Systematic review on first trimester three‐dimensional placental volumetry predicting small for gestational age infants
Abstract
Objective: A systematic review and pooled analysis was carried out to estimate (i) the reference values and (ii) the potential value of measuring the first‐trimester 3D‐placental volume (PV) for predicting small for gestational age (SGA) infants. Method: A comprehensive literature search for relevant studies was conducted using the PubMed and Web of Knowledge databases. A simulation model was generated to calculate the detection rate (DR) of the PV for SGA infants. A random variable was generated having the same number of cases, and the same means and standard deviation as those reported in the articles considered for the analysis. Results: For the evaluation of the normal values of PV, 12 studies met the inclusion criteria. Four also produced an equation for PV estimation at 11 to 14 weeks. The weighted mean PV [±standard error of mean (SEM)] of 7519 cases was 59.40 ± 1.533 mL. For the estimation of PV performance in predicting SGA, five studies were included. The DR of the PV was 24.7% (19.3–30.1) at a 10% false–positive rate. Conclusion: The mean PV estimation of the studies analyzed was burdened by a high degree of heterogeneity. Instead, discordant results were reported for the possible prediction of SGA infants using PV. Surprisingly, just two articles reported the DR for SGA infants and also had proper statistical power. The discriminatory ability of using PV alone for predicting SGA appears to be modest, but could successfully be integrated into a multivariable screening method for SGA infants. © 2015 John Wiley & Sons, Ltd.
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Placental volume is often smaller in hypertensive pregnancies and cases with growth restriction.
“It is well-documented that placental volume is often smaller in hypertensive pregnancies and cases with growth restriction23,24.”
From Multi-centre deep learning for placenta segmentation in obstetric ultrasound with multi-observer and cross-country generalization (2023) · cites this paper as [23]
A recent systematic review concluded that PlVol could be successfully integrated into a future multivariable screening method for SGA.
“As PlVol has also been demonstrated to be independent of other biomarkers for SGA, such as pregnancy-associated plasma protein A (PAPP-A) (8, 11) and nuchal translucency (11), a recent systematic review concluded that it could be successfully integrated into a future multivariable screening method for SGA (12) analogous to the 'combined test' currently used to screen for fetal aneuploidy.”
From Fully automated, real-time 3D ultrasound segmentation to estimate first trimester placental volume using deep learning (2018) · cites this paper as [12]
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- Authors
- Farina, A.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Farina, Antonio
- ORCID
- Farina, Antonio
- Venue
- Prenatal Diagnosis
- Publisher
- Wiley
- Published
- 2016-01-19
- Volume
- 36
- Issue
- 2
- Pages
- 135-141
- ISSN
- 0197-3851 (ISSN-L)
- 1097-0223
- OpenAlex
- W2188503772
- Cited by
- 28
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 3
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prenatal Diagnosis (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- placental volume, small for gestational age, first trimester, reference values, fetal growth restriction prediction, detection rate, prenatal screening
- MeSH terms
- Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Small for Gestational Age, Organ Size, Placenta, Pregnancy, Pregnancy Trimester, First, Ultrasonography, Prenatal, Imaging, Three-Dimensional
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