citing works

Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition

Diepenbruck, M., Waldmeier, L., Ivanek, R., Berninger, P., Arnold, P., van Nimwegen, E., & Christofori, G. (2014) · edoc (University of Basel) · doi:10.5451/unibas-ep38755 · Cited by 42 · see citing works

Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance

Bildsoe, H., Fan, X., Wilkie, E. E., Ashoti, A., Jones, V. J., Power, M., Qin, J., Wang, J., Tam, P., & Loebel, D. A. F. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.08.016 · Cited by 41 · see citing works

L1CAM expression in endometrial carcinomas is regulated by usage of two different promoter regions

Pfeifer, M., Schirmer, U. B., Geismann, C., Schäfer, H., Sebens, S., & Altevogt, P. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-64 · Cited by 40 · see citing works

Reactive oxygen species mediate oxaliplatin-induced epithelial-mesenchymal transition and invasive potential in colon cancer

Jiao, L., Li, D., Yang, C.-L., Peng, R.-Q., Guo, Y.-Q., Zhang, X.-S., & Zhu, X. (2016) · Tumor Biology · doi:10.1007/s13277-015-4736-9 · Cited by 39 · see citing works

Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

Wang, J., Ye, Q., Cao, Y., Guo, Y., Huang, X., Mi, W., Liu, S., Wang, C., Yang, H., Zhou, B. P., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02243-3 · Cited by 38 · see citing works

HIFs enhance the migratory and neoplastic capacities of hepatocellular carcinoma cells by promoting EMT

Liu, Y., Liu, Y., Yan, X., Xu, Y., Luo, F., Ye, J., Yan, H., Yang, X., Huang, X., Zhang, J., et al. (2014) · Tumor Biology · doi:10.1007/s13277-014-2056-0 · Cited by 37 · see citing works

Generation of a Snail1 (<i>Snai1</i>) conditional null allele

Murray, S. A., Carver, E. A., & Gridley, T. (2006) · genesis · doi:10.1002/gene.20178 · Cited by 35 · see citing works

Generation and characterization of mice for conditional inactivation of Zeb1

Brabletz, S., Losada, M. L., Schmalhofer, O., Mitschke, J., Krebs, A. M., Brabletz, T., & Stemmler, M. P. (2017) · genesis · doi:10.1002/dvg.23024 · Cited by 29 · see citing works

Transition loses its invasive edge

Maheswaran, S., & Haber, D. A. (2015) · Nature · doi:10.1038/nature16313 · Cited by 27 · see citing works

Androgens induce a distinct response of epithelial-mesenchymal transition factors in human prostate cancer cells

Colditz, J., Rupf, B., Maiwald, C., & Baniahmad, A. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2794-y · Cited by 27 · see citing works

Short stretches of rare codons regulate translation of the transcription factor ZEB2 in cancer cells

Makhtar, W. R. W., Browne, G. J., Karountzos, A. S., Stevens, C., Alghamdi, Y. S., Bottrill, A. R., Mistry, S. C., Smith, E. M., Bushel, M., Pringle, J. H., et al. (2017) · Oncogene · doi:10.1038/onc.2017.273 · Cited by 25 · see citing works

SLUG expression is an indicator of tumour recurrence in high‐grade endometrial carcinomas

Kihara, A., Wakana, K., Kubota, T., & Kitagawa, M. (2016) · Histopathology · doi:10.1111/his.12971 · Cited by 21 · see citing works

Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7

Vesuna, F., Winnard, P., Raman, V., & Glackin, C. A. (2006) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2006.01.014 · Cited by 20 · see citing works

ATM-mediated Snail Serine 100 phosphorylation regulates cellular radiosensitivity

Boohaker, R. J., Cui, X., Stackhouse, M. A., & Xu, B. (2013) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.06.017 · Cited by 17 · see citing works

Bisphenol A regulates Snail‐mediated epithelial‐mesenchymal transition in hemangioma cells

Zhai, D., He, J., Li, X., Gong, L., & Ouyang, Y. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3206 · Cited by 17 · see citing works

Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors

Balçık-Erçin, P., Çetįn, M., Camcı, İ. Y., Odabas, G., Tokay, N., Sayan, E., & Yağcı, T. (2018) · Cellular Oncology · doi:10.1007/s13402-018-0375-7 · Cited by 15 · see citing works

Erratum: FHIT loss confers cisplatin resistance in lung cancer via the AKT/NF-κB/Slug-mediated PUMA reduction

Wu, D.-W., Lee, M., Hsu, N.-Y., Wu, T. ‐., Wu, J.-Y., Wang, Y., Cheng, Y.-W., Chen, C.-Y., & Lee, H. (2017) · Oncogene · doi:10.1038/onc.2017.249 · Cited by 13 · see citing works

Complementary expression pattern of Zfhx1 genes Sip1 and dEF1 in the mouse embryo and their genetic interaction revealed by compound mutants.

三好, 智. (2006) · Cited by 3 · see citing works

Oxidative Stress in Cancer

Hayes, J. D., Dinkova-Kostova, A. T., & Tew, K. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.06.001 · Cited by 2,654 · see citing works

Guidelines and definitions for research on epithelial-mesenchymal transition

Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226 · see citing works

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Huang, Y., Hong, W., & Wei, X. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01347-8 · Cited by 1,065 · see citing works

Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis

Lu, W., & Kang, Y. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.010 · Cited by 1,022 · see citing works

EMT, MET, Plasticity, and Tumor Metastasis

Bakir, B. S., Chiarella, A. M., Pitarresi, J. R., & Rustgi, A. K. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.07.003 · Cited by 1,030 · see citing works

Epithelial-Mesenchymal Transition in Cancer: A Historical Overview

Ribatti, D., Tamma, R., & Annese, T. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100773 · Cited by 1,012 · see citing works

Dynamic EMT: a multi‐tool for tumor progression

Brabletz, S., Schuhwerk, H., Brabletz, T., & Stemmler, M. P. (2021) · The EMBO Journal · doi:10.15252/embj.2021108647 · Cited by 770 · see citing works

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 772 · see citing works

Context-dependent EMT programs in cancer metastasis

Aiello, N. M., & Kang, Y. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181827 · Cited by 586 · see citing works

Linking EMT programmes to normal and neoplastic epithelial stem cells

Lambert, A. W., & Weinberg, R. A. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00332-6 · Cited by 530 · see citing works

Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progression

Lüönd, F., Tiede, S., & Christofori, G. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01328-7 · Cited by 442 · see citing works

Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states

Simeonov, K. P., Byrns, C. N., Clark, M. L., Norgard, R. J., Martin, B., Stanger, B. Z., Shendure, J., McKenna, A., & Lengner, C. J. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.05.005 · Cited by 388 · see citing works

Cancer cell plasticity during tumor progression, metastasis and response to therapy

Pérez-González, A., Bévant, K., & Blanpain, C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00595-y · Cited by 353 · see citing works

EMT and Cancer: More Than Meets the Eye

Derynck, R., & Weinberg, R. A. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.04.026 · Cited by 313 · see citing works

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

Tam, S. Y., Wu, V., & Law, H. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00486 · Cited by 304 · see citing works

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance

Bhat, G. R., Sethi, I., Sadida, H. Q., Rah, B., Mir, R., Algehainy, N. A., Albalawi, I. A., Masoodi, T., Subbaraj, G. K., Jamal, F., et al. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10172-z · Cited by 313 · see citing works

Emerging role of tumor cell plasticity in modifying therapeutic response

Qin, S., Jiang, J., Lü, Y., Nice, E. C., Huang, C., Zhang, J., & He, W. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00313-5 · Cited by 274 · see citing works

An early cell shape transition drives evolutionary expansion of the human forebrain

Benito-Kwiecinski, S. K., Giandomenico, S. L., Sutcliffe, M. A., Riis, E. S., Freire-Pritchett, P., Kelava, I., Wunderlich, S., Martin, U., Wray, G. A., McDole, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.02.050 · Cited by 275 · see citing works

GM-CSF: A Double-Edged Sword in Cancer Immunotherapy

Kumar, A., Khani, A. T., Ortiz, A. S., & Swaminathan, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.901277 · Cited by 277 · see citing works

A cellular hierarchy in melanoma uncouples growth and metastasis

Karras, P., Bordeu, I., Poźniak, J., Nowosad, A., Pazzi, C., Raemdonck, N. V., Landeloos, E., Herck, Y. V., Pedri, D., Bervoets, G., et al. (2022) · Nature · doi:10.1038/s41586-022-05242-7 · Cited by 251 · see citing works

The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance

Loret, N., Denys, H. G., Tummers, P., & Berx, G. (2019) · Cancers · doi:10.3390/cancers11060838 · Cited by 241 · see citing works

Epigenetic regulation of epithelial-mesenchymal transition: focusing on hypoxia and TGF-β signaling

Lin, Y., & Wu, K. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00632-3 · Cited by 230 · see citing works

Zinc-Dependent Regulation of ZEB1 and YAP1 Coactivation Promotes Epithelial-Mesenchymal Transition Plasticity and Metastasis in Pancreatic Cancer

Liu, M., Zhang, Y., Yang, J., Zhan, H., Zhou, Z., Jiang, Y., Shi, X., Fan, X., Zhang, J., Luo, W., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.077 · Cited by 211 · see citing works

Emerging Mechanisms by which EMT Programs Control Stemness

Wilson, M. M., Weinberg, R. A., Lees, J. A., & Guen, V. J. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.03.011 · Cited by 201 · see citing works

Molecular Bases of Drug Resistance in Hepatocellular Carcinoma

Marı́n, J. J. G., Macı́as, R. I. R., Monte, M. J., Romero, M. R., Asensio, M., Sánchez-Martín, A., Cives-Losada, C., Temprano, Á. G., Espinosa-Escudero, R. A., Reviejo, M., et al. (2020) · Cancers · doi:10.3390/cancers12061663 · Cited by 202 · see citing works

Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension

Gorelova, A., Berman, M., & Ghouleh, I. A. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8169 · Cited by 178 · see citing works

Epithelial-Mesenchymal Transition (EMT) as a Therapeutic Target

Jonckheere, S., Adams, J., Groote, D. D., Campbell, K., Berx, G., & Goossens, S. (2021) · Cells Tissues Organs · doi:10.1159/000512218 · Cited by 173 · see citing works

Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition

Schwab, A., Rao, Z., Zhang, J., Gollowitzer, A., Siebenkäs, K., Bindel, N., D’Avanzo, E., van Roey, R., Hajjaj, Y., Özel, E., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01464-1 · Cited by 172 · see citing works

EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?

Akhmetkaliyev, A., Alibrahim, N., Shafiee, D., & Tulchinsky, E. M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01793-z · Cited by 170 · see citing works

Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

Tanaka, K., Yu, H. A., Yang, S., Han, S., Selçuklu, S. D., Kim, K., Ramani, S., Ganesan, Y. T., Moyer, A. F., Sinha, S., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.07.006 · Cited by 165 · see citing works

Metastasis and MAPK Pathways

Kciuk, M., Gielecińska, A., Budzinska, A., Mojzych, M., & Kontek, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073847 · Cited by 170 · see citing works

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Huang, Z., Zhang, Z., Zhou, C., Liu, L., & Huang, C. (2022) · MedComm · doi:10.1002/mco2.144 · Cited by 170 · see citing works

Genome‐wide cooperation of EMT transcription factor ZEB1 with YAP and AP‐1 in breast cancer

Feldker, N., Ferrazzi, F., Schuhwerk, H., Widholz, S. A., Guenther, K., Frisch, I., Jakob, K., Kleemann, J., Riegel, D., Bönisch, U., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103209 · Cited by 164 · see citing works

Heterogeneity and plasticity of epithelial–mesenchymal transition (EMT) in cancer metastasis: Focusing on partial EMT and regulatory mechanisms

Li, D., Xia, L., Huang, P., Wang, Z., Guo, Q., Huang, C., Leng, W., & Qin, S. (2023) · Cell Proliferation · doi:10.1111/cpr.13423 · Cited by 157 · see citing works

Tumor Plasticity and Resistance to Immunotherapy

Horn, L. A., Fousek, K., & Palena, C. (2020) · Trends in cancer · doi:10.1016/j.trecan.2020.02.001 · Cited by 142 · see citing works

Role of Epithelial to Mesenchymal Transition in Colorectal Cancer

Lu, J., Kornmann, M., & Traub, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914815 · Cited by 148 · see citing works

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

Haerinck, J., Goossens, S., & Berx, G. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-023-00601-0 · Cited by 138 · see citing works

Endocytosis in the context-dependent regulation of individual and collective cell properties

Sigismund, S., Lanzetti, L., Scita, G., & Di Fiore, P. P. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00375-5 · Cited by 132 · see citing works

Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion

Wang, S., Matsumoto, K., Lish, S. R., Cartagena‐Rivera, A. X., & Yamada, K. M. (2021) · Cell · doi:10.1016/j.cell.2021.05.015 · Cited by 124 · see citing works

RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

Yu, D., Pan, M., Li, Y., Lu, T., Wang, Z., Liu, C., & Hu, G. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02212-1 · Cited by 123 · see citing works

Vascular smooth muscle-derived Trpv1+ progenitors are a source of cold-induced thermogenic adipocytes

Shamsi, F., Piper, M. E., Ho, L., Huang, T. L., Gupta, A., Streets, A., Lynes, M. D., & Tseng, Y. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00373-z · Cited by 121 · see citing works

EMT-Associated Heterogeneity in Circulating Tumor Cells: Sticky Friends on the Road to Metastasis

Genna, A., Vanwynsberghe, A. M., Villard, A. V., Pottier, C., Ancel, J., Polette, M., & Gilles, C. (2020) · Cancers · doi:10.3390/cancers12061632 · Cited by 116 · see citing works

Single-Cell Analyses Reveal Mechanisms of Cancer Stem Cell Maintenance and Epithelial–Mesenchymal Transition in Recurrent Bladder Cancer

Wang, H., Mei, Y., Luo, C., Huang, Q., Wang, Z., Lu, G.-M., Qin, L., Sun, Z., Huang, C.-W., Yang, Z.-W., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-4796 · Cited by 116 · see citing works

Molecular mechanisms underpinning sarcomas and implications for current and future therapy

Damerell, V., Pepper, M. S., & Prince, S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00647-8 · Cited by 114 · see citing works

Molecular regulation of Snai2 in development and disease

Zhou, W., Gross, K. M., & Kuperwasser, C. (2019) · Journal of Cell Science · doi:10.1242/jcs.235127 · Cited by 109 · see citing works

PRMT5 activates AKT via methylation to promote tumor metastasis

Huang, L., Zhang, X.-O., Rozen, E. J., Sun, X., Sallis, B., Verdejo‐Torres, O., Wigglesworth, K., Moon, D., Huang, T., Cavaretta, J. P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31645-1 · Cited by 109 · see citing works

Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease

Hall, I. F., Kishta, F., Xu, Y., Baker, A. H., & Kovacic, J. C. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae021 · Cited by 108 · see citing works

A PLCB1–PI3K–AKT Signaling Axis Activates EMT to Promote Cholangiocarcinoma Progression

Liang, S., Guo, H., Ma, K., Li, X., Wu, D., Wang, Y., Wang, W., Zhang, S., Cui, Y., Liu, Y., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1538 · Cited by 105 · see citing works

Dual role of E-cadherin in cancer cells

Rubtsova, S. N., Zhitnyak, I. Y., & Gloushankova, N. A. (2021) · Tissue Barriers · doi:10.1080/21688370.2021.2005420 · Cited by 101 · see citing works

EMT and Stemness—Key Players in Pancreatic Cancer Stem Cells

Rodríguez-Aznar, E., Wiesmüller, L., Sainz, B., & Hermann, P. (2019) · Cancers · doi:10.3390/cancers11081136 · Cited by 93 · see citing works

Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer

Tagliazucchi, G. M., Wiecek, A. J., Withnell, E., & Secrier, M. (2023) · Nature Communications · doi:10.1038/s41467-023-36439-7 · Cited by 95 · see citing works

New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression

Bhatia, S., Wang, P., Toh, A. K. L., & Thompson, E. W. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00071 · Cited by 94 · see citing works

A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer

Francescangeli, F., Contavalli, P., Angelis, M. L. D., Careccia, S., Signore, M., Haas, T. L., Salaris, F., Baiocchi, M., Boe, A., Giuliani, A., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1505-4 · Cited by 89 · see citing works

The transcription factor BACH1 at the crossroads of cancer biology: From epithelial–mesenchymal transition to ferroptosis

Igarashi, K., Nishizawa, H., Saiki, Y., & Matsumoto, M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101032 · Cited by 86 · see citing works

Epithelial-to-Mesenchymal Transition in Fibrosis: Concepts and Targeting Strategies

Lovisa, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.737570 · Cited by 84 · see citing works

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements

Anderson, A. G., Rogers, B. B., Loupe, J. M., Rodriguez-Nunez, I., Roberts, S. C., White, L. M., Brazell, J. N., Bunney, W. E., Bunney, B. G., Watson, S. J., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100263 · Cited by 82 · see citing works

Glioblastoma Microenvironment and Cellular Interactions

Crivii, C. B., Boşca, A. B., Melincovici, C. S., Constantin, A.-M., Mărginean, M. V., Dronca, E., Suflețel, R. T., Gonciar, D., Bungărdean, R. M., & Şovrea, A. S. (2022) · Cancers · doi:10.3390/cancers14041092 · Cited by 82 · see citing works

Targeting cancer stem cells in squamous cell carcinoma

Chen, D., & Wang, C. (2019) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbz016 · Cited by 81 · see citing works

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer

Kar, R., Jha, N. K., Jha, S. K., Sharma, A., Dholpuria, S., Asthana, N., Chaurasiya, K., Singh, V. K., Burgee, S., & Nand, P. (2019) · Genes · doi:10.3390/genes10120961 · Cited by 81 · see citing works

GREM1 is required to maintain cellular heterogeneity in pancreatic cancer

Lan, L., Evan, T., Li, H., Hussain, A., Ruiz, E. J., Thin, M. Z., Ferreira, R. M. M., Hari, P. S., Riising, E. M., Zen, Y., et al. (2022) · Nature · doi:10.1038/s41586-022-04888-7 · Cited by 81 · see citing works

The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype

Khatib, A., Solaimuthu, B., Yosef, M. B., Rmaileh, A. A., Tanna, M., Oren, G., Frisch, M. S., Axelrod, J. H., Lichtenstein, M., & Shaul, Y. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010275117 · Cited by 77 · see citing works

The Post-Translational Regulation of Epithelial–Mesenchymal Transition-Inducing Transcription Factors in Cancer Metastasis

Kang, E., Seo, J., Yoon, H., & Cho, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073591 · Cited by 78 · see citing works

Physiological functions of junctional adhesion molecules (JAMs) in tight junctions

Hartmann, C., Schwietzer, Y. A., Otani, T., Furuse, M., & Ebnet, K. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183299 · Cited by 74 · see citing works

Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis

Lin, P. P. (2020) · Cells · doi:10.3390/cells9061539 · Cited by 76 · see citing works

Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response

Jia, D., Li, X., Bocci, F., Tripathi, S., Deng, Y., Jolly, M. K., Onuchic, J. N., & Levine, H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050725 · Cited by 72 · see citing works

FAM83A signaling induces epithelial-mesenchymal transition by the PI3K/AKT/Snail pathway in NSCLC

Zhou, F., Geng, J., Xu, S., Meng, Q., Chen, K., Liu, F., Yang, F., Pan, B., & Yu, Y. (2019) · Aging · doi:10.18632/aging.102163 · Cited by 75 · see citing works

Roles of the Phosphorylation of Transcriptional Factors in Epithelial-Mesenchymal Transition

Xu, R., Won, J.-Y., Kim, C.-H., Kim, D., & Yim, H. (2019) · Journal of Oncology · doi:10.1155/2019/5810465 · Cited by 73 · see citing works

NCAPG2 overexpression promotes hepatocellular carcinoma proliferation and metastasis through activating the STAT3 and NF-κB/miR-188-3p pathways

Meng, F., Zhang, S., Song, R., Liu, Y., Wang, J., Liang, Y., Wang, J., Han, J., Song, X., Lu, Z., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.05.053 · Cited by 73 · see citing works

Snail1: A Transcriptional Factor Controlled at Multiple Levels

Baulida, J., Diaz, V. M., & de Herreros, A. G. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060757 · Cited by 74 · see citing works

EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis

Peluffo, G., Subedee, A., Harper, N. W., Kingston, N. L., Jovanović, B., Flores, F. N., Stevens, L. E., de Beça, F. F., Trinh, A. C., Chilamakuri, C. S. R., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3264 · Cited by 69 · see citing works

Determinants of renal cell carcinoma invasion and metastatic competence

Kim, K., Zhou, Q.-B., Christie, A., Stevens, C., Ma, Y., Onabolu, O., Chintalapati, S., McKenzie, T., Tcheuyap, V., Woolford, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25918-4 · Cited by 69 · see citing works

Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis

Shi, Y., Tao, M., Chen, H., Ma, X., Wang, Y., Hu, Y., Zhou, X. C., Li, J., Cui, B., Qiu, A., et al. (2022) · Kidney International · doi:10.1016/j.kint.2022.11.027 · Cited by 67 · see citing works

Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis

Neufert, C. F., Heichler, C., Brabletz, T., Koop, K., Boonsanay, V., Greten, F. R., & Neurath, M. F. (2020) · Nature Protocols · doi:10.1038/s41596-020-00412-1 · Cited by 66 · see citing works

βIII-tubulin overexpression in cancer: Causes, consequences, and potential therapies

Kanakkanthara, A., & Miller, J. H. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188607 · Cited by 66 · see citing works

Epithelial-mesenchymal transition in colorectal cancer metastasis and progression: molecular mechanisms and therapeutic strategies

Nie, F., Sun, X., Sun, J., Zhang, J., & Wang, Y. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02593-8 · Cited by 66 · see citing works

Pathogenesis of periodontitis – A potential role for epithelial-mesenchymal transition

Saliem, S. S., Bede, S. Y. H., Cooper, P. R., Abdulkareem, A. A., Milward, M. R., & Abdullah, B. H. (2022) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2022.09.001 · Cited by 74 · see citing works

Epithelial to Mesenchymal Transition: Key Regulator of Pancreatic Ductal Adenocarcinoma Progression and Chemoresistance

Palamaris, K., Felekouras, E. S., & Sakellariou, S. (2021) · Cancers · doi:10.3390/cancers13215532 · Cited by 65 · see citing works

The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma

Evan, T., Wang, V. M.-Y., & Behrens, A. (2022) · Oncogene · doi:10.1038/s41388-022-02448-x · Cited by 62 · see citing works

GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail

Chen, L., Cai, Q., Yang, R., Wang, H., Ling, H., Li, T., Liu, N., Wang, Z., Sun, J., Tao, T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219585120 · Cited by 64 · see citing works

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Slowicka, K., Πέττα, Ι., Blancke, G., Hoste, E., Dumas, E., Sze, M., Vikkula, H., Radaelli, E., Haigh, J. J., Jonckheere, S., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0070-2 · Cited by 63 · see citing works

Epithelial–Mesenchymal Transition Signaling and Prostate Cancer Stem Cells: Emerging Biomarkers and Opportunities for Precision Therapeutics

Chaves, L. P., Melo, C. M., Saggioro, F. P., dos Reis, R. B., & Squire, J. A. (2021) · Genes · doi:10.3390/genes12121900 · Cited by 66 · see citing works

Transcriptional census of epithelial-mesenchymal plasticity in cancer

Cook, D. P., & Vanderhyden, B. C. (2022) · Science Advances · doi:10.1126/sciadv.abi7640 · Cited by 62 · see citing works

Contribution of Epithelial Plasticity to Therapy Resistance

Santamarı́a, P. G., Moreno‐Bueno, G., & Cano, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050676 · Cited by 62 · see citing works

Epithelial–mesenchymal plasticity in kidney fibrosis

Hadpech, S., & Thongboonkerd, V. (2023) · genesis · doi:10.1002/dvg.23529 · Cited by 62 · see citing works

EMT and cancer: what clinicians should know

Thompson, E. W., Redfern, A. D., Brabletz, S., Berx, G., Agarwal, V., Ganesh, K., Huang, R. Y., Ishay-Ronen, D., Savagner, P., Sheng, G., et al. (2025) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-025-01058-2 · Cited by 70 · see citing works

Slug and E-Cadherin: Stealth Accomplices?

Sterneck, E., Poria, D. K., & Balamurugan, K. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00138 · Cited by 61 · see citing works

A Computational Systems Biology Approach Identifies SLUG as a Mediator of Partial Epithelial-Mesenchymal Transition (EMT)

Subbalakshmi, A. R., Sahoo, S., Biswas, K., & Jolly, M. K. (2021) · Cells Tissues Organs · doi:10.1159/000512520 · Cited by 61 · see citing works

Genomic control of metastasis

Patel, S. A., Rodrigues, P., Wesolowski, L., & Vanharanta, S. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01127-6 · Cited by 58 · see citing works

Specification and epigenomic resetting of the pig germline exhibit conservation with the human lineage

Zhu, Q., Sang, F., Withey, S., Tang, W. W. C., Dietmann, S., Klisch, D., Ramos‐Ibeas, P., Zhang, H., Requena, C. E., Hájková, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108735 · Cited by 60 · see citing works

Epithelial–mesenchymal plasticity: emerging parallels between tissue morphogenesis and cancer metastasis

Plygawko, A. T., Kan, S., & Campbell, K. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0087 · Cited by 59 · see citing works

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Carmichael, C., Wang, J., Nguyen, T. M., Kolawole, O., Benyoucef, A., Mazière, C. D., Milne, A. R., Samuel, S., Gillinder, K. R., Hediyeh-zadeh, S., et al. (2020) · Blood · doi:10.1182/blood.2019002548 · Cited by 56 · see citing works

The role of proteases in epithelial-to-mesenchymal cell transitions in cancer

Mitschke, J., Burk, U., & Reinheckel, T. (2019) · Cancer Metastasis Review · doi:10.1007/s10555-019-09808-2 · Cited by 38 · see citing works

Phenotypic Heterogeneity of Triple-Negative Breast Cancer Mediated by Epithelial–Mesenchymal Plasticity

Kvokačková, B., Remšík, J., Jolly, M. K., & Souček, K. (2021) · Cancers · doi:10.3390/cancers13092188 · Cited by 57 · see citing works

Integrated Single-Cell Transcriptomics and Chromatin Accessibility Analysis Reveals Regulators of Mammary Epithelial Cell Identity

Pervolarakis, N., Nguyen, Q., Williams, J., Gong, Y., Gutierrez, G., Sun, P., Jiandani, D., Zheng, G. X. Y., Nemec, C. M., Dai, X., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108273 · Cited by 57 · see citing works

Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review)

Zhang, G., Hou, S., Li, S., Wang, Y., & Cui, W. (2024) · International Journal of Oncology · doi:10.3892/ijo.2024.5636 · Cited by 56 · see citing works

Antitumor functions and mechanisms of nitidine chloride in human cancers

Cui, Y., Wu, L., Cao, R., Xu, H., Xia, J., Wang, Z. P., & Ma, J. (2019) · Journal of Cancer · doi:10.7150/jca.37890 · Cited by 57 · see citing works

ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway

Guo, Q., Xu, J., Huang, Z., Yao, Q., Chen, F.-S., Liu, H., Zhang, Z., & Lin, J. (2020) · Clinical & Translational Oncology · doi:10.1007/s12094-020-02422-7 · Cited by 53 · see citing works

Hypoxia-induced TGF-β–RBFOX2–ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer

Ahuja, N., Ashok, C., Natua, S., Pant, D., Cherian, A., Pandkar, M. R., Yadav, P., Vishnu Narayanan, S. S., Mishra, J., Samaiya, A., et al. (2020) · NAR Cancer · doi:10.1093/narcan/zcaa021 · Cited by 53 · see citing works

Comprehensive analysis of EMT-related genes and lncRNAs in the prognosis, immunity, and drug treatment of colorectal cancer

Yang, Y., Feng, M., Bai, L., Liao, W., Zhou, K., Zhang, M., Wu, Q., Wen, F., Lei, W., Zhang, P., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03065-0 · Cited by 52 · see citing works

AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew

Auyez, A., Sayan, E., Kriajevska, M. V., & Tulchinsky, E. M. (2021) · Cancers · doi:10.3390/cancers13194864 · Cited by 50 · see citing works

EMT transcription factors in cancer development re-evaluated: Beyond EMT and MET

Goossens, S., Vandamme, N., Vlierberghe, P. V., & Berx, G. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.06.006 · Cited by 292 · see citing works

Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors

Imodoye, S. O., Adedokun, K. A., Muhammed, A. O., Bello, I. O., Muhibi, M. A., Oduola, T., & Oyenike, M. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.762817 · Cited by 49 · see citing works

Epithelial–mesenchymal transition and its transcription factors

Debnath, P., Huirem, R. S., Dutta, P., & Palchaudhuri, S. (2021) · Bioscience Reports · doi:10.1042/bsr20211754 · Cited by 293 · see citing works

Epithelial mesenchymal transition Transcription Factor (TF): The structure, function and microRNA feedback loop

Alidadiani, N., Ghaderi, S., Dilaver, N., Bakhshamin, S., & Bayat, M. (2018) · Gene · doi:10.1016/j.gene.2018.06.049 · Cited by 36 · see citing works

Role of E2Fs and mitotic regulators controlled by E2Fs in the epithelial to mesenchymal transition

Jusino, S., & Saavedra, H. I. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219881360 · Cited by 21 · see citing works